{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:56:06Z","timestamp":1789192566529,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2010,10,2]],"date-time":"2010-10-02T00:00:00Z","timestamp":1285977600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:p>This paper describes the nematode control strategy adopted by a Scottish hill sheep farmer. It provides an example of the limited use of anthelmintic drugs, targeted towards control of the periparturient rise in faecal nematode egg output in ewes and exploitation of grazing management, resulting in limited exposure of naive sheep to infective larvae on pasture. Resistance to benzimidazole, imidazothiazole and macrocyclic lactone anthelmintics, and to a combination of a macrocyclic lactone and imidazothiazole anthelmintic drugs was diagnosed. The targeted use of a persistent anthelmintic drug to control a periparturient rise in faecal nematode egg output in ewes may be unnecessary and selects strongly for resistance when the reservoir of anthelmintic\u2010susceptible nematodes in refugia is small at the time of treatment. However, the use of a persistent anthelmintic drug in a selective proportion of ewes can be important and probably does not select strongly for resistance when the reservoir of anthelmintic\u2010susceptible nematodes in refugia is large at the time of treatment. The former circumstances might arise on many Scottish hill sheep farms, whereas the latter may occur on upland and lowground farms, depending on previous grazing management, anthelmintic use and winter weather conditions. These factors must be taken into account when preparing sustainable health plans for nematode parasite control in individual sheep flocks.<\/jats:p>","DOI":"10.1136\/vr.c4478","type":"journal-article","created":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T17:52:18Z","timestamp":1286301138000},"page":"523-527","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["<i>Teladorsagia circumcincta<\/i>\n                    resistance to moxidectin and multiple anthelmintic groups in ewes following use of the persistent drug before lambing"],"prefix":"10.1002","volume":"167","author":[{"given":"N. D.","family":"Sargison","sequence":"first","affiliation":[{"name":"Large Animal Practice Royal (Dick) School of Veterinary Studies Easter Bush Veterinary Centre University of Edinburgh Roslin Midlothian EH25 9RG"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. R.","family":"Scott","sequence":"additional","affiliation":[{"name":"Large Animal Practice Royal (Dick) School of Veterinary Studies Easter Bush Veterinary Centre University of Edinburgh Roslin Midlothian EH25 9RG"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Large Animal Practice Royal (Dick) School of Veterinary Studies Easter Bush Veterinary Centre University of Edinburgh Roslin Midlothian EH25 9RG"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. I.","family":"Macrae","sequence":"additional","affiliation":[{"name":"Large Animal Practice Royal (Dick) School of Veterinary Studies Easter Bush Veterinary Centre University of Edinburgh Roslin Midlothian EH25 9RG"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. D.","family":"Penny","sequence":"additional","affiliation":[{"name":"Large Animal Practice Royal (Dick) School of Veterinary Studies Easter Bush Veterinary Centre University of Edinburgh Roslin Midlothian EH25 9RG"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,10,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(01)00174-6"},{"key":"e_1_2_5_3_1","first-page":"94","article-title":"Anthelmintic\u2010resistant nematodes in sheep in Scotland.","volume":"149","author":"Bartley D.","year":"2001","journal-title":"Veterinary Record"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2004.06.018"},{"key":"e_1_2_5_5_1","first-page":"195","article-title":"Ivermectin resistant Ostertagia in Western Australia.","volume":"26","author":"Besier R. B.","year":"1996","journal-title":"Proceedings of the Sheep and Beef Cattle Society of the New Zealand Veterinary Association"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.161.1.36-b"},{"key":"e_1_2_5_7_1","first-page":"604","article-title":"Multiresistant nematodes on a Devon farm.","volume":"153","author":"Cheng Y.","year":"2003","journal-title":"Veterinary Record"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(92)90141-U"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2005.11.019"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0021859600041782"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.92.18.469"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2005.36475"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2004.36430"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2009.03.027"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2006.36712"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(99)00074-0"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2006.36714"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(95)00059-3"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.1997.36038"},{"key":"e_1_2_5_20_1","volume-title":"Manual of Veterinary Parasitological Laboratory Techniques","author":"MAFF","year":"1986"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1989.tb13578.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2009.06.007"},{"key":"e_1_2_5_23_1","volume-title":"Proceedings of the Fifth International Congress for Sheep Veterinarians","author":"Palmer D. G.","year":"2001"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.130.12.241"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2006.36709"},{"key":"e_1_2_5_26_1","first-page":"163","article-title":"Studies in Scottish hill sheep.","volume":"85","author":"Reid J. F.","year":"1975","journal-title":"I. Changes in the susceptibility of the breeding ewe to Ostertagia spp. Journal of Comparative Pathology"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(18)33583-5"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2006.36716"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1970.tb06637.x"},{"key":"e_1_2_5_30_1","first-page":"778","article-title":"Multiple anthelmintic resistance in sheep.","volume":"149","author":"Sargison N.","year":"2001","journal-title":"Veterinary Record"},{"key":"e_1_2_5_31_1","first-page":"343","article-title":"Ivermectin resistance in a terminal sire sheep flock.","volume":"155","author":"Sargison N. D.","year":"2004","journal-title":"Veterinary Record"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.156.4.105"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2006.10.024"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.151.12.353"},{"key":"e_1_2_5_35_1","first-page":"788","article-title":"Nematodiriosis and spring teladorsagiosis in lambs.","volume":"152","author":"Sargison N. D.","year":"2003","journal-title":"Veterinary Record"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.133.18.445"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-6226(97)00105-X"},{"key":"e_1_2_5_38_1","first-page":"55","article-title":"Refugia \u2010 overlooked as perhaps the most potent factor concerning the development of anthelmintic resistance.","volume":"68","author":"Van Wyk J. A.","year":"2001","journal-title":"Onderstepoort Journal of Veterinary Research"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2003.11.012"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2001.36235"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2006.36710"},{"key":"e_1_2_5_42_1","first-page":"95","article-title":"Economic solutions for hill sheep farms.","volume":"30","author":"Waterhouse A.","year":"2006","journal-title":"Proceedings of the Sheep Veterinary Society"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.161.15.535-a"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.162.17.546"}],"container-title":["Veterinary Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1136%2Fvr.c4478","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/vr.c4478","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T09:20:34Z","timestamp":1761643234000},"score":1,"resource":{"primary":{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/10.1136\/vr.c4478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":43,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["10.1136\/vr.c4478"],"URL":"https:\/\/doi.org\/10.1136\/vr.c4478","archive":["Portico"],"relation":{},"ISSN":["0042-4900","2042-7670"],"issn-type":[{"value":"0042-4900","type":"print"},{"value":"2042-7670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}