{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T14:21:36Z","timestamp":1776435696082,"version":"3.51.2"},"reference-count":39,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1136\/annrheumdis-2013-204838","type":"journal-article","created":{"date-parts":[[2014,1,25]],"date-time":"2014-01-25T02:52:22Z","timestamp":1390618342000},"page":"1011-1018","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":658,"title":["Morbidity and mortality in the antiphospholipid syndrome during a 10-year period: a multicentre prospective study of 1000 patients"],"prefix":"10.1016","volume":"74","author":[{"given":"R","family":"Cervera","sequence":"first","affiliation":[]},{"given":"R","family":"Serrano","sequence":"additional","affiliation":[]},{"given":"G J","family":"Pons-Estel","sequence":"additional","affiliation":[]},{"given":"L","family":"Ceberio-Hualde","sequence":"additional","affiliation":[]},{"given":"Y","family":"Shoenfeld","sequence":"additional","affiliation":[]},{"given":"E","family":"de Ram\u00f3n","sequence":"additional","affiliation":[]},{"given":"V","family":"Buonaiuto","sequence":"additional","affiliation":[]},{"given":"S","family":"Jacobsen","sequence":"additional","affiliation":[]},{"given":"M M","family":"Zeher","sequence":"additional","affiliation":[]},{"given":"T","family":"Tarr","sequence":"additional","affiliation":[]},{"given":"A","family":"Tincani","sequence":"additional","affiliation":[]},{"given":"M","family":"Taglietti","sequence":"additional","affiliation":[]},{"given":"G","family":"Theodossiades","sequence":"additional","affiliation":[]},{"given":"E","family":"Nomikou","sequence":"additional","affiliation":[]},{"given":"M","family":"Galeazzi","sequence":"additional","affiliation":[]},{"given":"F","family":"Bellisai","sequence":"additional","affiliation":[]},{"given":"P L","family":"Meroni","sequence":"additional","affiliation":[]},{"given":"R H W M","family":"Derksen","sequence":"additional","affiliation":[]},{"given":"P G D","family":"de Groot","sequence":"additional","affiliation":[]},{"given":"M","family":"Baleva","sequence":"additional","affiliation":[]},{"given":"M","family":"Mosca","sequence":"additional","affiliation":[]},{"given":"S","family":"Bombardieri","sequence":"additional","affiliation":[]},{"given":"F","family":"Houssiau","sequence":"additional","affiliation":[]},{"given":"J-C","family":"Gris","sequence":"additional","affiliation":[]},{"given":"I","family":"Qu\u00e9r\u00e9","sequence":"additional","affiliation":[]},{"given":"E","family":"Hachulla","sequence":"additional","affiliation":[]},{"given":"C","family":"Vasconcelos","sequence":"additional","affiliation":[]},{"given":"A","family":"Fern\u00e1ndez-Nebro","sequence":"additional","affiliation":[]},{"given":"M","family":"Haro","sequence":"additional","affiliation":[]},{"given":"Z","family":"Amoura","sequence":"additional","affiliation":[]},{"given":"M","family":"Miyara","sequence":"additional","affiliation":[]},{"given":"M","family":"Tektonidou","sequence":"additional","affiliation":[]},{"given":"G","family":"Espinosa","sequence":"additional","affiliation":[]},{"given":"M L","family":"Bertolaccini","sequence":"additional","affiliation":[]},{"given":"M A","family":"Khamashta","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1136\/annrheumdis-2013-204838_bib1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1056\/NEJMra1112830","article-title":"The pathogenesis of the antiphospholipid syndrome","volume":"368","author":"Giannakopoulos","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1136\/annrheumdis-2013-204838_bib2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","article-title":"International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)","volume":"4","author":"Miyakis","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1136\/annrheumdis-2013-204838_bib3","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1002\/art.10187","article-title":"Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients","volume":"46","author":"Cervera","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1136\/annrheumdis-2013-204838_bib4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3109\/08916939108997126","article-title":"The \u2018primary\u2019 antiphospholipid syndrome: antiphospholipid antibody pattern and clinical features of a series of 23 patients","volume":"9","author":"Font","year":"1991","journal-title":"Autoimmunity"},{"key":"10.1136\/annrheumdis-2013-204838_bib5","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jaut.2009.02.008","article-title":"Catastrophic antiphospholipid syndrome (CAPS): descriptive analysis of a series of 280 patients from the \u2018CAPS Registry\u2019","volume":"32","author":"Cervera","year":"2009","journal-title":"J Autoimmun"},{"key":"10.1136\/annrheumdis-2013-204838_bib6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0002-9343(94)90108-2","article-title":"Comparison of the primary and secondary antiphospholipid syndrome: a European Multicenter Study of 114 patients","volume":"96","author":"Vianna","year":"1994","journal-title":"Am J Med"},{"key":"10.1136\/annrheumdis-2013-204838_bib7","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.3899\/jrheum.081194","article-title":"Determinants of risk for venous and arterial thrombosis in primary antiphospholipid syndrome and in antiphospholipid syndrome