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Overdose with the two drugs separately is common, but there are no reports of intoxication by simultaneous ingestion. High levels of carbamazepine and valproic acid can lead to severe systemic effects and management is made difficult by the absence of specific antidotes. Extracorporeal removal techniques are a good therapeutic option in these cases as they enhance the clearance by reducing the half-life of both drugs thereby preventing serious complications.<\/jats:p>","DOI":"10.1136\/bcr-2014-207761","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T11:28:04Z","timestamp":1416828484000},"page":"bcr2014207761","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Overdose with antiepileptic drugs: the efficacy of extracorporeal removal techniques"],"prefix":"10.1136","volume":"2014","author":[{"given":"Rita","family":"Moinho","sequence":"first","affiliation":[]},{"given":"Andrea","family":"Dias","sequence":"additional","affiliation":[]},{"given":"Paula","family":"Estanqueiro","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Farela Neves","sequence":"additional","affiliation":[]}],"member":"239","published-online":{"date-parts":[[2014,11,24]]},"reference":[{"key":"2025042707005161000_2014.nov24_1.bcr2014207761.1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12291"},{"key":"2025042707005161000_2014.nov24_1.bcr2014207761.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2006.01615.x"},{"key":"2025042707005161000_2014.nov24_1.bcr2014207761.3","first-page":"1","article-title":"Youth risk behavior surveillance\u2014United States, 2011","volume":"61","author":"Eaton","year":"2012","journal-title":"MMWR Surveill Summ"},{"key":"2025042707005161000_2014.nov24_1.bcr2014207761.4","first-page":"1","article-title":"Extracorporeal management of poisonings","volume":"23","author":"Mendonca","year":"2012","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"2025042707005161000_2014.nov24_1.bcr2014207761.5","first-page":"127","article-title":"Extended hemoperfusion in the treatment of acute carbamazepine intoxication","volume":"30","author":"Peces","year":"2010","journal-title":"Nefrologia"},{"key":"2025042707005161000_2014.nov24_1.bcr2014207761.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2006.00663.x"},{"key":"2025042707005161000_2014.nov24_1.bcr2014207761.7","first-page":"370","article-title":"Hemoperfusion in the treatment of acute valproic acid intoxication","volume":"27","author":"Peces","year":"2007","journal-title":"Nefrologia"},{"key":"2025042707005161000_2014.nov24_1.bcr2014207761.8","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2013.863906"},{"key":"2025042707005161000_2014.nov24_1.bcr2014207761.9","first-page":"333","article-title":"Valproic acid intoxication: sense and non-sense of haemodialysis","volume":"62","author":"Meek","year":"2004","journal-title":"Medicine"},{"key":"2025042707005161000_2014.nov24_1.bcr2014207761.10","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050698"},{"key":"2025042707005161000_2014.nov24_1.bcr2014207761.11","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.2.406"},{"key":"2025042707005161000_2014.nov24_1.bcr2014207761.12","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-006-0257-8"},{"key":"2025042707005161000_2014.nov24_1.bcr2014207761.13","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.7516"},{"key":"2025042707005161000_2014.nov24_1.bcr2014207761.14","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1111\/j.1460-9592.2006.01955.x","article-title":"Continuous venovenous hemodiafiltration to treat controlled-release carbamazepine overdose in a pediatric patient","volume":"16","author":"Yildiz","year":"2006","journal-title":"Paediatr Anaesth"},{"key":"2025042707005161000_2014.nov24_1.bcr2014207761.15","unstructured":"Rivers CM . 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