{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:36:28Z","timestamp":1757619388415,"version":"3.44.0"},"reference-count":21,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1969,1]]},"DOI":"10.1136\/gut.10.1.16","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"16-18","source":"Crossref","is-referenced-by-count":8,"title":["Cell turnover in the rat small intestinal mucosa: an appraisal of cell loss. II. Cell loss in rats with an abnormal mucosa."],"prefix":"10.1136","volume":"10","author":[{"given":"C A","family":"Loehry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D N","family":"Croft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A K","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Creamer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1969,1,1]]},"reference":[{"key":"ref_1","first-page":"781","article-title":"Uber die Regeneration der Elemente der schlauchformigen Drusen und des Epithels des Magendarmkanals","volume":"3","author":"Bizzozero, G.","year":"1888","unstructured":"Bizzozero, G. (1888). Uber die Regeneration der Elemente der schlauchformigen Drusen und des Epithels des Magendarmkanals. Anat. Anz., 3, 781-784.","journal-title":"Anat. Anz"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1182\/blood.V22.4.406.406","article-title":"Intestinal mucosa mechanisms controlling iron absorption","volume":"22","author":"Conrad, Jr, M.E.; Crosby, W.H.","year":"1963","unstructured":"Conrad, M. E., Jr, and Crosby, W. H. (1963). Intestinal mucosa mechanisms controlling iron absorption. Blood, 22, 406-415.","journal-title":"Blood"},{"key":"ref_3","first-page":"\"963","article-title":"The role of the intestine in iron kinetics","volume":"43","author":"Weintraub, L.R.; Crosby, W.H.","year":"1964","unstructured":"*, Weintraub, L. R., and Crosby, W. H. (1964). The role of the intestine in iron kinetics. J. clin. Invest., 43, 963-974. Creamer. B., Shorter, R. G., and Bamforth, J. (1961). The turnover and shedding of epithelial cells. I. The turnover in the gastrointestinal tract. Gut, 2, 110-116.","journal-title":"J. clin. Invest; The turnover and shedding of epithelial cells. I. The turnover in the gastrointestinal tract"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1042\/bj0950612","article-title":"The estimation of deoxyribonucleic acid in the presence of sialic acid: application to analysis of human gastric washings","volume":"95","author":"Croft, D.N.; Lubran, M.","year":"1965","unstructured":"Croft, D. N., and Lubran, M. (1965). The estimation of deoxyribonucleic acid in the presence of sialic acid: application to analysis of human gastric washings. Biochem. J., 95, 612-620.","journal-title":"Biochem. J"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1136\/gut.7.4.333","article-title":"Cell loss from human gastric mucosa measured by the estimation of deoxyribonucleic acid (DNA) in gastric washings","volume":"7","year":"1966","unstructured":"Croft, D. N., and Lubran, M., Pollock, D. 3., and Coghill, N. F. (1966). Cell loss from human gastric mucosa measured by the estimation of deoxyribonucleic acid (DNA) in gastric washings. Gut, 7, 333-343.","journal-title":"Gut"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1172\/JCI102335","article-title":"Plasma and red cell iron turnover in normal subjects and inpatients having various hematopoietic disorders","volume":"29","author":"Huff, R.L.; Hennessy, T.G.; Austin, R.E.; Garcia, J.F.; Roberts, B.M.; Lawrence, J.H.","year":"1950","unstructured":"Huff, R. L., Hennessy, T. G., Austin, R. E., Garcia, J. F., Roberts, B. M., and Lawrence, J. H. (1950). Plasma and red cell iron turnover in normal subjects and inpatients having various hematopoietic disorders. J. clin. Invest., 29, 1041-1052.","journal-title":"J. clin. Invest"},{"key":"ref_7","first-page":"405","article-title":"The three dimensional structure of the human small intestinal mucosa in health and disease","volume":"46","author":"Loehry, C.A.; Creamer, B.","year":"1968","unstructured":"Loehry, C. A., and Creamer, B. (1968). The three dimensional structure of the human small intestinal mucosa in health and disease. Gut, MacDonald, W. C., Trier, J. S., and Everett, N. B. (1964). Cell proliferation and migration in the stomach, duodenum, and rectum of man. radioautographic studies. Gastroenterology, 46, 405-417.","journal-title":"Gastroenterology; Cell proliferation and migration in the stomach, duodenum, and rectum of man. radioautographic studies"},{"key":"ref_8","article-title":"Ueber die Entwicklung der dickdarmschleimhaut","author":"Patzelt, V.","year":"1882","unstructured":"Patzelt, V. (1882). Ueber die Entwicklung der dickdarmschleimhaut."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/0014-4827(59)90063-1","article-title":"Cell population kinetics in the intestinal epithelium of the mouse","volume":"17","author":"Quastler, H.; Sherman, F.G.","year":"1959","unstructured":"Quastler, H., and Sherman, F. G. (1959). Cell population kinetics in the intestinal epithelium of the mouse. Exp. Cell Res., 17, 420-438.","journal-title":"Exp. Cell Res"},{"key":"ref_10","article-title":"Beitrage zur Histologie menschlicher Organe","author":"Schaffer, J.","year":"1891","unstructured":"Schaffer, J. (1891). Beitrage zur Histologie menschlicher Organe."