{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T13:40:04Z","timestamp":1745761204959,"version":"3.40.4"},"reference-count":19,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2015,4,10]]},"abstract":"<jats:p>The 5-aminosalicylate is widely prescribed in inflammatory bowel disease patients. Its potential for renal damage has been seldom described. We report a case of a 23-year-old man who started 5-aminosalicylate after being diagnosed with ulcerative colitis. One year after, a significant decline on his creatinine clearance was noted, however, at that time, he was on an acute flare of his bowel disease and the 5-aminosalicylate dose was increased. Six months later, his renal function kept worsening and, on drug-induced toxicity suspicion, 5-aminosalicylate was halted and a kidney biopsy demonstrated a chronic tubulointerstitial nephritis. Steroids and azathioprine were started leading to partial recovery and stabilisation of his renal function. Physicians who prescribe 5-aminosalicylate to patients with inflammatory bowel disease should be aware of this adverse event.<\/jats:p>","DOI":"10.1136\/bcr-2014-207928","type":"journal-article","created":{"date-parts":[[2015,5,2]],"date-time":"2015-05-02T11:30:07Z","timestamp":1430566207000},"page":"bcr2014207928","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Chronic tubulointerstitial nephritis induced by 5-aminosalicylate in an ulcerative colitis patient: a rare but serious adverse event"],"prefix":"10.1136","volume":"2015","author":[{"given":"Pedro","family":"Magalh\u00e3es-Costa","sequence":"first","affiliation":[]},{"given":"Leopoldo","family":"Matos","sequence":"additional","affiliation":[]},{"given":"Cristina","family":"Chagas","sequence":"additional","affiliation":[]}],"member":"239","published-online":{"date-parts":[[2015,5,2]]},"reference":[{"key":"2025042706101929000_2015.may02_1.bcr2014207928.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2012.09.002"},{"key":"2025042706101929000_2015.may02_1.bcr2014207928.2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.ndt.a027349"},{"key":"2025042706101929000_2015.may02_1.bcr2014207928.3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7161.795"},{"key":"2025042706101929000_2015.may02_1.bcr2014207928.4","doi-asserted-by":"publisher","DOI":"10.1159\/000188024"},{"key":"2025042706101929000_2015.may02_1.bcr2014207928.5","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.ndt.a027787"},{"key":"2025042706101929000_2015.may02_1.bcr2014207928.6","first-page":"1031","article-title":"Case report\u2013acute interstitial nephritis due to 5-aminosalicylic acid","volume":"143","author":"Mehta","year":"1990","journal-title":"Can Med Assoc J"},{"key":"2025042706101929000_2015.may02_1.bcr2014207928.7","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.10.1493"},{"key":"2025042706101929000_2015.may02_1.bcr2014207928.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)89466-1"},{"key":"2025042706101929000_2015.may02_1.bcr2014207928.9","first-page":"265","article-title":"Mesalazine-associated tubulo-interstitial nephritis in inflammatory bowel disease","volume":"49","author":"Calvi\u00f1o","year":"1998","journal-title":"Clin Nephrol"},{"key":"2025042706101929000_2015.may02_1.bcr2014207928.10","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.4.563"},{"key":"2025042706101929000_2015.may02_1.bcr2014207928.11","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20099"},{"key":"2025042706101929000_2015.may02_1.bcr2014207928.12","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.10.1348"},{"key":"2025042706101929000_2015.may02_1.bcr2014207928.13","doi-asserted-by":"publisher","DOI":"10.5414\/CNP61083"},{"key":"2025042706101929000_2015.may02_1.bcr2014207928.14","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.03.016"},{"key":"2025042706101929000_2015.may02_1.bcr2014207928.15","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.4.536"},{"key":"2025042706101929000_2015.may02_1.bcr2014207928.16","doi-asserted-by":"publisher","DOI":"10.1097\/01.MIB.0000185402.65288.19"},{"key":"2025042706101929000_2015.may02_1.bcr2014207928.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2010.10.002"},{"key":"2025042706101929000_2015.may02_1.bcr2014207928.18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2036.2000.00683.x","article-title":"Review article: interstitial nephritis associated with the use of mesalazine in inflammatory bowel disease","volume":"14","author":"Corrigan","year":"2000","journal-title":"Aliment Pharmacol Ther"},{"key":"2025042706101929000_2015.may02_1.bcr2014207928.19","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-004-1411-6"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2014-207928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T13:10:28Z","timestamp":1745759428000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2014-207928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,2]]},"references-count":19,"alternative-id":["10.1136\/bcr-2014-207928"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2014-207928","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2015,5,2]]}}}