{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:49:10Z","timestamp":1763747350930,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2005,10,22]],"date-time":"2005-10-22T00:00:00Z","timestamp":1129939200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p>The potential efficacy of topical epsilon\u2010aminocaproic acid, an antiplasmin agent, in the treatment of persistent corneal epithelial defects was evaluated in a study of the medical records of 44 dogs, in which 51 eyes had been diagnosed with a corneal epithelial defect lasting more than 10\u00a0days, with no apparent underlying cause. At an initial examination all the affected eyes had had non\u2010adherent epithelium removed. Thirty\u2010four of the eyes in 28 dogs examined between January 2000 and March 2003 were also treated by the topical application of a solution of 35\u00b77\u00a0mg\/ml ophthalmic aminocaproic acid three times a day; the other 17 eyes in 16 dogs treated between October 1997 and March 1999 had received only topical treatment with gentamicin in addition to the debridement. Both groups were assessed clinically at weekly intervals for a maximum of three weeks. The two groups had approximately the same breed distribution, and there were no statistically significant differences between them in terms of their age, sex, affected side or duration of the corneal erosions. After three weeks, 32 of the 34 eyes treated with aminocaproic acid (94\u00b71 per cent) had been cured, compared with seven of the 17 eyes treated with gentamicin (41\u00b72 per cent) (P=0\u00b70001). No adverse drug reactions were reported.<\/jats:p>","DOI":"10.1136\/vr.157.17.510","type":"journal-article","created":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T13:01:21Z","timestamp":1414069281000},"page":"510-513","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Topical treatment of non\u2010healing corneal epithelial ulcers in dogs with aminocaproic acid"],"prefix":"10.1002","volume":"157","author":[{"given":"A.","family":"Regnier","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences National Veterinary School 23 Chemin des Capelles Toulouse Cedex 03 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Cazalot","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences National Veterinary School 23 Chemin des Capelles Toulouse Cedex 03 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Cantaloube","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences National Veterinary School 23 Chemin des Capelles Toulouse Cedex 03 France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,22]]},"container-title":["Veterinary Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1136%2Fvr.157.17.510","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/vr.157.17.510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T12:32:53Z","timestamp":1761654773000},"score":1,"resource":{"primary":{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/10.1136\/vr.157.17.510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10]]},"references-count":0,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["10.1136\/vr.157.17.510"],"URL":"https:\/\/doi.org\/10.1136\/vr.157.17.510","archive":["Portico"],"relation":{},"ISSN":["0042-4900","2042-7670"],"issn-type":[{"type":"print","value":"0042-4900"},{"type":"electronic","value":"2042-7670"}],"subject":[],"published":{"date-parts":[[2005,10]]}}}