{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T21:46:08Z","timestamp":1767995168772,"version":"3.49.0"},"reference-count":30,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,5,13]]},"abstract":"<jats:p>Atrioventricular block can occur in normal children, young adults or athletes. It is also associated with underlying heart disease or occurs as a drug adverse effect. Amphotericin B is used in the treatment of invasive fungal infections. Cardiac toxicity is a rare adverse reaction. We report the case of a 9-month girl, admitted in the paediatric intensive care unit with cytomegalovirus pneumonitis. During hospitalisation the patient developed a systemic fungic infection and was medicated with liposomal amphotericin B. On the third day of treatment she began repeated episodes of bradycardia with spontaneous reversion. The investigation revealed a second-degree atrioventricular block. We excluded the misplacement of the central catheter, myocarditis or structural cardiomyopathy and suspended amphotericin. After 8\u2005days, the bradycardia episodes ceased what was consistent with the drug's half-life. Amphotericin cardiotoxic mechanism is still unclear. It may be related with alteration of myocardial membrane depolarisation.<\/jats:p>","DOI":"10.1136\/bcr-2013-202688","type":"journal-article","created":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T11:36:19Z","timestamp":1402054579000},"page":"bcr2013202688","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Atrioventricular block related to liposomal amphotericin B"],"prefix":"10.1136","volume":"2014","author":[{"given":"Bruno Fernandes","family":"Sanches","sequence":"first","affiliation":[]},{"given":"Pedro","family":"Nunes","sequence":"additional","affiliation":[]},{"given":"Helena","family":"Almeida","sequence":"additional","affiliation":[]},{"given":"M\u00f3nica","family":"Rebelo","sequence":"additional","affiliation":[]}],"member":"239","published-online":{"date-parts":[[2014,6,6]]},"reference":[{"key":"2025042705413844000_2014.jun06_1.bcr2013202688.1","unstructured":"Zimmerman F . Bradycardia in children. 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