{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:48:15Z","timestamp":1761662895615,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T00:00:00Z","timestamp":1139011200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p>\n                    To determine whether there is an effect of the timing of vaccination on porcine circovirus type 2 (\n                    <jats:sc>PCV\u20102<\/jats:sc>\n                    ) replication and\n                    <jats:sc>PCV\u20102<\/jats:sc>\n                    \u2010associated lesions, 78 pigs were randomly assigned to eight groups: group 1 (10 pigs) was vaccinated with a commercial\n                    <jats:italic>Mycoplasma hyopneumoniae<\/jats:italic>\n                    vaccine at two and four weeks of age, group 2 (nine pigs) was vaccinated at four and six weeks of age, group 3 (10 pigs) at six and eight weeks of age and group 4 (10 pigs) at eight and 10 weeks of age; group 5 (nine pigs) was vaccinated once with a double dose at four weeks of age, and group 6 (10 pigs) was vaccinated once with a double dose at eight weeks of age. Groups 7 and 8, both of 10 pigs, were not vaccinated. At eight weeks of age, the pigs in groups 1 to 7 were inoculated with\n                    <jats:sc>PCV\u20102<\/jats:sc>\n                    . Fourteen days after they had been inoculated, the pigs in groups 1, 4 and 5 had significantly (P&lt;0\u00b705) more copies of the\n                    <jats:sc>PCV\u20102<\/jats:sc>\n                    genome in their serum than the unvaccinated pigs. Microscopically, 14 of the 68\u00a0inoculated pigs had normal lymphoid tissues, 40 had mild\n                    <jats:sc>PCV\u20102<\/jats:sc>\n                    \u2010associated lymphoid lesions and 14 had moderate lesions. The mean overall lymphoid lesions (lymphoid depletion, granulomatous inflammation, and quantity of\n                    <jats:sc>PCV\u20102<\/jats:sc>\n                    antigen in spleen, tonsil, and five lymph nodes) were significantly (P&lt;0\u00b705) more severe in groups 4 and 5 than in groups 2, 3, 7 and 8.\n                  <\/jats:p>","DOI":"10.1136\/vr.158.5.149","type":"journal-article","created":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T04:50:42Z","timestamp":1286254242000},"page":"149-154","source":"Crossref","is-referenced-by-count":35,"title":["Effects of the timing of the administration of\n                    <i>Mycoplasma hyopneumoniae<\/i>\n                    bacterin on the development of lesions associated with porcine circovirus type 2"],"prefix":"10.1002","volume":"158","author":[{"given":"T.","family":"Opriessnig","sequence":"first","affiliation":[{"name":"Department of Veterinary Diagnostic and Production Animal Medicine College of Veterinary Medicine Iowa State University Ames IA 50011 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. G.","family":"Halbur","sequence":"additional","affiliation":[{"name":"Department of Veterinary Diagnostic and Production Animal Medicine College of Veterinary Medicine Iowa State University Ames IA 50011 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Microbiology and Preventive Medicine College of Veterinary Medicine Iowa State University Ames IA 50011 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. L.","family":"Thacker","sequence":"additional","affiliation":[{"name":"Department of Veterinary Microbiology and Preventive Medicine College of Veterinary Medicine Iowa State University Ames IA 50011 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Fenaux","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Pathobiology Center of Molecular Medicine and Infectious Diseases College of Veterinary Medicine Virginia Polytechnic Institute and State University Blacksburg VA 24061\u201003542 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X. J.","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Pathobiology Center of Molecular Medicine and Infectious Diseases College of Veterinary Medicine Virginia Polytechnic Institute and State University Blacksburg VA 24061\u201003542 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,2,4]]},"container-title":["Veterinary Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1136%2Fvr.158.5.149","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/vr.158.5.149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T07:16:00Z","timestamp":1761635760000},"score":1,"resource":{"primary":{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/10.1136\/vr.158.5.149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1136\/vr.158.5.149"],"URL":"https:\/\/doi.org\/10.1136\/vr.158.5.149","archive":["Portico"],"relation":{},"ISSN":["0042-4900","2042-7670"],"issn-type":[{"type":"print","value":"0042-4900"},{"type":"electronic","value":"2042-7670"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}