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Experimental exposure of the skin of a cow to calcium cyanamide induced the same type of contact dermatitis, and histopathological investigations showed that it caused irritant and allergic reactions. To identify the cause of the dermatitis, a patch test with calcium cyanamide and its breakdown products, cyanamide, urea and ammonium bicarbonate, was carried out on four cows. Three of them had a positive reaction to calcium cyanamide and cyanamide; delayed and amplified reactions suggesting an allergic response were observed.<\/jats:p>","DOI":"10.1136\/vr.163.14.418","type":"journal-article","created":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T17:36:25Z","timestamp":1286300185000},"page":"418-422","source":"Crossref","is-referenced-by-count":11,"title":["Contact dermatitis in dairy cattle caused by calcium cyanamide"],"prefix":"10.1002","volume":"163","author":[{"given":"K.","family":"Onda","sequence":"first","affiliation":[{"name":"Laboratory of Internal Medicine III"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Yagisawa","sequence":"additional","affiliation":[{"name":"Laboratory of Internal Medicine III"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Matsui","sequence":"additional","affiliation":[{"name":"Northern Clinical Centre Chiba Prefectural Foundation of Agricultural and Mutual Aid Association 99\u20101\u00a0Makino Katori Chiba 289\u20100407 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Northern Clinical Centre Chiba Prefectural Foundation of Agricultural and Mutual Aid Association 99\u20101\u00a0Makino Katori Chiba 289\u20100407 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Yako","sequence":"additional","affiliation":[{"name":"Northern Clinical Centre Chiba Prefectural Foundation of Agricultural and Mutual Aid Association 99\u20101\u00a0Makino Katori Chiba 289\u20100407 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Une","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology Azabu University School of Veterinary Medicine 1\u201017\u201071 Fuchinobe Sagamihara Kanagawa 229\u20108501 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Wada","sequence":"additional","affiliation":[{"name":"Laboratory of Internal Medicine III"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,10,4]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.1111\/j.1600-0536.1994.tb02037.x"},{"key":"e_1_2_6_3_1","first-page":"311","article-title":"Fatal calcium cyanide poisoning and the problem of disturbed decomposition of alcohol","volume":"14","author":"Hauschild F.","year":"1953","journal-title":"South African Journal of Clinical Science"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1136\/vr.154.7.208"},{"key":"e_1_2_6_5_1","first-page":"412","volume-title":"New Veterinary Handbook","author":"Iizuka M.","year":"1997"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_1","DOI":"10.1023\/A:1022621709486"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_1","DOI":"10.1159\/000245680"},{"key":"e_1_2_6_8_1","first-page":"345","volume-title":"Veterinary Laboratory Medicine","author":"Meyer D. 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