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The dogs received selamectin at a dose of 24 to 48\u00a0mg\/kg once a week, or the same dose every two weeks. Thirty\u2010eight dogs completed the study, four dogs were lost to follow\u2010up and two dogs died. Nine dogs went into remission: all had the juvenile\u2010onset form of the disease. There was no difference between the two treatment groups, but dogs with clinical scores of 65 or less responded significantly better than those with a score of over 65 (P=0.0015). The most frequent adverse effects were vomiting and diarrhoea. Two dogs exhibited mild reversible neurological side effects, which resolved with cessation of treatment. Difficulties in oral administration were observed in several dogs.<\/jats:p>","DOI":"10.1136\/vr.4850","type":"journal-article","created":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T17:52:18Z","timestamp":1286301138000},"page":"710-714","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Oral selamectin in the treatment of canine generalised demodicosis"],"prefix":"10.1002","volume":"166","author":[{"given":"B.","family":"Schnabl","sequence":"first","affiliation":[{"name":"Small Animal Medical Clinic Ludwig Maximilian University Veterin\u00e4rstrasse 13 80539 Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bettenay","sequence":"additional","affiliation":[{"name":"Tier\u00e4rztliche Fachklinik f\u00fcr Kleintiere Industriestrasse 6 81220 Germering Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Glos","sequence":"additional","affiliation":[{"name":"Tier\u00e4rztliche Fachklinik f\u00fcr Kleintiere Industriestrasse 6 81220 Germering Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Linek","sequence":"additional","affiliation":[{"name":"Tier\u00e4rztliche Spezialisten Hamburg Rodigallee 85\/Holstenhofweg 22043 Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Loewenstein","sequence":"additional","affiliation":[{"name":"Tierklinik Hofheim Im Langgewann 9 65719 Hofheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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