{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T14:11:08Z","timestamp":1761574268457,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2010,10,9]],"date-time":"2010-10-09T00:00:00Z","timestamp":1286582400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:p>\n                    Disease\u2010related stress associated with\n                    <jats:italic>Fasciola gigantica<\/jats:italic>\n                    infection was investigated in 16\u00a0male, yearling Murrah buffaloes. The animals were randomly assigned to one of four groups. Animals in groups 1 and 2 were vaccinated subcutaneously with 4.8\u00a0mg of excretory\u2010secretory antigen (group 1) or 1300 \u03bcg infection\u2010specific antigen (group 2), in three doses. Subsequently, all the animals in groups 1, 2 and 3 were infected orally with 800 viable\n                    <jats:italic>F gigantica<\/jats:italic>\n                    metacercariae (bubaline origin) on week 6 of the experiment. The animals in group 4 served as healthy controls. The clinical progress of the disease with respect to the adrenocortical response to infection was assessed periodically. The infected animals in group 3 developed characteristic signs of the disease and had the highest in situ fluke population (mean [se] 331.8 [19.5]). One of the four animals in group 3 died on day 110 postinfection (PI). Animals that had been immunised before infection (groups 1 and 2) acquired adequate levels of immunity, were comparatively healthier and had significantly lower (P&lt;0.05) fluke populations (mean [se] 194.3 [11.8] in group 1 and 164.5 [9.2] in group 2). Throughout the course of the disease, the group 3 animals had significantly higher cortisol levels than those in groups 1 and 2 (P&lt;0.01) from week 4\u00a0PI onward. Although animals in the immunised groups (groups 1 and 2) had increased hormone levels, they were not significantly different from those in the control animals in group 4. Cortisol levels were higher during the early prepatency phase (weeks 1 to 6\u00a0PI) than during the late prepatency and\/or patency phases of the disease. Cortisol levels in the healthy control animals in group 4\u00a0remained within the normal range.\n                  <\/jats:p>","DOI":"10.1136\/vr.c4523","type":"journal-article","created":{"date-parts":[[2010,10,9]],"date-time":"2010-10-09T13:22:56Z","timestamp":1286630576000},"page":"571-575","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Tropical liver fluke\u2010induced stress in experimentally infected and immunised buffaloes"],"prefix":"10.1002","volume":"167","author":[{"given":"R.","family":"Edith","sequence":"first","affiliation":[{"name":"Division of Parasitology Indian Veterinary Research Institute Izatnagar 243122 Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. B.","family":"Thilagar","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine Madras Veterinary College Chennai 600007 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Godara","sequence":"additional","affiliation":[{"name":"Department of Veterinary Parasitology Apollo College of Veterinary Medicine Agra Road Jaipur 302031 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. L.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Veterinary Parasitology Apollo College of Veterinary Medicine Agra Road Jaipur 302031 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,10,9]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"280","volume-title":"Merck Veterinary Manual","author":"Aiello S. 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