{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:00:52Z","timestamp":1771484452143,"version":"3.50.1"},"reference-count":38,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Compared with current imaging methods, the diagnostic performance and the advantages and limitations of optical coherence tomography angiography (OCTA) remain unclear. We performed a systematic review and meta-analysis of studies investigating vessel density (VD) in patients with glaucoma using OCTA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a literature search on PubMed, Scopus, Web of Science, ISI Conference Proceedings and Google Scholar, along with a manual search, from January 2006 to March 2018. We included prospective studies that used OCTA to compare the VD in glaucomatous eyes with healthy control eyes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 3045 screened articles, 24 were included in a broad characterisation and 18 in the meta-analysis. We observed a statistically significant reduction in the mean peripapillary VD (MPVD) in glaucoma (MPVD: 57.53%, 95%\u2009CI 52.60 to 62.46, p&lt; 0.001) compared with controls (MPVD: 65.47%, 95%\u2009CI 59.82 to 71.11; standardised mean difference [SMD], \u20131.41, 95%\u2009CI \u20131.62 to \u20131.20, p&lt; 0.001) for 888 glaucomatous and 475 healthy eyes, and also in the mean-whole optic nerve image VD (SMD, \u20139.63, 95%\u2009CI \u201310.22 to \u20139.03, p&lt;0.001), mean inside-disc VD (SMD, \u2212 9.51, 95% CI \u201312.66 to \u20136.36, p&lt;0.05) and mean parafoveal VD (SMD, \u20133.92, 95%\u2009CI \u20134.73 to \u20133.12, p&lt;0.001). Subgroup analyses revealed a significant difference in the MPVD across glaucoma subtypes and OCTA devices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This suggests the diagnostic utility of OCTA in detecting glaucomatous eyes; however, further longitudinal prospective studies are welcomed to characterise vascular changes in glaucoma.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjophthalmol-2018-313461","type":"journal-article","created":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T22:19:23Z","timestamp":1549491563000},"page":"1677-1684","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Diagnostic performance of optical coherence tomography angiography in glaucoma: a systematic review and meta-analysis"],"prefix":"10.1136","volume":"103","author":[{"given":"Ana I M","family":"Miguel","sequence":"first","affiliation":[]},{"given":"Andr\u00e9 B","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Luis F","family":"Azevedo","sequence":"additional","affiliation":[]}],"member":"239","published-online":{"date-parts":[[2019,2,6]]},"reference":[{"key":"2020050713023699000_103.11.1677.1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3192"},{"key":"2020050713023699000_103.11.1677.2","doi-asserted-by":"crossref","unstructured":"Chan KKW , Tang F , Tham CCY , et al . 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Bellingham: Spie-Int Soc Optical Engineering, 2015."},{"key":"2020050713023699000_103.11.1677.5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000488495","article-title":"Optical coherence tomography angiography in glaucoma: a review","volume":"60","author":"Van Melkebeke","year":"2018","journal-title":"Ophthalmic Res"},{"key":"2020050713023699000_103.11.1677.6","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1364\/BOE.3.003127","article-title":"Quantitative OCT angiography of optic nerve head blood flow","volume":"3","author":"Jia","year":"2012","journal-title":"Biomedical Optics Express"},{"key":"2020050713023699000_103.11.1677.7","unstructured":"Collaboration TC . 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