{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T17:28:19Z","timestamp":1755797299212,"version":"3.44.0"},"reference-count":43,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"unspecified","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["World Jnl Ped Surgery"],"accepted":{"date-parts":[[2022,10,25]]},"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The estimated prevalence of esophageal atresia (EA) is 1 in 2500\u20134500 live births (LBs). Researchers have already identified risk factors, but the mechanisms are still unknown. The aim of this study is to identify EA prevalence trends and its risk factors in the S\u00e3o Paulo State (SPS) population database.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a population-based study using all EA cases identified by the Live Births Information System across 14 years (2005\u20132018) to estimate EA prevalence trends in recent years, stratified by maternal age and SPS geographical clusters. We calculated the prevalence trends, regression coefficient (\u03b2), annual percent change (APC), and 95% confidence interval (CI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found 820 EA cases among 8,536,101 LBs with a prevalence of 1.0\/10,000 LBs in SPS, Brazil. There was no significant difference in distribution by sex. Among all the cases, the majority (65%) were Caucasian; 51.8% were born at term; 43%\u2009had weight of \u22652500\u2009g; 95.4% were singleton; and 73.4% of births were by cesarean section. From 2005 to 2018, there was an increasing trend of EA prevalence (APC=6.5%) with the highest APC of 12.2%. The highest EA prevalence rate (1.7\/10,000 LB) was found in the group with maternal age of \u226535 years. No significant seasonal variation was found based on the conception month (p=0.061).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>EA had an increasing prevalence trend in SPS, Brazil, in recent years, with the highest prevalence rate in the group with maternal age of \u226535 years. No seasonality was observed. This population-based study is the first to summarize the current epidemiology of EA in SPS LB.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/wjps-2022-000455","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T22:30:16Z","timestamp":1672266616000},"page":"e000455","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Epidemiological characteristics of live births with esophageal atresia in Sao Paulo State, Brazil, from 2005 to 2018"],"prefix":"10.1136","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1988-3662","authenticated-orcid":false,"given":"Emilli Freitas","family":"Silvestri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3688-4058","authenticated-orcid":false,"given":"Eduardo Jamil Farah","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5732-591X","authenticated-orcid":false,"given":"Marcela","family":"Chiedde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3108-6615","authenticated-orcid":false,"given":"Edige Felipe Sousa","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8746-4363","authenticated-orcid":false,"given":"Mauricio Giusti","family":"Calderon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,12,28]]},"reference":[{"key":"2025081809553404000_6.1.e000455.1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00383-011-3014-1","article-title":"Aspects of esophageal atresia in a population-based setting: incidence, mortality, and cancer risk","volume":"28","author":"Oddsberg","year":"2012","journal-title":"Pediatr Surg Int"},{"key":"2025081809553404000_6.1.e000455.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2004.07.008"},{"key":"2025081809553404000_6.1.e000455.3","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-1"},{"key":"2025081809553404000_6.1.e000455.4","article-title":"Esophageal atresia and tracheoesophageal fistula","volume":"59","author":"Clark","year":"1999","journal-title":"Am Fam Physician"},{"key":"2025081809553404000_6.1.e000455.5","first-page":"70","article-title":"Esophageal Atresia-case report","volume":"39-3","author":"Romagna","year":"2010","journal-title":"Arquivos Catarinenses de Medicina"},{"key":"2025081809553404000_6.1.e000455.6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41572-019-0077-0","article-title":"Oesophageal atresia","volume":"16","author":"van Lennep","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"2025081809553404000_6.1.e000455.7","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1111\/ped.14311","article-title":"Esophageal atresia: associated anomalies, mortality, and morbidity in Jordan","volume":"62","author":"Badran","year":"2020","journal-title":"Pediatr Int"},{"key":"2025081809553404000_6.1.e000455.8","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420520104"},{"key":"2025081809553404000_6.1.e000455.9","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/bdra.23493","article-title":"Prevalence, characteristics, and survival of children with esophageal atresia: a 32-year population-based study including 1,417,724 consecutive newborns","volume":"106","author":"Cassina","year":"2016","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"2025081809553404000_6.1.e000455.10","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/bdra.23553","article-title":"Prevalence and descriptive epidemiology of esophageal atresia in the Russian Federation","volume":"106","author":"Demikova","year":"2016","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"2025081809553404000_6.1.e000455.11","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23067"},{"key":"2025081809553404000_6.1.e000455.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.03.075"},{"key":"2025081809553404000_6.1.e000455.13","doi-asserted-by":"crossref","first-page":"565","DOI":"10.5123\/S1679-49742015000300024","article-title":"Using time series analysis in epidemiological studies","volume":"24","author":"Antunes","year":"2015","journal-title":"Epidemiologia e Servi\u00e7os de Sa\u00fade"},{"key":"2025081809553404000_6.1.e000455.14","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.07.045120"},{"key":"2025081809553404000_6.1.e000455.15","unstructured":"Ministry of Health, Brasil . 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