{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T20:58:35Z","timestamp":1765832315630,"version":"3.48.0"},"reference-count":40,"publisher":"BMJ","issue":"7","license":[{"start":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T00:00:00Z","timestamp":1627084800000},"content-version":"unspecified","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2021,6,9]]},"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Identification and characterisation of single allergens at molecular level is important. Component-resolved diagnosis offers the possibility of higher diagnostic precision, thereby allowing better patient management. House dust mites (HDM) have a worldwide distribution. Studies from different countries have shown that IgE-mediated allergy to storage mites (SM) is important in rural and urban populations. With the availability of HDM and SM molecular allergen components, studies have investigated whether different molecular sensitisation profiles are associated with clinical disease outcomes. However, no previous systematic review has synthesised the underlying evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>\n                      We will search Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Methodology Register), MEDLINE, EMBASE, CINAHL, AMED, ISI Web of Science (Science and Social Science Index) from inception to March 2020. Unpublished and ongoing work, as well as research in progress will be searched in\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"www.ClinicalTrials.gov\">www.ClinicalTrials.gov<\/jats:ext-link>\n                      ;\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"www.controlledtrials.com\">www.controlledtrials.com<\/jats:ext-link>\n                      and\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"wwwanzctrorgau\">wwwanzctrorgau<\/jats:ext-link>\n                      . We will contact an international panel of experts in this field. No language restrictions will apply; translations will be undertaken where necessary. The Critical Appraisal Skills Programme quality assessment tool will be used to appraise the methodological quality of included studies. A descriptive summary with data tables will be constructed, and if adequate, meta-analysis using random effects will be performed. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist will be followed for reporting.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Since this systematic review will be only based on published and retrievable literature, no ethics approval is required. We will publish the systematic review in an international peer-reviewed journal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>reviewregistry959.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2020-046519","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T12:46:13Z","timestamp":1627303573000},"page":"e046519","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["House dust mite (HDM) and storage mite (SM) molecular sensitisation profiles and association with clinical outcomes in allergic asthma and rhinitis: protocol for a systematic review"],"prefix":"10.1136","volume":"11","author":[{"given":"Filipa","family":"Matos-Semedo","sequence":"first","affiliation":[{"name":"Department of Immunoallergy, Hospital da Luz, Lisbon, Portugal"},{"name":"Faculty of Health Sciences, University of Beira Interior, Covilh\u00e3, Portugal"}]},{"given":"C\u00edntia","family":"Cruz","sequence":"additional","affiliation":[{"name":"Department of Immunoallergy, Hospital da Luz, Lisbon, Portugal"}]},{"given":"Filipe","family":"In\u00e1cio","sequence":"additional","affiliation":[{"name":"Department of Immunoallergology, Hospital de S\u00e3o Bernardo, Centro Hospitalar de Set\u00fabal, Set\u00fabal, Portugal"}]},{"given":"Jorge M R","family":"Gama","sequence":"additional","affiliation":[{"name":"Mathematics, Centre of Mathematics and Applications, University of Beira Interior, Covilh\u00e3, Portugal"}]},{"given":"Bright I","family":"Nwaru","sequence":"additional","affiliation":[{"name":"Krefting Research Centre, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 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