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We intended to perform a systematic review of studies focusing on longitudinal changes in peripapillary and macular VD measurements in glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A search was performed across MEDLINE, Scopus, ISI Web of Science and Google Scholar, using the following query from inception until 20 September 2019: ((\u201coptical coherence tomography angiography\u201d[tiab]) OR (optical coherence tomography angiography[MeSH]) OR (\u201cOCTA\u201d[tiab]) OR (\u201cOCT-A\u201d[tiab]) OR (\u201cangio-OCT\u201d[tiab]) OR (\u201cOCT- angiography\u201d[tiab]) OR (\u201cOCT-angio\u201d[tiab]) OR (\u201cOCT-angiographie\u201d[tiab])) AND (glaucom*[tiab] OR glaucoma[MeSH]). Prospective studies that quantitatively assessed the longitudinal changes in VD in glaucoma with at least 3\u2009months of follow-up were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten out of 4516 studies were included. The rate of VD change in glaucoma varied from 0.036\/year to 1.08\/year and 1.3% to 3.2% per year, with significantly different rates between glaucoma and healthy controls. Five studies assessed VD change after glaucoma surgery, obtaining variable results, ranging from a temporary VD decrease to increase after 3\u2009months. Meta-analysis was not possible due to a wide variation in methods, measurements and region of VD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OCTA is a non-invasive technology, which shows promise in glaucoma. Measures should be taken to increase the quality and standardise the methodology of VD measures in OCTA longitudinal studies, for future meta-analyses.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjophthalmol-2020-318166","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T18:20:16Z","timestamp":1610734816000},"page":"667-675","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["OCT-angiography detects longitudinal microvascular changes in glaucoma: a systematic review"],"prefix":"10.1136","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1213-0315","authenticated-orcid":false,"given":"Ana","family":"Miguel","sequence":"first","affiliation":[]},{"given":"Andr\u00e9","family":"Silva","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7816-816X","authenticated-orcid":false,"given":"Joao","family":"Barbosa-Breda","sequence":"additional","affiliation":[]},{"given":"Luis","family":"Azevedo","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7331-388X","authenticated-orcid":false,"given":"Abdulkarim","family":"Abdulrahman","sequence":"additional","affiliation":[]},{"given":"Esther","family":"Hereth","sequence":"additional","affiliation":[]},{"given":"Luis","family":"Abeg\u00e3o Pinto","sequence":"additional","affiliation":[]},{"given":"Yves","family":"Lachkar","sequence":"additional","affiliation":[]},{"given":"Ingeborg","family":"Stalmans","sequence":"additional","affiliation":[]}],"member":"239","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"key":"2022042102301515000_106.5.667.1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3192"},{"key":"2022042102301515000_106.5.667.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.013"},{"key":"2022042102301515000_106.5.667.3","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.3.003127"},{"key":"2022042102301515000_106.5.667.4","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000488495","article-title":"Optical coherence tomography angiography in glaucoma: a review","volume":"60","author":"Van Melkebeke","year":"2018","journal-title":"Ophthalmic Res"},{"key":"2022042102301515000_106.5.667.5","doi-asserted-by":"crossref","unstructured":"Auyeung K , Auyeung K , Kono R . 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