{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T16:40:07Z","timestamp":1745772007154,"version":"3.40.4"},"reference-count":9,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Pilomatricoma is a relatively common benign skin neoplasm originating from the hair follicle matrix cells. \u03b2-Catenin is a subunit of the cadherin protein complex. It acts as an intracellular signal transducer that influences cell differentiation and proliferation. This protein was recently involved in the formation of hair follicle-related tumours, including pilomatricomas. Tuberous sclerosis (TS) is an inherited neurocutaneous disease, which is characterised by pleomorphic features involving many organs, hamartomas in multiple organ systems and by the fact that it is usually diagnosed early in life. We reported a case of a Caucasian patient with TS and a giant pilomatricoma, both diagnosed in the adult life.<\/jats:p>","DOI":"10.1136\/bcr-2013-010382","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T11:08:40Z","timestamp":1377774520000},"page":"bcr2013010382","source":"Crossref","is-referenced-by-count":3,"title":["Giant pilomatricoma in a patient with tuberous sclerosis, both diagnosed in the adult life"],"prefix":"10.1136","volume":"2013","author":[{"given":"Cristina Isabel Pinho","family":"Resende","sequence":"first","affiliation":[]},{"given":"Joana","family":"Gomes","sequence":"additional","affiliation":[]},{"given":"Maria da Luz","family":"Duarte","sequence":"additional","affiliation":[]},{"given":"Celeste","family":"Brito","sequence":"additional","affiliation":[]}],"member":"239","published-online":{"date-parts":[[2013,8,29]]},"reference":[{"key":"2025042709094517000_2013.aug29_1.bcr2013010382.1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1365-2230.2009.03260.x","article-title":"Anetodermic pilomatricoma in a patient with tuberous sclerosis","volume":"2013","author":"Krishna","year":"2009","journal-title":"Clin Exp Dermatol"},{"key":"2025042709094517000_2013.aug29_1.bcr2013010382.2","first-page":"340","article-title":"Giant pilomatrixoma (benign calcifying epithelioma of Malherbe) of the neck and face","volume":"2013","author":"Kovacic","year":"2007","journal-title":"Dermatol Surg"},{"key":"2025042709094517000_2013.aug29_1.bcr2013010382.3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s11060-006-9134-0","article-title":"Hamartin and tuberin modulate gene transcription via \u03b2-catenin","volume":"2013","author":"Jozwiack","year":"2006","journal-title":"J Neurooncol"},{"key":"2025042709094517000_2013.aug29_1.bcr2013010382.4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jaad.2007.05.004","article-title":"Tuberous sclerosis complex: advances in diagnosis, genetics and management","volume":"2013","author":"Schwartz","year":"2007","journal-title":"J Am Acad Dermatol"},{"key":"2025042709094517000_2013.aug29_1.bcr2013010382.5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1470-2045(07)70411-4","article-title":"Possible mechanisms of disease development in tuberous sclerosis","volume":"2013","author":"Jozwiack","year":"2008","journal-title":"Lancet Oncol"},{"key":"2025042709094517000_2013.aug29_1.bcr2013010382.6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF00176283","article-title":"Giant pilomatrixoma in adult","volume":"2013","author":"Per\u010din","year":"1996","journal-title":"Eur J Plast Surg"},{"key":"2025042709094517000_2013.aug29_1.bcr2013010382.7","doi-asserted-by":"crossref","first-page":"284","DOI":"10.5021\/ad.2010.22.3.284","article-title":"The immunohistochemical patterns of the \u03b2-catenin expression in pilomatricoma","volume":"2013","author":"Kim","year":"2010","journal-title":"Ann Dermatol"},{"key":"2025042709094517000_2013.aug29_1.bcr2013010382.8","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1046\/j.1365-2133.2001.04433.x","article-title":"\u03b2-catenin expression in the transitional cell zone of pilomatricoma","volume":"2013","author":"Park","year":"2001","journal-title":"Br J Dermatol"},{"key":"2025042709094517000_2013.aug29_1.bcr2013010382.9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0002-9440(10)62958-6","article-title":"Aberrant \u03b2-catenin signaling in tuberous sclerosis","volume":"2013","author":"Mak","year":"2005","journal-title":"Am J Pathol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-010382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T16:09:52Z","timestamp":1745770192000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-010382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,29]]},"references-count":9,"alternative-id":["10.1136\/bcr-2013-010382"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-010382","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2013,8,29]]}}}