},{"key":"ref_11","first-page":"760","article-title":"Cell kinetics in the jejunum and rectum of man","volume":"2","author":"Shorter, R.G.; Moertel, C.G.; Titus, J.L.; Reitemeier, R.J.","year":"1964","unstructured":"Shorter, R. G., Moertel, C. G., Titus, J. L., and Reitemeier, R. J. (1964). Cell kinetics in the jejunum and rectum of man. Amer. J. dig. Dis., 2, 760-763.","journal-title":"Amer. J. dig. Dis"},{"key":"ref_12","article-title":"The DNA experiments demonstrate a considerably increased rate of cell loss in the 'flattened' small intestinal mucosa of rats infested with the nematode Nippostrongylus brasiliensis, and support the findings of Symons","volume-title":"that there is a state of increased cell turnover in this condition","year":"1965","unstructured":"The DNA experiments demonstrate a considerably increased rate of cell loss in the 'flattened' small intestinal mucosa of rats infested with the nematode Nippostrongylus brasiliensis, and support the findings of Symons (1965) that there is a state of increased cell turnover in this condition."},{"key":"ref_13","article-title":"These experiments demonstrate how measurements of cell loss may be employed in studying the dynamic state of the small intestinal mucosa. The DNA technique has been used in human studies","volume-title":"1968) and these have suggested an increased turnover state in patients with coeliac disease (Croft, Loehry, and Creamer, 1968). The increased iron loss in the experimental rats with an abnormal mucosa makes it of interest to speculate on how much of the deficiency states in coeliac disease may result, not so much from a failure of absorption, but as a result of increased loss","author":"Croft, Loehry; Taylor; Cole","unstructured":"These experiments demonstrate how measurements of cell loss may be employed in studying the dynamic state of the small intestinal mucosa. The DNA technique has been used in human studies (Croft, Loehry, Taylor, and Cole, 1968) and these have suggested an increased turnover state in patients with coeliac disease (Croft, Loehry, and Creamer, 1968). The increased iron loss in the experimental rats with an abnormal mucosa makes it of interest to speculate on how much of the deficiency states in coeliac disease may result, not so much from a failure of absorption, but as a result of increased loss."},{"key":"ref_14","first-page":"70","author":"Croft, D.N.; Loehry, C.A.; Taylor, J.F.N.; Cole, J.","year":"1968","unstructured":"Croft, D. N., Loehry, C. A., Taylor, J. F. N., and Cole, J. (1968). Lancet, 70-73.","journal-title":"Lancet"},{"key":"ref_15","first-page":"68","volume":"Ibid.,","author":"Creamer, B.","year":"1968","unstructured":",-, and Creamer, B. (1968). Ibid., 68-70."},{"key":"ref_16","article-title":"Pathology of infestation of the rat","author":"Symons, L.E.A.","year":"1960","unstructured":"Symons, L. E. A. (1960a). Pathology of infestation of the rat with N."},{"key":"ref_17","first-page":"\"180","article-title":"The absorption of glucose and histidine","volume":"13","author":"b). IV","year":"1962","unstructured":"(1960b). IV. The absorption of glucose and histidine. Ibid., 13, 180-186. -, and Fairbairn, D. (1962). Pathology, absorption, transport, and activity of digestive enzymes in rat jejunum parasitised by the nematode Nippostrongylus brasiliensis. Fed. Proc., 21, 913-918. -, - (1963). Biochemical pathology of the rat jejunum parasitised by the nematode Nippostrongylus brasiliensis. J. exp. Parasit., 13, 284-304.","journal-title":"Ibid; Pathology, absorption, transport, and activity of digestive enzymes in rat jejunum parasitised by the nematode Nippostrongylus brasiliensis"},{"key":"ref_18","first-page":"\"180","article-title":"The absorption of glucose and histidine","volume":"13","author":"b). IV","year":"1960","unstructured":"(1960b). IV. The absorption of glucose and histidine. Ibid., 13, 180-186. -, and Fairbairn, D. (1960b). IV. The absorption of glucose and histidine. Ibid., 13, 180-186.","journal-title":"Ibid; IV. The absorption of glucose and histidine"},{"key":"ref_19","first-page":"\"180","article-title":"The absorption of glucose and histidine","volume":"13","author":"b). IV","year":"1960","unstructured":"(1960b). IV. The absorption of glucose and histidine. Ibid., 13, 180-186. -, and Fairbairn, D., and Fairbairn, D. (1960b). IV. The absorption of glucose and histidine. Ibid., 13, 180-186.","journal-title":"Ibid; IV. The absorption of glucose and histidine"},{"key":"ref_20","first-page":"\"180","article-title":"The absorption of glucose and histidine","volume":"13","author":"b). IV","year":"1960","unstructured":"(1960b). IV. The absorption of glucose and histidine. Ibid., 13, 180-186. -, and Fairbairn, D., and Fairbairn, D., and Fairbairn, D. (1960b). IV. The absorption of glucose and histidine. Ibid., 13, 180-186.","journal-title":"Ibid; IV. The absorption of glucose and histidine"},{"key":"ref_21","first-page":"\"180","article-title":"The absorption of glucose and histidine","volume":"13","author":"b). IV","year":"1960","unstructured":"(1960b). IV. The absorption of glucose and histidine. Ibid., 13, 180-186. -, and Fairbairn, D., and Fairbairn, D., and Fairbairn, D., and Fairbairn, D. (1960b). IV. The absorption of glucose and histidine. Ibid., 13, 180-186. -, and Fairbairn, D. (1965). Kinetics of the epithelial cells and morphology of villi and crypts in the jejunum of the rat infested by the nematode Nippostrongylus brasiliensis. Gastroenterology, 49, 158-168.","journal-title":"Ibid; IV. The absorption of glucose and histidine"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.10.1.16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T20:33:51Z","timestamp":1757277231000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.10.1.16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,1]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1969,1,1]]},"published-print":{"date-parts":[[1969,1]]}},"alternative-id":["10.1136\/gut.10.1.16"],"URL":"https:\/\/doi.org\/10.1136\/gut.10.1.16","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1969,1]]}}}