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There were no significant differences between the mean serum concentrations of phenobarbitone in the trough and non\u2010trough samples from dogs receiving doses ranging from 2\u00a0mg\/kg per day to more than 10\u00a0mg\/kg per day. However, the higher doses of phenobarbitone were associated with progressively lower phenobarbitone concentrations in the trough group relative to the non\u2010trough group, and this difference was significant at doses of more than 10\u00a0mg\/kg per day.<\/jats:p>","DOI":"10.1136\/vr.165.19.556","type":"journal-article","created":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T17:44:04Z","timestamp":1286300644000},"page":"556-558","source":"Crossref","is-referenced-by-count":11,"title":["Variations in serum concentration of phenobarbitone in dogs receiving regular twice daily doses in relation to the times of administration"],"prefix":"10.1002","volume":"165","author":[{"given":"R.","family":"Monteiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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