with systemic lupus erythematosus","volume":"36","author":"Danowski","year":"2009","journal-title":"J Rheumatol"},{"key":"10.1136\/annrheumdis-2013-204838_bib8","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/01.md.0000172074.53583.ea","article-title":"Long-term follow-up in 128 patients with primary antiphospholipid syndrome: do they develop lupus?","volume":"84","author":"Gomez-Puerta","year":"2005","journal-title":"Medicine (Baltimore)"},{"key":"10.1136\/annrheumdis-2013-204838_bib9","first-page":"2817","article-title":"Primary antiphospholipid syndrome: functional outcome after 10 years","volume":"27","author":"Erkan","year":"2000","journal-title":"J Rheumatol"},{"key":"10.1136\/annrheumdis-2013-204838_bib10","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1177\/0961203312446974","article-title":"Antiphospholipid syndrome in northwest Italy (APS Piedmont Cohort): demographic features, risk factors, clinical and laboratory profile","volume":"21","author":"Bertero","year":"2012","journal-title":"Lupus"},{"key":"10.1136\/annrheumdis-2013-204838_bib11","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1136\/ard.2008.093179","article-title":"Morbidity and mortality in the antiphospholipid syndrome during a 5-year period: a multicentre prospective study of 1000 patients","volume":"68","author":"Cervera","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/annrheumdis-2013-204838_bib12","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1177\/0961203309106832","article-title":"The Euro-Phospholipid project: epidemiology of the antiphospholipid syndrome in Europe","volume":"18","author":"Cervera","year":"2009","journal-title":"Lupus"},{"key":"10.1136\/annrheumdis-2013-204838_bib13","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/art.1780251101","article-title":"The 1982 revised criteria for the classification of systemic lupus erythematosus","volume":"25","author":"Tan","year":"1982","journal-title":"Arthritis Rheum"},{"key":"10.1136\/annrheumdis-2013-204838_bib14","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"key":"10.1136\/annrheumdis-2013-204838_bib15","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1056\/NEJM197502132920706","article-title":"Polymyositis and dermatomyositis (first of two parts)","volume":"292","author":"Bohan","year":"1975","journal-title":"N Engl J Med"},{"key":"10.1136\/annrheumdis-2013-204838_bib16","first-page":"581","article-title":"Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee","volume":"23","year":"1980","journal-title":"Arthritis Rheum"},{"key":"10.1136\/annrheumdis-2013-204838_bib17","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/art.1780360309","article-title":"Preliminary criteria for the classification of Sjogren\u2019s syndrome. Results of a prospective concerted action supported by the European Community","volume":"36","author":"Vitali","year":"1993","journal-title":"Arthritis Rheum"},{"key":"10.1136\/annrheumdis-2013-204838_bib18","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/art.1780330802","article-title":"The American College of Rheumatology 1990 criteria for the classification of vasculitis. Introduction","volume":"33","author":"Hunder","year":"1990","journal-title":"Arthritis Rheum"},{"key":"10.1136\/annrheumdis-2013-204838_bib19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1136\/ard.51.2.147","article-title":"The antiphospholipid syndrome: a syndrome in evolution","volume":"51","author":"Asherson","year":"1992","journal-title":"Ann Rheum Dis"},{"issue":"Suppl 7","key":"10.1136\/annrheumdis-2013-204838_bib20","first-page":"1","article-title":"Headache Classification Committee of the International Headache Society","volume":"8","year":"1988","journal-title":"Cephalalgia"},{"key":"10.1136\/annrheumdis-2013-204838_bib21","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1191\/0961203303lu394oa","article-title":"Catastrophic antiphospholipid syndrome: international consensus statement on classification criteria and treatment guidelines","volume":"12","author":"Asherson","year":"2003","journal-title":"Lupus"},{"key":"10.1136\/annrheumdis-2013-204838_bib22","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/00005792-199303000-00005","article-title":"Systemic lupus erythematosus: clinical and immunologic patterns of disease expression in a cohort of 1,000 patients. The European Working Party on Systemic Lupus Erythematosus","volume":"72","author":"Cervera","year":"1993","journal-title":"Medicine"},{"key":"10.1136\/annrheumdis-2013-204838_bib23","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1055\/s-0037-1616089","article-title":"Anticardiolipin antibody assay: a methodological analysis for a better consensus in routine determinations\u2014a cooperative project of the European Antiphospholipid Forum","volume":"86","author":"Tincani","year":"2001","journal-title":"Thromb Haemost"},{"key":"10.1136\/annrheumdis-2013-204838_bib24","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1055\/s-0038-1649901","article-title":"Criteria for the diagnosis of lupus anticoagulants: an update. On behalf of the Subcommittee on Lupus Anticoagulant\/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTH","volume":"74","author":"Brandt","year":"1995","journal-title":"Thromb Haemost"},{"key":"10.1136\/annrheumdis-2013-204838_bib25","series-title":"World health