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The heterogeneity inherent in different pNETs should be acknowledged, as it may influence treatment response. We report a case of an unresectable pNET with metastatic disease, which exhibited a partial response to neoadjuvant chemotherapy, enabling an R0 resection.<\/jats:p>","DOI":"10.1136\/bcr-2024-263346","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T05:35:26Z","timestamp":1758260126000},"page":"e263346","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Advanced pancreatic neuroendocrine tumour: the success of \u2018neoadjuvant\u2019 chemotherapy"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5566-9068","authenticated-orcid":false,"given":"Maria Salom\u00e9","family":"Serranito","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, Hospital Curry Cabral, Unidade Local de Sa\u00fade S\u00e3o Jos\u00e9, Lisboa, Portugal"}]},{"given":"Leandro","family":"Augusto Silva","sequence":"additional","affiliation":[{"name":"Instituto Portugu\u00eas de Oncologia de Coimbra Francisco Gentil, EPE, Coimbra, Portugal"}]},{"given":"Andreia","family":"Martins Fernandes","sequence":"additional","affiliation":[{"name":"Instituto Portugu\u00eas de Oncologia de Coimbra Francisco Gentil, EPE, Coimbra, Portugal"}]},{"given":"Ana Rita","family":"Elvas","sequence":"additional","affiliation":[{"name":"Instituto Portugu\u00eas de Oncologia de Coimbra Francisco Gentil, EPE, Coimbra, Portugal"}]},{"given":"Isabel","family":"Domingues","sequence":"additional","affiliation":[{"name":"Unidade Local de Sa\u00fade da Regi\u00e3o de Aveiro, EPE, Aveiro, Portugal"}]},{"given":"Rui","family":"Martins","sequence":"additional","affiliation":[{"name":"Instituto Portugu\u00eas de Oncologia de Coimbra Francisco Gentil, EPE, Coimbra, Portugal"}]},{"given":"Raquel","family":"Martins","sequence":"additional","affiliation":[{"name":"Instituto Portugu\u00eas de Oncologia de Coimbra 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therapy in pancreatic neuroendocrine neoplasms: A systematic review and meta-analysis","volume":"12","author":"Li","year":"2022","journal-title":"Front Oncol"},{"key":"2025091822352083000_18.9.e263346.4","first-page":"359","article-title":"Critical updates in neuroendocrine tumors: Version 9 American Joint Committee on Cancer staging system for gastroenteropancreatic neuroendocrine tumors","volume":"74","author":"Chauhan","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"2025091822352083000_18.9.e263346.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.03.304"},{"key":"2025091822352083000_18.9.e263346.6","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000001454"},{"key":"2025091822352083000_18.9.e263346.7","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1097\/MPA.0000000000001597","article-title":"The North American Neuroendocrine Tumor Society Consensus Guidelines for Surveillance and Medical Management of Pancreatic Neuroendocrine 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