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Twenty of them showed signs of lethargy, anorexia or pyrexia, 13 had been vomiting or had diarrhoea, 12 had shown signs of pain in the joints or bones and been lame, five had had reactions at the site of an injection, five had generalised lymphadenopathy, three had urinary tract infections and two had recurrent or severe pyoderma. They all had a lower concentration of one or more classes of serum immunoglobulin (IgG, IgM and IgA) than the standard control ranges, and their mean concentration of IgG was significantly lower (P&amp;#60;0.005) than the mean concentration of IgG in 15 clinically normal weimaraners. Of 10 cases for which a complete vaccination history was available, nine had developed clinical signs within five days of being vaccinated. Follow\u2010up data were available from 21 of the 25 dogs for a median period of 24.5\u00a0months. One dog died during a symptomatic episode, three were euthanased, six were alive at follow\u2010up but had continued to show clinical signs and 11 had made a full recovery.<\/jats:p>","DOI":"10.1136\/vr.153.18.553","type":"journal-article","created":{"date-parts":[[2010,10,8]],"date-time":"2010-10-08T13:44:05Z","timestamp":1286545445000},"page":"553-558","source":"Crossref","is-referenced-by-count":27,"title":["Retrospective study of 25 young weimaraners with low serum immunoglobulin concentrations and inflammatory disease"],"prefix":"10.1002","volume":"153","author":[{"given":"R. D.","family":"Foale","sequence":"first","affiliation":[{"name":"The Queen's Veterinary School Hospital University of Cambridge Madingley Road Cambridge CB3 OES"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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