{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:18:27Z","timestamp":1790849907934,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,9,3]],"date-time":"2005-09-03T00:00:00Z","timestamp":1125705600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p>\n                    Dietary exposure to the bovine spongiform encephalopathy (\n                    <jats:sc>BSE<\/jats:sc>\n                    ) agent is the probable cause of variant Creutzfeldt\u2010Jakob disease in people. The industrial manufacturing process for the production of gelatine and colloidal protein by the heat and pressure process was downscaled accurately and its capacity to remove or inactivate\n                    <jats:sc>BSE<\/jats:sc>\n                    infectivity was investigated. Gelatine was made from bones experimentally contaminated with mouse brain infected with the 301V strain of mouse\u2010passaged\n                    <jats:sc>BSE<\/jats:sc>\n                    agent in which the infective titre was 10\n                    <jats:sup>8\u00b77<\/jats:sup>\n                    <jats:sc>ID50<\/jats:sc>\n                    \/g. No infectivity was detected in the extracted protein (\u226510\n                    <jats:sup>0\u00b745<\/jats:sup>\n                    <jats:sc>ID50<\/jats:sc>\n                    \/g), and the calculated clearance factor was 10\n                    <jats:sup>6\u00b75<\/jats:sup>\n                    <jats:sc>ID50<\/jats:sc>\n                    or more.\n                  <\/jats:p>","DOI":"10.1136\/vr.157.10.277","type":"journal-article","created":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T13:01:21Z","timestamp":1414069281000},"page":"277-281","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Inactivation of the BSE agent by the heat and pressure process for manufacturing gelatine"],"prefix":"10.1002","volume":"157","author":[{"given":"A. H.","family":"Grobben","sequence":"first","affiliation":[{"name":"Delft Gelatin p\/a Watergraaflaan 22 4731WH Oudenbosch The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J.","family":"Steele","sequence":"additional","affiliation":[{"name":"Neuropathogenesis Unit Institute for Animal Health West Mains Road Edinburgh EH9 3JF"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. A.","family":"Somerville","sequence":"additional","affiliation":[{"name":"Neuropathogenesis Unit Institute for Animal Health West Mains Road Edinburgh EH9 3JF"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Sedecon 2000, 147 Oxgangs Road North Edinburgh EH13 9DX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. E. C.","family":"Schreuder","sequence":"additional","affiliation":[{"name":"Institute for Animal Science and Health PO Box 65 8200 AB Leylystad The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,9,3]]},"container-title":["Veterinary Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1136%2Fvr.157.10.277","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/vr.157.10.277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T07:53:25Z","timestamp":1761638005000},"score":1,"resource":{"primary":{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/10.1136\/vr.157.10.277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["10.1136\/vr.157.10.277"],"URL":"https:\/\/doi.org\/10.1136\/vr.157.10.277","archive":["Portico"],"relation":{},"ISSN":["0042-4900","2042-7670"],"issn-type":[{"value":"0042-4900","type":"print"},{"value":"2042-7670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}