{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:11:40Z","timestamp":1760955100037,"version":"3.44.0"},"reference-count":28,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Path"],"published-print":{"date-parts":[[1998,4]]},"DOI":"10.1136\/mp.51.2.85","type":"journal-article","created":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T19:10:34Z","timestamp":1230750634000},"page":"85-89","source":"Crossref","is-referenced-by-count":7,"title":["Pseudo-rearrangement of the MLL gene at chromosome 11q23: a cautionary note on genotype analysis of leukaemia patients."],"prefix":"10.1136","volume":"51","author":[{"given":"M","family":"Stanulla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H J","family":"Sch\u00fcnemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Thandla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M L","family":"Brecher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P D","family":"Aplan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1998,4,1]]},"reference":[{"key":"ref_1","first-page":"10735","article-title":"Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated","volume-title":"with human leukemias. Proc Natl Acad Sci","volume":"88","author":"der Poel S, Ziemin-van; NR, McCabe; HJ, Gill","year":"1991","unstructured":"Ziemin-van der Poel S, McCabe NR, Gill HJ, et al. Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Proc Natl Acad Sci USA 1991;88:10735\u20139."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/ng1092-113","article-title":"A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukemias","volume":"2","author":"Djabali, M.; Selleri, L.; Parry, P.","year":"1992","unstructured":"Djabali M, Selleri L, Parry P, et al. A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukemias. Nat Genet 1992;2:113\u201318.","journal-title":"Nat Genet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0092-8674(92)90603-A","article-title":"The t(4; 11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene","volume":"71","author":"Gu, Y.; Nakamura, T.; Alder, H.","year":"1992","unstructured":"Gu Y, Nakamura T, Alder H, et al. The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell 1992;71:701\u20138.","journal-title":"Cell"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/0092-8674(92)90602-9","article-title":"Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias","volume":"71","author":"Tkachuk, D.; Kohler, S.; Cleary, M.","year":"1992","unstructured":"Tkachuk D, Kohler S, Cleary M. Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell 1992;71:691\u2013700.","journal-title":"Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1056\/NEJM199309233291302","article-title":"Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations","volume":"329","author":"Thirman, M.J.; Gill, H.J.; Burnett, R.C.","year":"1993","unstructured":"Thirman MJ, Gill HJ, Burnett RC, et al. Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations. N Engl J Med 1993;329:909\u201314.","journal-title":"N Engl J Med"},{"key":"ref_6","first-page":"74","article-title":"11q23 rearrangements in acute leukemia","volume":"10","author":"Rubnitz, J.E.; Behm, F.G.; Downing, JR","year":"1996","unstructured":"Rubnitz JE, Behm FG, Downing JR. 11q23 rearrangements in acute leukemia. Leukemia 1996;10:74\u201382.","journal-title":"Leukemia"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3109\/10428199709114159","article-title":"Molecular analysis of infant acute leukemia","volume":"25","author":"Hilden, J.M.; Frestesdt, J.L.; Kersey, J.H.","year":"1997","unstructured":"Hilden JM, Frestesdt JL, Kersey JH. Molecular analysis of infant acute leukemia. Leuk Lymphoma 1997;25:191\u20139.","journal-title":"Leuk Lymphoma"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.1182\/blood.V82.12.3705.3705","article-title":"Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA topoisomerase II","volume":"82","author":"Gill-Super, H.J.; McCabe, N.R.; Thirman, M.J.","year":"1993","unstructured":"Gill-Super HJ, McCabe NR, Thirman MJ, et al. Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA topoisomerase II. Blood 1993;82:3705\u201311.","journal-title":"Blood"},{"key":"ref_9","first-page":"226","article-title":"Human trithorax gene rearrangements in therapy-related acute leukemia after etoposide treatment","volume":"8","author":"Bower, M.; Parry, P.; Gibbons, B.","year":"1994","unstructured":"Bower M, Parry P, Gibbons B, et al. Human trithorax gene rearrangements in therapy-related acute leukemia after etoposide treatment. Leukemia 1994;8:226\u20139.","journal-title":"Leukemia"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1056\/NEJM199309233291311","article-title":"A promiscuous oncogene in acute leukemia","volume":"329","author":"Cleary, M.L.","year":"1993","unstructured":"Cleary ML. A promiscuous oncogene in acute leukemia. N Engl J Med 1993;329:958\u20139.","journal-title":"N Engl J Med"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1200\/JCO.1996.14.2.680","article-title":"Uniform criteria for childhood acute lymphoblastic leukemia risk classification","volume":"14","author":"Smith, M.; Bleyer, A.; Crist, W.","year":"1996","unstructured":"Smith M, Bleyer A, Crist W, et al. Uniform criteria for childhood acute lymphoblastic leukemia risk classification. J Clin Oncol 1996;14:680\u20131.","journal-title":"J Clin Oncol"},{"key":"ref_12","first-page":"32","article-title":"Molecular biology of acute myeloid leukemia","volume":"24","author":"Caligiuri, M.A.; Strout, M.P.; Gilliland, D.G.","year":"1997","unstructured":"Caligiuri MA, Strout MP, Gilliland DG. Molecular biology of acute myeloid leukemia. Semin Oncol 1997;24:32\u201344.","journal-title":"Semin Oncol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1182\/blood.V81.9.2386.2386","article-title":"Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and a poor outcome","volume":"81","author":"Chen, C.-S.; Sorensen, P.H.B.; Domer, P.H.","year":"1993","unstructured":"Chen C-S, Sorensen PHB, Domer PH, et al. Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and a poor outcome. Blood 1993;81:2386\u201393.","journal-title":"Blood"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1200\/JCO.1994.12.5.909","article-title":"11q23\/MLL rearrangement confers a poor prognosis in infants with acute lymphoblastic leukemia","volume":"12","author":"Pui, C.-H.; Behm, F.G.; Downing, JR","year":"1994","unstructured":"Pui C-H, Behm FG, Downing JR, et al. 11q23\/MLL rearrangement confers a poor prognosis in infants with acute lymphoblastic leukemia. J Clin Oncol 1994;12:909\u2013 15.","journal-title":"J Clin Oncol"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1172\/JCI116978","article-title":"Molecular rearrangements of the MLL gene are present in most cases of infant acute myeloid leukemia and are strongly correlated with monocytic or myelomonocytic phenotypes","volume":"93","author":"Sorensen, P.H.B.; Chen, C.-S.; Smith, F.O.","year":"1994","unstructured":"Sorensen PHB, Chen C-S, Smith FO, et al. Molecular rearrangements of the MLL gene are present in most cases of infant acute myeloid leukemia and are strongly correlated with monocytic or myelomonocytic phenotypes. J Clin Invest 1994;93:429\u201337.","journal-title":"J Clin Invest"},{"key":"ref_16","first-page":"1303","article-title":"Frequency and clinical significance of MLL gene rearrangements in infant acute leukemia","volume":"10","author":"Taki, T.; Ida, K.; Bessho, F.","year":"1996","unstructured":"Taki T, Ida K, Bessho F, et al. Frequency and clinical significance of MLL gene rearrangements in infant acute leukemia. Leukemia 1996;10:1303\u20137.","journal-title":"Leukemia"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1182\/blood.V87.7.2649.bloodjournal8772649","article-title":"Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors","volume":"87","author":"Aplan, P.D.; Chervinsky, D.S.; Stanulla, M.","year":"1996","unstructured":"Aplan PD, Chervinsky DS, Stanulla M, et al. Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors. Blood 1996;87: 2649\u201358.","journal-title":"Blood"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.1128\/MCB.17.7.4070","article-title":"DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis","volume":"17","author":"Stanulla, M.; Wang, J.; Chervinsky, D.S.","year":"1997","unstructured":"Stanulla M, Wang J, Chervinsky DS, et al. DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis. Mol Cell Biol 1997;17:4070\u20139.","journal-title":"Mol Cell Biol"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0074-7696(08)62312-8","article-title":"Cell death: the significance of apoptosis","volume":"68","author":"Wyllie, A.H.; Kerr, J.F.R.; Currie, A.R.","year":"1980","unstructured":"Wyllie AH, Kerr JFR, Currie AR. Cell death: the significance of apoptosis. Int Rev Cytol 1980;68:251\u2013306.","journal-title":"Int Rev Cytol"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/0092-8674(94)90518-5","article-title":"Apoptosis in cancer therapy: crossing the threshold","volume":"78","author":"Fisher, D.E.","year":"1994","unstructured":"Fisher DE. Apoptosis in cancer therapy: crossing the threshold. Cell 