statistics","year":"2011"},{"key":"10.1136\/annrheumdis-2013-204838_bib26","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJM199504133321504","article-title":"The management of thrombosis in the antiphospholipid-antibody syndrome","volume":"332","author":"Khamashta","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1136\/annrheumdis-2013-204838_bib27","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0049-0172(99)80029-8","article-title":"Clinical study and follow-up of 100 patients with the antiphospholipid syndrome","volume":"29","author":"Munoz-Rodriguez","year":"1999","journal-title":"Semin Arthritis Rheum"},{"key":"10.1136\/annrheumdis-2013-204838_bib28","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1177\/0961203307077108","article-title":"Antiphospholipid syndrome in Latin American patients: clinical and immunologic characteristics and comparison with European patients","volume":"16","author":"Garcia-Carrasco","year":"2007","journal-title":"Lupus"},{"key":"10.1136\/annrheumdis-2013-204838_bib29","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1177\/0961203312458469","article-title":"Predominant prevalence of arterial thrombosis in Japanese patients with antiphospholipid syndrome","volume":"21","author":"Fujieda","year":"2012","journal-title":"Lupus"},{"key":"10.1136\/annrheumdis-2013-204838_bib30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/MD.0b013e31829cae47","article-title":"Prevalence of the antiphospholipid syndrome and its effect on survival in 679 Chinese patients with systemic lupus erythematosus: a cohort study","volume":"92","author":"Mok","year":"2013","journal-title":"Medicine"},{"key":"10.1136\/annrheumdis-2013-204838_bib31","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1517\/14656560902772302","article-title":"Thromboprophylaxis and obstetric management of the antiphospholipid syndrome","volume":"10","author":"Espinosa","year":"2009","journal-title":"Expert Opin Pharmacother"},{"key":"10.1136\/annrheumdis-2013-204838_bib32","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/art.20105","article-title":"Management of the obstetric antiphospholipid syndrome","volume":"50","author":"Derksen","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1136\/annrheumdis-2013-204838_bib33","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.berh.2009.04.004","article-title":"Managing lupus patients during pregnancy","volume":"23","author":"Ruiz-Irastorza","year":"2009","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1136\/annrheumdis-2013-204838_bib34","first-page":"508","article-title":"The catastrophic antiphospholipid syndrome","volume":"19","author":"Asherson","year":"1992","journal-title":"J Rheumatol"},{"key":"10.1136\/annrheumdis-2013-204838_bib35","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1002\/art.22018","article-title":"Mortality in the catastrophic antiphospholipid syndrome: causes of death and prognostic factors in a series of 250 patients","volume":"54","author":"Bucciarelli","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1136\/annrheumdis-2013-204838_bib36","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1177\/0961203309106833","article-title":"The CAPS Registry: morbidity and mortality of the catastrophic antiphospholipid syndrome","volume":"18","author":"Bucciarelli","year":"2009","journal-title":"Lupus"},{"key":"10.1136\/annrheumdis-2013-204838_bib37","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/00005792-198911000-00004","article-title":"The \u2018primary\u2019 antiphospholipid syndrome: major clinical and serological features. Medicine","volume":"68","author":"Asherson","year":"1989","journal-title":"Baltimore"},{"key":"10.1136\/annrheumdis-2013-204838_bib38","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1001\/archinte.162.10.1164","article-title":"Bleeding and recurrent thrombosis in definite antiphospholipid syndrome: analysis of a series of 66 patients treated with oral anticoagulation to a target international normalized ratio of 3.5","volume":"162","author":"Ruiz-Irastorza","year":"2002","journal-title":"Arch Intern Med"},{"key":"10.1136\/annrheumdis-2013-204838_bib39","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/01.md.0000091181.93122.55","article-title":"Morbidity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort of 1,000 patients","volume":"82","author":"Cervera","year":"2003","journal-title":"Medicine"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724026748?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724026748?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/annrheumdis-2013-204838","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T23:21:53Z","timestamp":1737242513000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724026748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S0003496724026748"],"URL":"https:\/\/doi.org\/10.1136\/annrheumdis-2013-204838","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Morbidity and mortality in the antiphospholipid syndrome during a 10-year period: a multicentre prospective study of 1000 patients","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/annrheumdis-2013-204838","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http:\/\/group.bmj.com\/group\/rights-licensing\/permissions. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}