{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:01:51Z","timestamp":1791028911987,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2006,4,22]],"date-time":"2006-04-22T00:00:00Z","timestamp":1145664000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2006,4]]},"abstract":"\n Recently, in the\n USA<\/jats:sc>\n , virulent mutants of feline calicivirus (\n FCV<\/jats:sc>\n ) have been identified as the cause of a severe and acute virulent systemic disease, characterised by jaundice, oedema and high mortality in groups of cats. This severe manifestation of\n FCV<\/jats:sc>\n disease has so far only been reported in the\n USA<\/jats:sc>\n . However, in 2003, an outbreak of disease affected a household of four adult cats and an adult cat from a neighbouring household in the\n UK<\/jats:sc>\n . Three of the adult cats in the household and the neighbouring cat developed clinical signs including pyrexia (39\u00b75 to 40\u00b75\u00b0C), lameness, voice loss, inappetence and jaundice. One cat was euthanased in extremis, two died and one recovered. A postmortem examination of one of the cats revealed focal cellulitis around the right hock and right elbow joints. The principal finding of histopathological examinations of selected organs from two of the cats was disseminated hepatocellular necrosis with mild inflammatory infiltration. Immunohistology identified\n FCV<\/jats:sc>\n antigen in parenchymal and Kupffer cells in the liver of both animals and in alveolar macrophages of one of them. In addition, calicivirus\u2010like particles were observed by electron microscopy within the hepatocytes of one cat.\n FCV<\/jats:sc>\n was isolated from two of the dead cats and from the two surviving cats. Sequence analysis showed that they were all infected with the same strain of virus, but that it was different from strains of\n FCV<\/jats:sc>\n associated with the virulent systemic disease in cats in the\n USA<\/jats:sc>\n . The outbreak was successfully controlled by quarantine in the owner\u2019s house.\n <\/jats:p>","DOI":"10.1136\/vr.158.16.544","type":"journal-article","created":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T04:50:42Z","timestamp":1286254242000},"page":"544-550","source":"Crossref","is-referenced-by-count":106,"title":["Lethal outbreak of disease associated with feline calicivirus infection in cats"],"prefix":"10.1002","volume":"158","author":[{"given":"K. P.","family":"Coyne","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathology University of Liverpool Veterinary Teaching Hospital Leahurst, Chester High Road Neston CH64 7TE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. R. D.","family":"Jones","sequence":"additional","affiliation":[{"name":"Park House Veterinary Centre 5\u00a0Park Street Stafford ST17 4AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kipar","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology University of Liverpool Veterinary Teaching Hospital Leahurst, Chester High Road Neston CH64 7TE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Chantrey","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology University of Liverpool Veterinary Teaching Hospital Leahurst, Chester High Road Neston CH64 7TE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J.","family":"Porter","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology University of Liverpool Veterinary Teaching Hospital Leahurst, Chester High Road Neston CH64 7TE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J.","family":"Barber","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences University of Liverpool Veterinary Teaching Hospital Leahurst, Chester High Road Neston CH64 7TE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Dawson","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences University of Liverpool Veterinary Teaching Hospital Leahurst, Chester High Road Neston CH64 7TE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. M.","family":"Gaskell","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology University of Liverpool Veterinary Teaching Hospital Leahurst, Chester High Road Neston CH64 7TE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. D.","family":"Radford","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences University of Liverpool Veterinary Teaching Hospital Leahurst, Chester High Road Neston CH64 7TE"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,4,22]]},"container-title":["Veterinary Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1136%2Fvr.158.16.544","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/vr.158.16.544","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T09:44:05Z","timestamp":1761644645000},"score":1,"resource":{"primary":{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/10.1136\/vr.158.16.544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":0,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1136\/vr.158.16.544"],"URL":"https:\/\/doi.org\/10.1136\/vr.158.16.544","archive":["Portico"],"relation":{},"ISSN":["0042-4900","2042-7670"],"issn-type":[{"value":"0042-4900","type":"print"},{"value":"2042-7670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4]]}}}