{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:27:17Z","timestamp":1788431237273,"version":"build-2803163510"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"608","license":[{"start":{"date-parts":[[1976,6,1]],"date-time":"1976-06-01T00:00:00Z","timestamp":202435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1976,6,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The respective roles of cell-mediated immunity and humoral immunity in host defence were investigated in mice infected with influenza A\/PR8 virus. Transferred immune spleen cells were shown to provide full protection only when they were actually secreting antibody. Serum antibody transferred in \u2018physiological\u2019 amounts was found to be protective in immunologically intact or in immunosuppressed animals. The specificity of the transferred antibody was shown to be critical, since antibody to internal components of the virus was inefficient while antibody to haemagglutinin, especially that to the strain-specific determinants of the haemagglutinin molecule, was highly efficient.<\/jats:p>","DOI":"10.1136\/pgmj.52.608.332","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:31:39Z","timestamp":1230582699000},"page":"332-337","source":"Crossref","is-referenced-by-count":24,"title":["The role of humoral immunity in host defence against influenza A infection in mice"],"prefix":"10.1093","volume":"52","author":[{"given":"J L","family":"Virelizier","sequence":"first","affiliation":[{"name":"Cell Pathology Division, Clinical Research Centre, Harrow and Division of Virology, National Institute for Medical Research , Mill Hill, London NW7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J S","family":"Oxford","sequence":"additional","affiliation":[{"name":"Cell Pathology Division, Clinical Research Centre, Harrow and Division of Virology, National Institute for Medical Research , Mill Hill, London NW7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G C","family":"Schild","sequence":"additional","affiliation":[{"name":"Cell Pathology Division, Clinical Research Centre, Harrow and Division of Virology, National Institute for Medical Research , Mill Hill, London NW7"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1976,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1128\/IAI.11.5.886-889.1975","article-title":"Effect of cyclophosphamide on infections in mice caused by virulent and avirulent strains of influenza virus","volume":"11","author":"HURD, J.; HEATH, R.B.","year":"1975","unstructured":"HURD, J. & HEATH, R.B. (1975) Effect of cyclophosphamide on infections in mice caused by virulent and avirulent strains of influenza virus. Infection and Immunity, 11, 886.","journal-title":"Infection and Immunity"},{"key":"ref_2","first-page":"51","article-title":"Cross immune reactions between A (H1Nj) and A (H2N2) influenza viruses","volume":"16","author":"KURIMURA, T.; HIRANO, A.; OKUNO, Y.","year":"1973","unstructured":"KURIMURA, T., HIRANO, A. & OKUNO, Y. (1973) Cross immune reactions between A (H1Nj) and A (H2N2) influenza viruses. Biken's Journal, 16, 51.","journal-title":"Biken's Journal"},{"key":"ref_3","first-page":"109","article-title":"Isolation of haemagglutinin subunits from influenza viruses","volume":"9","author":"LAVER, W.R.","year":"1964","unstructured":"LAVER, W.R. (1964) Isolation of haemagglutinin subunits from influenza viruses. 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(D), 263, 1913."}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/52\/608\/332\/50184749\/postgradmedj-52-332.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/52\/608\/332\/50184749\/postgradmedj-52-332.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T06:21:48Z","timestamp":1684822908000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/52\/608\/332\/7037886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,6,1]]},"references-count":21,"journal-issue":{"issue":"608","published-online":{"date-parts":[[1976,6,1]]},"published-print":{"date-parts":[[1976,6,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.52.608.332","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1976,6]]},"published":{"date-parts":[[1976,6,1]]}}}