{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:07:13Z","timestamp":1791328033893,"version":"4.3.1"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2003,8,16]],"date-time":"2003-08-16T00:00:00Z","timestamp":1060992000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["project 119 426\/122"],"award-info":[{"award-number":["project 119 426\/122"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:p>\n                    Five cases of scrapie with unusual features have been diagnosed in Norway since 1998. The affected sheep showed neurological signs dominated by ataxia, and had the PrP genotypes homozygous A\n                    <jats:sub>136<\/jats:sub>\n                    H\n                    <jats:sub>154<\/jats:sub>\n                    Q\n                    <jats:sub>171<\/jats:sub>\n                    \/ A\n                    <jats:sub>136<\/jats:sub>\n                    H\n                    <jats:sub>154<\/jats:sub>\n                    Q\n                    <jats:sub>171<\/jats:sub>\n                    or heterozygous A\n                    <jats:sub>136<\/jats:sub>\n                    H\n                    <jats:sub>I54<\/jats:sub>\n                    Q\n                    <jats:sub>171<\/jats:sub>\n                    \/A\n                    <jats:sub>136<\/jats:sub>\n                    R\n                    <jats:sub>154<\/jats:sub>\n                    Q\n                    <jats:sub>171<\/jats:sub>\n                    , which are rarely associated with scrapie. Brain histopathology revealed neuropil vacuolisation essentially in the cerebellar and cerebral cortices; vacuolation was less prominent in the brainstem, and no lesions were observed at the level of the obex. The deposits of PrP\n                    <jats:sup>Sc<\/jats:sup>\n                    were mainly in the cortex of the cerebellum and cerebrum, and no PrP\n                    <jats:sup>Sc<\/jats:sup>\n                    was detectable by immunohistochemistry and ELISA in the lymphoid tissues investigated. Western blot analysis showed that the glycotype was different from other known scrapie strains and from the BSE strain. From a diagnostic point of view, these features indicate that this type of scrapie, designated Nor98, could have been overlooked and may be of significance for sampling in scrapie surveillance programmes.\n                  <\/jats:p>","DOI":"10.1136\/vr.153.7.202","type":"journal-article","created":{"date-parts":[[2010,10,8]],"date-time":"2010-10-08T13:44:05Z","timestamp":1286545445000},"page":"202-208","source":"Crossref","is-referenced-by-count":377,"title":["Cases of scrapie with unusual features in Norway and designation of a new type, Nor98"],"prefix":"10.1002","volume":"153","author":[{"given":"S. L.","family":"Benestad","sequence":"first","affiliation":[{"name":"National Veterinary Institute Department of Pathology Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Sarradin","sequence":"additional","affiliation":[{"name":"INRA Tours\u2010Nouzilly France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Thu","sequence":"additional","affiliation":[{"name":"National Veterinary Institute Department of Pathology Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sch\u00f6nheit","sequence":"additional","affiliation":[{"name":"National Veterinary Institute Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Tranulis","sequence":"additional","affiliation":[{"name":"Department of Sheep and Goat Research Norwegian School of Veterinary Science Sandnes Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Bratberg","sequence":"additional","affiliation":[{"name":"National Veterinary Institute Department of Pathology Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,8,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-81-12-3115"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1099\/0022-1317-78-5-1187","article-title":"Evidence for an alternative direct route of access for the scrapie agent to the brain bypassing the spinal cord","volume":"5","author":"BALDAUF E.","year":"1997","journal-title":"Journal of General Virology"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.1.107-114.2001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.11.3701-3704.1999"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-76-3-509"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.3.1407-1414.2000"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90360-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-76-8-2097"},{"key":"e_1_2_8_10_1","first-page":"623","article-title":"Guidance on the use of PrP genotyping as an aid to the control of clinical scrapie","volume":"142","author":"DAWSON M.","year":"1998","journal-title":"Veterinary Record"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007050050516"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.40-2-164"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-82-1-267"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.148.6.165"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-82-10-2319"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(68)90006-6"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-75-5-989"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.149.19.577"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-80-1-1"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01718157"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.2002.0592"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/014107688207500809"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/515337"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1993.1006"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5298.402"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.2002.0589"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.19.9320-9327.2001"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/mpat.2000.0357"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(02)00073-5"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.6.1750-1755.1998"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64692-5"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6801762"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.148.1.7"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007062200"},{"key":"e_1_2_8_35_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1034\/j.1600-0463.2002.100105.x","article-title":"Influence of the prion protein gene, Prnp, on scrapie susceptibility in sheep","volume":"110","author":"TRANULIS M. 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