{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T04:39:25Z","timestamp":1794285565486,"version":"4.9.0"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2003,8,9]],"date-time":"2003-08-09T00:00:00Z","timestamp":1060387200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:p>\n                    Twenty\u2010four specific pathogen\u2010free beagles were randomly allocated into four groups (three vaccinated groups and one control group) and inoculated at nine and 12 weeks of age with one of three commercial inactivated\n                    <jats:italic>Leptospira<\/jats:italic>\n                    vaccines: A (Vanguard 7; Pfizer Sant\u00e9 Animale), B (Dohyvac 7L; Fort Dodge), and C (Nobivac DHPPi + Lepto; Intervet Intemational); the control group received Nobivac DHPPi (Intervet International). Seven weeks after the second vaccination all the dogs were challenged with\n                    <jats:italic>Leptospira interrogans<\/jats:italic>\n                    serogroup canicola. All the vaccinated dogs developed a mild serological response (microscopic agglutination titres) after the booster vaccination. A significant serological response after the challenge was observed, particularly in the controls. The challenge induced fever and clinical disorders in the control group, whereas in the vaccinated groups the clinical signs were mild. Blood cultures became positive in all control dogs, and in one of six dogs vaccinated with vaccine A and two of four dogs vaccinated with vaccine B; none of the six dogs vaccinated with vaccine C was leptospiraemic at any stage of the experiment. Urine cultures were positive in all the control dogs two weeks after the challenge. One of six dogs vaccinated with vaccine A and two of four dogs vaccinated with vaccine B shed bacteria in their urine after the challenge, but none of the dogs vaccinated with vaccine C shed bacteria in their urine at any time during the experiment.\n                  <\/jats:p>","DOI":"10.1136\/vr.153.6.165","type":"journal-article","created":{"date-parts":[[2010,10,8]],"date-time":"2010-10-08T13:44:05Z","timestamp":1286545445000},"page":"165-169","source":"Crossref","is-referenced-by-count":47,"title":["Comparison of the efficacy of three commercial bacterins in preventing canine leptospirosis"],"prefix":"10.1002","volume":"153","author":[{"given":"G.","family":"Andr\u00e9\u2010Fontaine","sequence":"first","affiliation":[{"name":"Ecole Nationale V\u00e9t\u00e9rinaire Bact\u00e9riologie M\u00e9dicale et Mol\u00e9culaire des Leptospires Route de Gachet, BP 40706 44307 Nantes Cedex 3 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Branger","sequence":"additional","affiliation":[{"name":"Ecole Nationale V\u00e9t\u00e9rinaire Bact\u00e9riologie M\u00e9dicale et Mol\u00e9culaire des Leptospires Route de Gachet, BP 40706 44307 Nantes Cedex 3 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. W.","family":"Gray","sequence":"additional","affiliation":[{"name":"Intervet International BV Wim de K\u00f6rverstraat 35, PO Box 31 5830AA Boxmeer The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. L. B. M.","family":"Klaasen","sequence":"additional","affiliation":[{"name":"Intervet International BV Wim de K\u00f6rverstraat 35, PO Box 31 5830AA Boxmeer The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,8,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0147-9571(90)90279-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.117.12.307"},{"key":"e_1_2_6_4_1","first-page":"1","volume-title":"Leptospira and Leptospirosis","author":"FAINE S.","year":"1994"},{"key":"e_1_2_6_5_1","first-page":"849","volume-title":"Topley and Wilson's Microbiology and Microbial Infections","author":"FAINE S.","year":"1998"},{"key":"e_1_2_6_6_1","first-page":"8","article-title":"A European perspective on leptospirosis","author":"FERGUSON I.","year":"1994","journal-title":"Microbiology Europe"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-32-6-495"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2427(84)90083-7"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2427(86)90078-4"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(65)90003-4"},{"key":"e_1_2_6_11_1","first-page":"62","volume-title":"Bergey's Manual of Systematic Bacteriology","author":"JOHNSON R. 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