{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:37:22Z","timestamp":1760204242725,"version":"3.44.0"},"reference-count":16,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1974,4]]},"abstract":"<jats:p>Bacteriostatic agents are frequently recommended as alternatives to penicillin for prophylaxis of bacterial endocarditis. To test the efficacy of this group of antimicrobials, prophylaxis of experimental streptococcal endocarditis was attempted with tetracycline. The number of streptococci colonizing the aortic valves of rabbits was not affected by inhibitory levels of tetracycline, but multiplication was checked. Streptococcis urvived in vegetations for seven days despite the continuous presence of tetracycline, and multiplied when the drug was withdrawn. It is therefore suggested that bacteriostatic agents may be valueless for prophylaxis of bacterial endocarditis.<\/jats:p>","DOI":"10.1136\/jcp.27.4.261","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"261-264","source":"Crossref","is-referenced-by-count":24,"title":["Chemotherapy of experimental streptococcal endocarditis"],"prefix":"10.1136","volume":"27","author":[{"given":"Frederick S.","family":"Southwick","sequence":"first","affiliation":[]},{"given":"David T.","family":"Durack","sequence":"additional","affiliation":[]}],"member":"239","published-online":{"date-parts":[[1974,4,1]]},"reference":[{"key":"ref_1","first-page":"953","article-title":"prevention of rheumatic Fever and Bacterial Endocarditis","volume":"31","author":"American Heart Association Committee on","year":"1965","unstructured":"American Heart Association Committee on prevention of rheumatic Fever and Bacterial Endocarditis (1965). Prevention of rheumatic fever and bacterial endocarditis. Circulation, 31, 953-954.","journal-title":"Circulation; Prevention of rheumatic fever and bacterial endocarditis"},{"key":"ref_2","first-page":"50","article-title":"A concept of the pathogenesis of endocarditis based on a study of transitional lesions","volume":"30","author":"Angrist, A.A.","year":"1950","unstructured":"Angrist, A. A. (1950). A concept of the pathogenesis of endocarditis based on a study of transitional lesions. Proc. N. Y. St. Ass. Publ. Hlth Labs., 30, 50.","journal-title":"Proc. N. Y. St. Ass. Publ. Hlth Labs"},{"key":"ref_3","first-page":"1106","article-title":"Bacterial endocarditis. Chemotherapy","volume-title":"CecilLeob Textbook of Medicine","author":"Beeson, P.B.","year":"1971","unstructured":"Beeson, P. B. (1971). Bacterial endocarditis. Chemotherapy. In CecilLeob Textbook of Medicine, edited by P. B. Becson and W. 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Production and progress of the disease in rabbits","volume":"54","author":"Durack, D.T.; Beeson, P.B.; Petersdorf, R.G.","year":"1973","unstructured":"Durack, D. T., Beeson, P. B., and Petersdorf, R. G. (1973). Experimental bacterial endocarditis III. Production and progress of the disease in rabbits. Brit. J. exp. Path., 54, 142-151.","journal-title":"Brit. J. exp. Path"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1172\/JCI107220","article-title":"Chemotherapy of experimental streptococcal endocarditis. I. Comparison of commonly recommended prophylactic regimens","volume":"52","author":"Durack, D.T.; G, Petersdorf R.","year":"1973","unstructured":"Durack, D. T., and Petersdorf R. G. (1973). Chemotherapy of experimental streptococcal endocarditis. I. Comparison of commonly recommended prophylactic regimens. J. clin. Invest, 52, 592-598.","journal-title":"J. clin. Invest"},{"key":"ref_8","first-page":"50","article-title":"Experimental bacterial endocarditis. II. Survival of bacteria in endocardial vegetations","volume":"53","author":"Durack, D.T.; Beeson, P.B.","year":"1972","unstructured":"Durack, D. T., and Beeson, P. B. (1972). Experimental bacterial endocarditis. II. Survival of bacteria in endocardial vegetations. Brit. J. exp. Path., 53, 50-53.","journal-title":"Brit. J. exp. Path"},{"key":"ref_9","first-page":"1414","article-title":"Diseases of the Heart","author":"Friedberg, C.K.","year":"1966","unstructured":"Friedberg, C. K. (1966a). Diseases of the Heart, p. 1414."},{"key":"ref_10","first-page":"1411","article-title":"Diseases of the Heart","author":"Friedberg, C.K.","year":"1966","unstructured":"Friedberg, C. K. (1966b). Diseases of the Heart, p. 1411."},{"key":"ref_11","first-page":"247","article-title":"Heart valve irregularities in relation to subacute bacterial endocarditis","volume":"14","author":"Grant, R.T.; Wood, J.E.; Jones, T.D.","year":"1928","unstructured":"Grant, R. T., Wood, J. E., and Jones, T. D. (1928). Heart valve irregularities in relation to subacute bacterial endocarditis. Heart, 14, 247-261.","journal-title":"Heart"},{"key":"ref_12","first-page":"769","article-title":"The role played by rheumatic fever in the implantation of bacterial endocarditis","volume":"13","author":"Gross, L.; Fried, B.M.","year":"1937","unstructured":"Gross, L., and Fried, B. M. (1937). The role played by rheumatic fever in the implantation of bacterial endocarditis. Amer. J. Path., 13, 769-798.","journal-title":"Amer. J. 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(1966). An effective antibiotic cover for the prevention of endocarditis following dental and other post-operative bacteraemias. J. clin. Path., 19, 561-566.","journal-title":"J. Biol. Med; An effective antibiotic cover for the prevention of endocarditis following dental and other post-operative bacteraemias"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1001\/archinte.1953.00240220033007","article-title":"Chlortetracycline (Aureomycin) in prevention of bacteremia following oral surgery","volume":"92","author":"Roth, O.; Montano, G.M.; Piccolo, J.A.; Cavallaro, A.L.; Sharkey, D.C.; Celentano, R.","year":"1953","unstructured":"Roth, O., Montano, G. M., Piccolo, J. A., Cavallaro, A. L., Sharkey, D. C., and Celentano, R. (1953). Chlortetracycline (Aureomycin) in prevention of bacteremia following oral surgery. Arch. intern. Med., 92, 485-489.","journal-title":"Arch. intern. 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