{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T09:53:23Z","timestamp":1775210003661,"version":"3.50.1"},"reference-count":11,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2015,6,3]]},"abstract":"<jats:p>Neonatal hyponatraemia is common, and related to significant morbidity and mortality. We report a case of a preterm newborn (gestational age of 36\u2005weeks) with hyponatraemia, and with a prenatal diagnosis of cleft lip and palate, with a normal fetal karyotype. On the seventh day of life, a biochemical evaluation for jaundice and mild signs of dehydration showed hyponatraemia of 124\u2005mmol\/L. Investigation showed normal adrenal and thyroid functions, plasma hyposmolality (258\u2005mOsm\/kg); high urinary sodium (73\u2005mmol\/L) and high urinary osmolality (165\u2005mOsm\/kg). Despite oral sodium supplementation and fludrocortisone treatment, sodium levels remained between 124 and 130\u2005mmol\/L. Cranial ultrasound, brain MRI and renal ultrasound were normal. The diagnosis of hyponatraemia was unpredicted and the investigation was suggestive of reset osmostat, a subtype of the syndrome of inappropriate secretion of antidiuretic hormone, characterised by a subnormal threshold for antidiuretic hormone secretion.<\/jats:p>","DOI":"10.1136\/bcr-2013-009111","type":"journal-article","created":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T03:29:05Z","timestamp":1435548545000},"page":"bcr2013009111","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Reset osmostat: a rare cause of hyponatraemia"],"prefix":"10.1136","volume":"2015","author":[{"given":"Beatriz Maia","family":"Vale","sequence":"first","affiliation":[{"name":"Hospital Pedi\u00e1trico, Centro Hospitalar Universit\u00e1rio de Coimbra, Portugal"}]},{"given":"Sofia","family":"Morais","sequence":"additional","affiliation":[{"name":"Maternidade Bissaya Barreto do Centro Hospitalar Universit\u00e1rio de Coimbra, Coimbra, Portugal"}]},{"given":"Joana","family":"Mesquita","sequence":"additional","affiliation":[{"name":"Maternidade Bissaya Barreto do Centro Hospitalar Universit\u00e1rio de Coimbra, Coimbra, Portugal"}]},{"given":"Gabriela","family":"Mimoso","sequence":"additional","affiliation":[{"name":"Maternidade Bissaya Barreto do Centro Hospitalar Universit\u00e1rio de Coimbra, Coimbra, Portugal"}]}],"member":"239","published-online":{"date-parts":[[2015,6,29]]},"reference":[{"key":"2025082800310522000_2015.jun28_1.bcr2013009111.1","unstructured":"Greenbaum LA . Electrolyte and acid-base disorders. In: Kliegman RM , Stanton B , Geme J , et al . Nelson textbook of pediatrics. 18th edn. Philadelphia: Elsevier, 2007:275\u20139."},{"key":"2025082800310522000_2015.jun28_1.bcr2013009111.2","unstructured":"Sterns R . Evaluation of the patient with hyponatremia. http:\/\/www.uptodate.com\/contents\/evaluation-of-the-patient-with-hyponatremia (accessed 20 Dec 2011)."},{"key":"2025082800310522000_2015.jun28_1.bcr2013009111.3","first-page":"2387","article-title":"Management of hyponatremia","volume":"69","author":"Goh","year":"2004","journal-title":"Am Fam Physician"},{"key":"2025082800310522000_2015.jun28_1.bcr2013009111.4","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1542\/pir.23.11.371","article-title":"Disorders of water metabolism in children: hyponatremia and hypernatremia","volume":"23","author":"Moritz","year":"2002","journal-title":"Pediatr Rev"},{"key":"2025082800310522000_2015.jun28_1.bcr2013009111.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70371-2"},{"key":"2025082800310522000_2015.jun28_1.bcr2013009111.6","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(03)00139-0"},{"key":"2025082800310522000_2015.jun28_1.bcr2013009111.7","unstructured":"Rose BD . Pathophysiology and etiology of the syndrome of inappropriate antidiuretic hormone secretion (SIADH). http:\/\/www.uptodate.com\/contents\/pathophysiology-and-etiology-of-the-syndrome-of-inappropriate-antidiuretic-hormone-secretion-siadh (accessed 20 Dec 2011)."},{"key":"2025082800310522000_2015.jun28_1.bcr2013009111.8","doi-asserted-by":"publisher","DOI":"10.1136\/fn.78.2.F81"},{"key":"2025082800310522000_2015.jun28_1.bcr2013009111.9","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-1869"},{"key":"2025082800310522000_2015.jun28_1.bcr2013009111.10","unstructured":"Sterns R . Treatment of hyponatremia: syndrome of inappropriate antidiuretic hormone secretion (SIADH) and reset osmostat. http:\/\/www.uptodate.com\/contents\/treatment-of-hyponatremia-syndrome-of-inappropriate-antidiuretic-hormone-secretion-siadh-and-reset-osmostat (accessed 20 Dec 2011)."},{"key":"2025082800310522000_2015.jun28_1.bcr2013009111.11","first-page":"11","article-title":"Chronic hyponatremia and failure to thrive in an 18 month old toddler with chronic SIADH","volume":"17","author":"Benson","year":"2010","journal-title":"Endotrends"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-009111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:31:13Z","timestamp":1756366273000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-009111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,29]]},"references-count":11,"alternative-id":["10.1136\/bcr-2013-009111"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-009111","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,29]]}}}