1994;78:539\u201342.","journal-title":"Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/0006-291X(74)90355-6","article-title":"Identification of a nuclear protein matrix","volume":"60","author":"Berezney, R.; CoVey, D.S.","year":"1974","unstructured":"Berezney R, CoVey DS. Identification of a nuclear protein matrix. Biochem Biophys Res Commun 1974;60:1410\u201319.","journal-title":"Biochem Biophys Res Commun"},{"key":"ref_22","first-page":"23","article-title":"Organization of the higher-order chromatin loop: specific DNA attachment sites on nuclear scaVold","volume":"39","author":"Mircovich, J.; Mirault, M.E.; Laemmli, U.K.","year":"1984","unstructured":"Mircovich J, Mirault ME, Laemmli UK. Organization of the higher-order chromatin loop: specific DNA attachment sites on nuclear scaVold. Cell 1984;39:23\u201332.","journal-title":"Cell"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1002\/j.1460-2075.1993.tb06042.x","article-title":"Apoptotic death in epithelial cells: cleavage of DNA to 300 and\/or 50 kb fragments prior to or in absence of internucleosomal fragmentation","volume":"12","author":"Oberhammer, F.A.; Wilson, J.W.; Dive, C.","year":"1993","unstructured":"Oberhammer FA, Wilson JW, Dive C, et al. Apoptotic death in epithelial cells: cleavage of DNA to 300 and\/or 50 kb fragments prior to or in absence of internucleosomal fragmentation. EMBO J 1993;12:3679\u201384.","journal-title":"EMBO J"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0962-8924(00)88932-1","article-title":"The role of DNA fragmentation in apoptosis","volume":"5","author":"Bortner, C.D.; Oldenburg, N.B.E.; Cidlowski, J.A.","year":"1995","unstructured":"Bortner CD, Oldenburg NBE, Cidlowski JA. The role of DNA fragmentation in apoptosis. Trends Cell Biol 1995;5: 21\u20136.","journal-title":"Trends Cell Biol"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1182\/blood.V87.5.1912.1912","article-title":"Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute myeloid leukemia and in treatment-related acute myeloid leukemia: correlation with scaVold attachment regions and topoisomerase II binding sites","volume":"87","author":"Strissel-Broeker, P.L.; Gill-Super, H.; Thirman, M.J.","year":"1996","unstructured":"Strissel-Broeker PL, Gill-Super H, Thirman MJ, et al. Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute myeloid leukemia and in treatment-related acute myeloid leukemia: correlation with scaVold attachment regions and topoisomerase II binding sites. Blood 1996;87:1912\u201322.","journal-title":"Blood"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1182\/blood.V81.9.2237.2237","article-title":"Current status of cytogenetic research in childhood acute lymphoblastic leukemia","volume":"81","author":"Raimondi, S.C.","year":"1993","unstructured":"Raimondi SC. Current status of cytogenetic research in childhood acute lymphoblastic leukemia. Blood 1993;81: 2237\u201351.","journal-title":"Blood"},{"key":"ref_27","first-page":"17","article-title":"Clinical significance of cytogenetics in acute myeloid leukemia","volume":"24","author":"la Chapelle A","year":"1997","unstructured":"Mr\u00f3zek K, Heinonen K, de la Chapelle A, et al. Clinical significance of cytogenetics in acute myeloid leukemia. Semin Oncol 1997;24:17\u201331.","journal-title":"Semin Oncol"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1182\/blood.V89.6.2224","article-title":"MLL cleavage occurs in approximately 5% of de novo acute myeloid leukemia, including in patients analyzed before treatment induction","volume":"89","author":"Macintyre, E.; Bourquelot, P.; Leboeuf, D.","year":"1997","unstructured":"Macintyre E, Bourquelot P, Leboeuf D, et al. MLL cleavage occurs in approximately 5% of de novo acute myeloid leukemia, including in patients analyzed before treatment induction. Blood 1997;89:2224\u20136.","journal-title":"Blood"}],"container-title":["Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/mp.51.2.85","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T17:16:06Z","timestamp":1756055766000},"score":1,"resource":{"primary":{"URL":"https:\/\/mp.bmj.com\/lookup\/doi\/10.1136\/mp.51.2.85"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,4]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1998,4,1]]},"published-print":{"date-parts":[[1998,4]]}},"alternative-id":["10.1136\/mp.51.2.85"],"URL":"https:\/\/doi.org\/10.1136\/mp.51.2.85","relation":{},"ISSN":["1366-8714","1472-4154"],"issn-type":[{"type":"print","value":"1366-8714"},{"type":"electronic","value":"1472-4154"}],"subject":[],"published":{"date-parts":[[1998,4]]}}}