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Among these communication impairments, 3 major challenges include: (1) dysarthria, consisting of orofacial motor dysfunction and dysprosody, which is linked to the neurodegenerative processes; (2) effects of the pharmacological treatment, which vary according to the disease stage; and (3) particular speech modifications that may be language-specific, that is, dependent on the language spoken by the patients. The main objective of the FraLusoPark project is to provide a thorough evaluation of changes in PD speech as a result of pharmacological treatment and disease duration in 2 different languages (French vs European Portuguese).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>Individuals with PD are enrolled in the study in France (N=60) and Portugal (N=60). Their global motor disability and orofacial motor functions is assessed with specific clinical rating scales, without (OFF) and with (ON) pharmacological treatment. 2 groups of 60 healthy age-matched volunteers provide the reference for between-group comparisons. Along with the clinical examinations, several speech tasks are recorded to obtain acoustic and perceptual measures. Patient-reported outcome measures are used to assess the psychosocial impact of dysarthria on quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The study has been approved by the local responsible committees on human experimentation and is conducted in accordance with the ethical standards. A valuable large-scale database of speech recordings and metadata from patients with PD in France and Portugal will be constructed. Results will be disseminated in several articles in peer-reviewed journals and in conference presentations. Recommendations on how to assess speech and voice disorders in individuals with PD to monitor the progression and management of symptoms will be provided.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02753192\" ext-link-type=\"uri\">NCT02753192<\/jats:ext-link>\n                      , Pre-results.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2016-012885","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T22:40:29Z","timestamp":1479422429000},"page":"e012885","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Dysarthria in individuals with Parkinson's disease: a protocol for a binational, cross-sectional, case-controlled study in French and European Portuguese (FraLusoPark)"],"prefix":"10.1136","volume":"6","clinical-trial-number":[{"clinical-trial-number":"nct02753192","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3375-4787","authenticated-orcid":false,"given":"Serge","family":"Pinto","sequence":"first","affiliation":[{"name":"Aix Marseille Universit\u00e9, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL), Aix-en-Provence, France"},{"name":"Brain and Language Research Institute, Aix-en-Provence, France"}]},{"given":"Rita","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Campus Neurol\u00f3gico S\u00e9nior (CNS), Torres Vedras, Portugal"},{"name":"Faculty of Medicine, Instituto de Medicina Molecular (IMM), University of Lisbon, Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3398-606X","authenticated-orcid":false,"given":"Jasmin","family":"Sadat","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL), Aix-en-Provence, France"},{"name":"Brain and Language Research Institute, Aix-en-Provence, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8524-8731","authenticated-orcid":false,"given":"Isabel","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Instituto de Medicina Molecular (IMM), University of Lisbon, Lisbon, Portugal"},{"name":"Speech Therapy Department, Escola Superior de Saude do Alcoit\u00e3o, Alcabideche, Portugal"}]},{"given":"C\u00e9line","family":"Mercier","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL), 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Language Research Institute, Aix-en-Provence, France"}]},{"given":"Pedro","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Instituto de Medicina Molecular (IMM), University of Lisbon, Lisbon, Portugal"},{"name":"Centre of Linguistics, School of Arts and Humanities, University of Lisbon, Lisbon, Portugal"}]},{"given":"Mariapaola","family":"D'Imperio","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL), Aix-en-Provence, France"},{"name":"Brain and Language Research Institute, Aix-en-Provence, France"}]},{"given":"S\u00f3nia","family":"Frota","sequence":"additional","affiliation":[{"name":"Centre of Linguistics, School of Arts and Humanities, University of Lisbon, Lisbon, Portugal"}]},{"given":"Alban","family":"Letanneux","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, Centre National de la Recherche 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