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The diagnosis was challenging, initially mimicking infectious disease, and it required an extensive investigation that ultimately revealed the characteristic clinical, histopathological and cytogenetic features of HSTCL. The clinical course was aggressive, and despite multiagent chemotherapy, the patient died 4\u2005months after the diagnosis. This case highlights the difficulty of diagnosing HSTCL and the importance of considering it in a differential diagnosis of hepatosplenomegaly in young men who present with constitutional symptoms and no lymphadenopathy.<\/jats:p>","DOI":"10.1136\/bcr-2016-214414","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T14:28:54Z","timestamp":1459434534000},"page":"bcr2016214414","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Hepatosplenic T-cell lymphoma in a young immunocompetent man"],"prefix":"10.1136","volume":"2016","author":[{"given":"Maja","family":"Petrova","sequence":"first","affiliation":[]},{"given":"Manuel Mendes","family":"Gomes","sequence":"additional","affiliation":[]},{"given":"Jose Pedro Nascimento","family":"Carda","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Pereira de 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