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This project aims to understand the burden of neurological complications of breast cancer treatment in Northern Portugal, and their role as mediator of the impact of the treatment in different dimensions of the patients\u2019 quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>A prospective cohort study was designed to include 500 patients with breast cancer, to be followed for 3\u2005years. The patients were recruited at the Portuguese Oncology Institute of Porto and evaluations were planned at different stages: pretreatment, after surgery, after chemotherapy (whenever applicable) and at 1 and 3\u2005years after enrolment. Patients diagnosed with neuropathic pain or chemotherapy-induced peripheral neuropathy (subcohorts), were also evaluated at the moment of confirmation of clinical diagnosis of the neurological complication and 6\u2005months later. In each of the follow-up periods, a neurological examination has been performed by a neurologist. Data were collected on sociodemographic and clinical characteristics, quality of life, sleep quality, and anxiety and depression. Between January and December 2012, we recruited and conducted the baseline evaluation of 506 participants. The end of the follow-up period is scheduled for December 2015.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The study protocol was approved by the Ethics Committee of the Portuguese Oncology Institute of Porto and all patients provided written informed consent. All study procedures were developed in order to assure data protection and confidentiality. Results from this project will be disseminated in international peer-reviewed journals and presented in relevant conferences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2014-006301","type":"journal-article","created":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T02:59:51Z","timestamp":1414551591000},"page":"e006301","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Neurological complications of breast cancer: study protocol of a prospective cohort study"],"prefix":"10.1136","volume":"4","author":[{"given":"Susana","family":"Pereira","sequence":"first","affiliation":[{"name":"Instituto Portugu\u00eas de Oncologia, Porto, Portugal"},{"name":"EPI Unit, Instituto de Sa\u00fade P\u00fablica da Universidade do Porto (ISPUP), Porto, Portugal"},{"name":"Departamento de Epidemiologia Cl\u00ednica, Medicina Preditiva e Sa\u00fade P\u00fablica, Faculdade de Medicina, Universidade do Porto, Porto, Portugal"}]},{"given":"Filipa","family":"Fontes","sequence":"additional","affiliation":[{"name":"EPI Unit, Instituto de Sa\u00fade P\u00fablica da Universidade do Porto (ISPUP), Porto, Portugal"},{"name":"Departamento de Epidemiologia Cl\u00ednica, Medicina Preditiva e Sa\u00fade P\u00fablica, Faculdade de Medicina, Universidade do Porto, Porto, Portugal"}]},{"given":"Teresa","family":"Sonin","sequence":"additional","affiliation":[{"name":"Instituto Portugu\u00eas de Oncologia, Porto, Portugal"}]},{"given":"Teresa","family":"Dias","sequence":"additional","affiliation":[{"name":"Instituto Portugu\u00eas de Oncologia, Porto, Portugal"}]},{"given":"Maria","family":"Fragoso","sequence":"additional","affiliation":[{"name":"Instituto Portugu\u00eas de Oncologia, Porto, Portugal"}]},{"given":"Jos\u00e9","family":"Castro-Lopes","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Experimental, Faculdade de Medicina, Universidade do Porto, Porto, Portugal"},{"name":"Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal"}]},{"given":"Nuno","family":"Lunet","sequence":"additional","affiliation":[{"name":"EPI Unit, Instituto de Sa\u00fade P\u00fablica da Universidade do Porto (ISPUP), Porto, Portugal"},{"name":"Departamento de Epidemiologia Cl\u00ednica, Medicina Preditiva e Sa\u00fade P\u00fablica, Faculdade de Medicina, Universidade do Porto, Porto, Portugal"}]}],"member":"239","published-online":{"date-parts":[[2014,10,28]]},"reference":[{"key":"2025121604543140000_4.10.e006301.1","unstructured":"Ferlay J , Soerjomataram I , Ervik M , et al . 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