{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:34:46Z","timestamp":1791264886484,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2011,4,2]],"date-time":"2011-04-02T00:00:00Z","timestamp":1301702400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p>\n                    The prevalence of carriage of antimicrobial\u2010resistant (AMR) and extended\u2010spectrum \u03b2\u2010lactamase (ESBL)\u2010producing\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    was determined in 183 healthy dogs from a semi\u2010rural community in Cheshire. Isolates were tested against a panel of antimicrobials and by PCR to detect resistance genes. In the suspected ESBL\u2010producing isolates, the presence of\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>SHV<\/jats:sub>\n                    ,\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>TEM<\/jats:sub>\n                    ,\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>CTX\u2010M<\/jats:sub>\n                    and\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>AmpC<\/jats:sub>\n                    genes was determined by PCR and sequencing. A total of 53 (29 per cent, 95 per cent confidence interval [CI] 22.4 to 35.5 per cent) dogs carried at least one AMR\n                    <jats:italic>E coli<\/jats:italic>\n                    isolate. Twenty\u2010four per cent (95 per cent CI 17.9 to 30.2 per cent) of dogs carried isolates resistant to ampicillin, 19.7 per cent (95 per cent CI 13.9 to 25.4 per cent) to tetracycline and 16.9 per cent (95 per cent CI 11.5 to 22.4 per cent) to trimethoprim. A\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>TEM<\/jats:sub>\n                    gene was detected in 39 of 54\u00a0ampicillin\u2010resistant isolates, a\n                    <jats:italic>tet(B)<\/jats:italic>\n                    gene in 12 of 45 tetracycline\u2010resistant isolates, and a\n                    <jats:italic>dfr<\/jats:italic>\n                    gene in 22 of 33 trimethoprim\u2010resistant isolates. Multidrug\u2010resistant isolates were demonstrated in 15 per cent (28 of 183; 95 per cent CI 10.1 to 20.5 per cent) of dogs. Nine suspected ESBL\u2010producing\n                    <jats:italic>E coli<\/jats:italic>\n                    were isolated, of which only one was confirmed by double disc diffusion testing. Two of these isolates carried the\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>TEM\u20101<\/jats:sub>\n                    gene and seven carried the\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>CMY\u20102<\/jats:sub>\n                    gene.\n                  <\/jats:p>","DOI":"10.1136\/vr.d1540","type":"journal-article","created":{"date-parts":[[2011,3,23]],"date-time":"2011-03-23T20:49:35Z","timestamp":1300913375000},"page":"354-354","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":45,"title":["Prevalence of antimicrobial\u2010resistant\n                    <i>Escherichia coli<\/i>\n                    in dogs in a cross\u2010sectional, community\u2010based study"],"prefix":"10.1002","volume":"168","author":[{"given":"A. L.","family":"Wedley","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Population Health Research University of Liverpool Leahurst Campus Neston Cheshire CH64 7TE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. W.","family":"Maddox","sequence":"additional","affiliation":[{"name":"School of Veterinary Science University of Liverpool Leahurst Campus Neston Cheshire CH64 7TE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Westgarth","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Research University of Liverpool Leahurst Campus Neston Cheshire CH64 7TE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. P.","family":"Coyne","sequence":"additional","affiliation":[{"name":"Department of Infection Biology Research Institute of Infection and Global Health University of Liverpool Leahurst Campus Neston Cheshire CH64 7TE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. L.","family":"Pinchbeck","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Research University of Liverpool Leahurst Campus Neston Cheshire CH64 7TE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. J.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Research University of Liverpool Leahurst Campus Neston Cheshire CH64 7TE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Dawson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Research University of Liverpool Leahurst Campus Neston Cheshire CH64 7TE"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm110"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2005.06.027"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.1998.00201.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.10.3758-3764.2004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2007.00242.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2007.08.004"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/107662904323047826"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.228.12.1909"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2007.00991.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.1.88-95.2001"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.12.3059"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh332"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1135(02)00263-8"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/47.5.599"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.5.1630-1634.2006"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/107662904323047745"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01857.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/45.6.881"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.62.9.3350-3354.1996"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07322-4"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2007.11.009"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2007.11.011"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2005.10.004"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcpr.2001.0363"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5877(00)00149-5"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.146.6.151"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm269"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.6.2153-2162.2002"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.1.1-11.2002"},{"key":"e_1_2_6_31_1","first-page":"11","volume-title":"Proceedings of the 6th International Symposium on New Quinolones","author":"Piddock L. J. V.","year":"1998"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01647-05"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.10.3996-4001.2004"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46888-0"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl057"},{"key":"e_1_2_6_36_1","unstructured":"SVA(2006)Swedish Veterinary Antimicrobial Resistance Monitoring 2006. National Veterinary Institute (SVA).www.sva.se\/upload\/pdf\/Tj%C3%A4nster%20och%20produkter\/Trycksaker\/svarm2006.pdf. Accessed November 16 2010"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(00)00145-X"},{"key":"e_1_2_6_38_1","unstructured":"VMD(2000)Sales of antimicrobial products used as veterinary medicines growth promoters and coccidiostats In the UK from 1993\u20131998.www.vmd.gov.uk\/pdf\/salesanti9398.pdf. Accessed October 27 2009"},{"key":"e_1_2_6_39_1","unstructured":"VMD(2009)Sales of antimicrobial products authorised for use as veterinary medicines antiprotazoals antifungals and coccidiostats in the UK in 2008.www.vmd.gov.uk\/pdf\/salesanti08.pdf. Accessed November 3 2009"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-3-5"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.165.18.526"}],"container-title":["Veterinary Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1136%2Fvr.d1540","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/vr.d1540","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T08:02:17Z","timestamp":1761638537000},"score":1,"resource":{"primary":{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/10.1136\/vr.d1540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":40,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1136\/vr.d1540"],"URL":"https:\/\/doi.org\/10.1136\/vr.d1540","archive":["Portico"],"relation":{},"ISSN":["0042-4900","2042-7670"],"issn-type":[{"value":"0042-4900","type":"print"},{"value":"2042-7670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}