{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T17:44:01Z","timestamp":1759772641499,"version":"3.41.2"},"reference-count":33,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"unspecified","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["AUC00015-17"],"award-info":[{"award-number":["AUC00015-17"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1128907"],"award-info":[{"award-number":["OPP1128907"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Health Care Inform"],"accepted":{"date-parts":[[2021,11,10]]},"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The structural maturation of the skin is considered a potential marker of pregnancy dating. This study investigated the correlation between the morphometrical skin characteristics with the pregnancy chronology to propose models for predicting gestational age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A cross-sectional analysis selected 35 corpses of newborns. The biopsy was performed up to 48 hours after death in the periumbilical abdomen, palm and sole regions. Pregnancy chronology was based on the obstetric ultrasound before 14 weeks. The dimensions of the skin layers, area of glands and connective fibrous tissue were measured with imaging software support. Univariate and multivariate regression models on morphometric values were used to predict gestational age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Gestational age at birth ranged from 20.3 to 41.2 weeks. Seventy-one skin specimens resulted in the analysis of 1183 digital histological images. The correlation between skin thickness and gestational age was positive and strong in both regions of the body. The highest univariate correlation between gestational age and skin thickness was using the epidermal layer dimensions, in palm (r=0.867, p&lt;0.001). The multivariate modelling with the thickness of the abdominal epidermis, the dermis and the area of the sebaceous glands adjusted had the highest correlation with gestational age (r=0.99, p&lt;0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The thickness of the protective epidermal barrier is, in itself, a potential marker of pregnancy dating. However, sets of values obtained from skin morphometry enhanced the estimation of the gestational age. Such findings may support non-invasive image approaches to estimate pregnancy dating with various clinical applications.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjhci-2021-100476","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T11:24:13Z","timestamp":1638876253000},"page":"e100476","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Association between the chronology of gestation and the morphometrical skin characteristics at childbirth: a development of predictive model"],"prefix":"10.1136","volume":"28","author":[{"given":"Ingrid Michelle Fonseca","family":"de Souza","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"}]},{"given":"Gabriela Luiza Nogueira","family":"Vitral","sequence":"additional","affiliation":[{"name":"Pediatrics, Postgraduation Program, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"}]},{"given":"Marcelo Vidigal","family":"Caliari","sequence":"additional","affiliation":[{"name":"Department of General Pathology, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6374-9295","authenticated-orcid":false,"given":"Zilma Silveira Nogueira","family":"Reis","sequence":"additional","affiliation":[{"name":"Informatics Health Center, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"}]}],"member":"239","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"key":"2025072913430330000_28.1.e100476.1","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12942"},{"key":"2025072913430330000_28.1.e100476.2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.2003.00142.x"},{"key":"2025072913430330000_28.1.e100476.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2012.06.005"},{"key":"2025072913430330000_28.1.e100476.4","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/srt.12719","article-title":"Skin thickness dimensions in histological section measurement during late-fetal and neonatal developmental period: a systematic review","volume":"25","author":"de-Souza","year":"2019","journal-title":"Skin Res Technol"},{"key":"2025072913430330000_28.1.e100476.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2006.09.008"},{"key":"2025072913430330000_28.1.e100476.6","unstructured":"Steven B , Hoath HIM . 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