{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T21:18:29Z","timestamp":1778707109270,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2009,11,14]],"date-time":"2009-11-14T00:00:00Z","timestamp":1258156800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Swiss Club"},{"name":"Albert Heim Foundation and Novartis Animal Health Switzerland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:p>\n                    A commercial immunoassay for antibodies to the C6 antigen of\n                    <jats:italic>Borrelia burgdorferi<\/jats:italic>\n                    was evaluated against an IgG in\u2010house ELISA in combination with a Western blot assay to examine 104 samples of serum from 53 healthy Bernese mountain dogs, which were suspected to have a breed predisposition to Lyme borreliosis, and 55 samples from 30 healthy large\u2010breed longhair dogs. The two test methods correlated in 125 (79 per cent) of the samples with an agreement of kappa=0\u00b7571 (P&lt;0\u00b7001). In comparison with the in\u2010house ELISA in combination with a Western blot, the sensitivity and specificity of the C6 test were 81 per cent and 77 per cent respectively. The agreement between the tests was better with the samples from the Bernese mountain dogs (k=0\u00b7681) than with the samples from the control dogs (k=0\u00b7347).\n                  <\/jats:p>","DOI":"10.1136\/vr.165.20.594","type":"journal-article","created":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T17:44:04Z","timestamp":1286300644000},"page":"594-597","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of a rapid immunoassay for antibodies to the C6 antigen with conventional tests for antibodies to\n                    <i>Borrelia burgdorferi<\/i>\n                    in dogs in Europe"],"prefix":"10.1002","volume":"165","author":[{"given":"B.","family":"Gerber","sequence":"first","affiliation":[{"name":"Clinic for Small Animal Internal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Haug","sequence":"additional","affiliation":[{"name":"Clinic for Small Animal Internal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Eichenberger","sequence":"additional","affiliation":[{"name":"Clinic for Small Animal Internal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. E.","family":"Reusch","sequence":"additional","affiliation":[{"name":"Clinic for Small Animal Internal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"Wittenbrink","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Bacteriology Vetsuisse Faculty University of Zurich Winterthurerstrasse 260 8057 Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,11,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/374395"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/169.2.313"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063879901100309"},{"key":"e_1_2_6_5_1","first-page":"15","article-title":"Increased prevalence of Borrelia burgdorferi infections in Bernese Mountain dogs: a possible breed disposition","volume":"3","author":"Gerber B.","year":"2007","journal-title":"BioMed Central Veterinary Research"},{"key":"e_1_2_6_6_1","first-page":"18","article-title":"Follow\u2010up of Bernese Mountain dogs and other dogs with serologically diagnosed Borrelia burgdorferi infection: what happens to seropositive animals?","volume":"5","author":"Gerber B.","year":"2009","journal-title":"BioMed Central Veterinary Research"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063870701900312"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.3.844-848.2001"},{"key":"e_1_2_6_9_1","first-page":"417","volume-title":"Infectious Diseases of the Dog and the Cat","author":"Greene C. E.","year":"2006"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1128\/JCM.38.7.2628-2632.2000","article-title":"Quantitative approach for the serodiagnosis of canine Lyme disease by the immunoblot procedure","volume":"38","author":"Guerra M.","year":"2000","journal-title":"Journal of Clinical Microbiology"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.35.6.1433-1444.1997"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-2867(96)80030-2"},{"key":"e_1_2_6_13_1","first-page":"776","article-title":"Tick\u2010transmitted, bacterial infections in dogs: seroprevalences of Anaplasma phagocytophilum, Borrelia burgdorferi sensu lato and Ehrlichia canis in Germany","volume":"88","author":"Krupka I.","year":"2007","journal-title":"Praktische Tierarzt"},{"key":"e_1_2_6_14_1","first-page":"308","article-title":"Utility of an inoffice C6 Elisa test kit for determination of infection status of dogs naturally exposed to Borrelia burgdorferi","volume":"3","author":"Levy S.","year":"2002","journal-title":"Veterinary Therapeutics"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/315862"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1128\/JCM.38.11.4160-4166.2000","article-title":"Characterization of a Borrelia burgdorferi VlsE invariable region useful in canine Lyme disease serodiagnosis by enzyme\u2010linked immunosorbent assay","volume":"38","author":"Liang F. T.","year":"2000","journal-title":"Journal of Clinical Microbiology"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.12.3990-3996.1999"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.81.11.1448"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2006.tb02880.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.5.1735-1739.2000"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.7.2591-2593.2002"},{"key":"e_1_2_6_22_1","first-page":"458","article-title":"Dogs vaccinated with common Lyme disease vaccines do not respond to IR6, the conserved immunodominant region of the VlsE surface protein of Borrelia burgdorferi","volume":"11","author":"O\u2019Connor T. P.","year":"2004","journal-title":"Clinical and Diagnostic Laboratory Immunology"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/323392"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.6.2097-2102.2000"},{"key":"e_1_2_6_25_1","doi-asserted-by":"crossref","first-page":"4086","DOI":"10.1128\/JCM.37.12.4086-4092.1999","article-title":"Scored antibody reactivity determined by immunoblotting shows an association between clinical manifestations and the presence of Borrelia burgdorferi sensu stricto, B garinii, B afzelli, and B valaisiana in humans","volume":"37","author":"Ryffel K.","year":"1999","journal-title":"Journal of Clinical Microbiology"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2006.10.017"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14798-8"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200107123450207"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1086\/315340"},{"key":"e_1_2_6_30_1","first-page":"257","article-title":"Enzyme\u2010linked immunosorbent assay and immunoblot analysis for detection of antibodies to Borrelia burgdorferi in dogs","volume":"48","author":"Wittenbrink M. M.","year":"1996","journal-title":"The impact of serum absorption with homologous and heterologous bacteria. Veterinary Microbiology"}],"container-title":["Veterinary Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/vr.165.20.594","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1136\/vr.165.20.594","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1136%2Fvr.165.20.594","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/vr.165.20.594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T09:53:48Z","timestamp":1761645228000},"score":1,"resource":{"primary":{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/10.1136\/vr.165.20.594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":29,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.1136\/vr.165.20.594"],"URL":"https:\/\/doi.org\/10.1136\/vr.165.20.594","archive":["Portico"],"relation":{},"ISSN":["0042-4900","2042-7670"],"issn-type":[{"value":"0042-4900","type":"print"},{"value":"2042-7670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}