{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T13:15:14Z","timestamp":1765890914164,"version":"3.48.0"},"reference-count":37,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2017,5,22]]},"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Epidemiological evidence suggests that physical activity has a positive effect on reducing glycated haemoglobin A1c (HbA1c) levels not only in diabetics, but also in healthy subjects. Moreover, a positive association of HbA1c levels with cardiovascular disease and mortality in non-diabetic populations has recently been reported. This is a protocol for a systematic review and meta-analysis aiming to estimate the effects of physical activity on glycaemic control measured by HbA1c levels in non-diabetic populations; and to determine which type of physical activity has a greater influence on glycaemic control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>The search will be conducted using MEDLINE, EMBASE, the Cochrane Library and Web of Science databases from inception to mid-2017. Randomised controlled trials, non-randomised experimental studies and controlled pre\u2013post studies written in English, Portuguese, French or Spanish will be included. The Cochrane Collaboration\u2019s tool and The Quality Assessment Tool for Quantitative Studies will be used to assess the risk of bias for studies included in the systematic review. Standardised pre\u2013post intervention mean differences of HbA1c will be calculated as the primary outcome. Subgroup analyses will be performed based on the characteristics of physical activity intervention and population included in the studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This systematic review will synthesise evidence on the association of physical activity and HbA1c in non-diabetic populations. This study is important from the clinical and public health point because it will estimate the effect of physical activity on the glycemic control, and it will also examine which is the type of physical activity that should be recommended for preventing type 2 diabetes and its complications. The results will be disseminated by publication in a peer-reviewed journal. Ethical approval will not be required because the data used for this systematic review will be obtained from published studies and there will be no concerns about privacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>PROSPERO CRD42016050991.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2016-015801","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T20:40:28Z","timestamp":1500583228000},"page":"e015801","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["The effects of physical activity interventions on glycated haemoglobin A1c in non-diabetic populations: a protocol for a systematic review and meta-analysis"],"prefix":"10.1136","volume":"7","author":[{"given":"I","family":"Cavero-Redondo","sequence":"first","affiliation":[{"name":"Universidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, Spain"}]},{"given":"B","family":"Peleteiro","sequence":"additional","affiliation":[{"name":"EPI Unit, Instituto de Sa\u00fade P\u00fablica, Universidade do Porto, Porto, Portugal"},{"name":"Departamento de Ci\u00eancias da Sa\u00fade P\u00fablica e Forenses e Educa\u00e7\u00e3o M\u00e9dica, Faculdade de Medicina, Universidade do Porto, Porto, Portugal"}]},{"given":"C","family":"\u00c1lvarez-Bueno","sequence":"additional","affiliation":[{"name":"Universidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, Spain"}]},{"given":"M","family":"Garrido-Miguel","sequence":"additional","affiliation":[{"name":"Universidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, Spain"}]},{"given":"E G","family":"Artero","sequence":"additional","affiliation":[{"name":"SPORT Research Group (CTS-1024), Area of Physical Education and Sport, University of Almer\u00eda, Almer\u00eda, Spain"}]},{"given":"V","family":"Martinez-Vizcaino","sequence":"additional","affiliation":[{"name":"Universidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, Spain"},{"name":"Universidad Aut\u00f3noma de Chile, Facultad de Ciencias de la Salud, Talca, Chile"}]}],"member":"239","published-online":{"date-parts":[[2017,7,20]]},"reference":[{"key":"2025121605102993000_7.7.e015801.1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-S005"},{"key":"2025121605102993000_7.7.e015801.2","unstructured":"World Health Organization. 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