{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:08:19Z","timestamp":1791374899227,"version":"4.3.1"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,7,16]],"date-time":"2011-07-16T00:00:00Z","timestamp":1310774400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:p>\n                    The susceptibility to an initial challenge and a re\u2010challenge inoculation with\n                    <jats:italic>Actinobacillus pleuropneumoniae<\/jats:italic>\n                    was analysed in pigs that were treated with antimicrobials of different efficacies following the first exposure to\n                    <jats:italic>A pleuropneumoniae<\/jats:italic>\n                    . In brief, 30\u00a0nine\u2010week\u2010old specific pathogen\u2010free pigs were allocated to five groups of six. After acclimatisation, four groups were inoculated with\n                    <jats:italic>A pleuropneumoniae<\/jats:italic>\n                    serotype 2. At the onset of clinical signs, three of the groups of pigs were treated with enrofloxacin, tetracycline or penicillin. A fourth group served as the inoculated control and the fifth group as a control group that had not been inoculated. On day 28, all five groups were re\u2010challenged with the same strain of\n                    <jats:italic>A pleuropneumoniae<\/jats:italic>\n                    serotype 2 as had been used in the first inoculation. No treatments were carried out at this time. The acute phase responses and differential leucocyte counts were monitored in detail after both inoculations. Leucocytosis and acute phase responses in the forms of serum amyloid A, pig\u2010major acute phase protein and haptoglobin were recorded in all of the inoculated groups after the onset of clinical signs following the first inoculation. A porcine mannan\u2010binding lectin\u2010A response was less evident in the pigs. Acute phase responses resembling those of the first inoculation were observed in the pigs that had not previously been inoculated and in the pigs treated with enrofloxacin. Acute phase responses were not recorded in the other three groups, where the pigs had seroconverted to\n                    <jats:italic>A pleuropneumoniae<\/jats:italic>\n                    serotype 2 following the first inoculation.\n                  <\/jats:p>","DOI":"10.1136\/vr.d2268","type":"journal-article","created":{"date-parts":[[2011,7,8]],"date-time":"2011-07-08T09:58:45Z","timestamp":1310119125000},"page":"70-70","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Effects of different antimicrobial treatments on serum acute phase responses and leucocyte counts in pigs after a primary and a secondary challenge infection with\n                    <i>Actinobacillus pleuropneumoniae<\/i>"],"prefix":"10.1002","volume":"169","author":[{"given":"M.","family":"Sj\u00f6lund","sequence":"first","affiliation":[{"name":"Department of Animal Health and Antimicrobial Strategies National Veterinary Institute 751 89 Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Fossum","sequence":"additional","affiliation":[{"name":"Section of Immunology, Department of Biomedicine and Veterinary Public Health Swedish University of Agricultural Sciences PO Box 588, Biomedical Center 751 23 Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"Mart\u00edn de la Fuente","sequence":"additional","affiliation":[{"name":"Unidad de Microbiolog\u00eda e Inmunolog\u00eda Departamento de Sanidad Animal Facultad de Veterinaria Universidad de Le\u00f3n 24007 Le\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Alava","sequence":"additional","affiliation":[{"name":"Departamento de Bioquimica Facultad de Ciencias Universidad de Zaragoza Pedro Cerbuna 12 50009 Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. R.","family":"Juul\u2010Madsen","sequence":"additional","affiliation":[{"name":"Department of Animal Health and Bioscience Faculty of Agricultural Sciences Aarhus University Blichers All\u00e9 20, Postboks 50 8830 Tjele Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Lampreave","sequence":"additional","affiliation":[{"name":"Departamento de Bioquimica Facultad de Ciencias Universidad de Zaragoza Pedro Cerbuna 12 50009 Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Wallgren","sequence":"additional","affiliation":[{"name":"Department of Animal Health and Antimicrobial Strategies National Veterinary Institute 751 89 Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,7,16]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"L1137","article-title":"Neutrophils as early immunologic effectors in hemorrhage\u2010 or endotoxemia\u2010induced acute lung injury. 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