{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:46:45Z","timestamp":1770745605739,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,1,28]],"date-time":"2006-01-28T00:00:00Z","timestamp":1138406400000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p>Over the course of one year, slight jaundice and ascites suggestive of chronic liver disease occurred in 17 German shepherd dogs from one breeding colony. Blood analyses, performed twice with a six\u2010month interval, revealed elevated serum activities of liver enzymes in 13 dogs. In addition, four young adult German shepherd dogs that showed severe ascites, slight jaundice and increased serum liver enzyme activities were referred for further evaluation. Because of their poor prognosis these four dogs were euthanased. There were no signs of photosensitivity. Postmortem examinations revealed macronodular darkened livers, which were characterised histopathologically by cirrhosis associated with aggregates of brown pigments showing a striking orange birefringence in polarised light. Ultrastructurally, the crystalline pigments were typical of protoporphyrins. High\u2010performance liquid chromatographic analysis of liver samples revealed very high levels of protoporphyrins (mean 9550\u00a0nmol\/g wet liver, reference value 0\u00b741\u00a0nmol\/g wet liver) and low activities of ferrochelatase (mean 0\u00b7274\u00a0mmol\/mg protein\/hour, reference value 0\u00b7684\u00a0nmol\/mg protein\/hour). Twenty\u2010six months after the onset of the hepatopathies, the clinical condition of the 13 surviving dogs had improved and their serum liver enzyme activities were normal. The clinical histories and pedigree analyses were not in concordance with an inherited form of protoporphyria. There was no known history of exposure to toxic substances or drugs. The findings are in accordance with a transient erythropoietic protoporphyria associated with hepatic complications, presumably caused by exposure to a porphyrinogenic, ferrochelatase\u2010inhibitory substance of unknown origin.<\/jats:p>","DOI":"10.1136\/vr.158.4.120","type":"journal-article","created":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T04:50:42Z","timestamp":1286254242000},"page":"120-124","source":"Crossref","is-referenced-by-count":9,"title":["Transient erythropoietic protoporphyria associated with chronic hepatitis and cirrhosis in a cohort of German shepherd dogs"],"prefix":"10.1002","volume":"158","author":[{"given":"E. J. B. Veldhuis","family":"Kroeze","sequence":"first","affiliation":[{"name":"Pathology Division Department of Pathobiology Utrecht University Yalelaan 8 3584 CM Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Zentek","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition School of Veterinary Medicine Hannover Bischofsholer Damm 15 D\u201030173 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Edixhoven\u2010Bosdijk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Erasmus MC University Medical Centre Rotterdam Dr Molewaterplein 40 3015 GD Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Rothuizen","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences of Companion Animals Faculty of Veterinary Medicine Utrecht University Yalelaan 8 3584 CM Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. S. G. A. M.","family":"van den Ingh","sequence":"additional","affiliation":[{"name":"Pathology Division Department of Pathobiology Utrecht University Yalelaan 8 3584 CM Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,28]]},"container-title":["Veterinary Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1136%2Fvr.158.4.120","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/vr.158.4.120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T07:08:06Z","timestamp":1761635286000},"score":1,"resource":{"primary":{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/10.1136\/vr.158.4.120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1136\/vr.158.4.120"],"URL":"https:\/\/doi.org\/10.1136\/vr.158.4.120","archive":["Portico"],"relation":{},"ISSN":["0042-4900","2042-7670"],"issn-type":[{"value":"0042-4900","type":"print"},{"value":"2042-7670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}