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This study aims to explore the influence of the acculturation process and dietary acculturation on the lifestyle and nutritional and health status of CPLP immigrants in Portugal and Spain, focusing on two Iberian contexts: Lisbon Metropolitan Area and the Basque Country.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and analysis<\/jats:title><jats:p>A mixed methods sequential explanatory design, combining cross-sectional studies and semistructured interviews. Official data will also be analysed. Primary data will be collected through a questionnaire and assessment of nutritional status and body composition. The estimated samples sizes are 1061 adults (\u226518 years old) in the Lisbon Metropolitan Area and 573 in the Basque Country. Time-location sampling will be used for the quantitative component and non-probabilistic sampling for the qualitative component. If safety conditions are not guaranteed due to the COVID-19 pandemic, online studies will be conducted. The semistructured interviews will complement the questionnaire data and extend knowledge about the process of acculturation of CPLP immigrants and their relationship with eating habits and physical activity. Thematic analysis will be used for qualitative data. Triangulation of data derived from different methods will be carried out. An integrative approach will be used to address potential discrepancies in findings and limitations inherent to the study design. As inter-method discrepancies may occur, triangulation protocol will be used, elaborating a \u2018convergence coding matrix\u2019 to display findings emerging from each component of the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ethics and dissemination<\/jats:title><jats:p>Ethical approval was obtained through the IHMT Ethics Council (Doc No 20\/2020), Portugal, and it was submitted to the Ethics Committee of the UPV\/EHU (Doc No under revision), Spain.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2021-048818","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T16:01:00Z","timestamp":1625846460000},"page":"e048818","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Mixed methods study protocol to explore acculturation, lifestyles and health of immigrants from the Community of Portuguese-Speaking Countries in two Iberian contexts: how to face uncertainties amidst the COVID-19 pandemic"],"prefix":"10.1136","volume":"11","author":[{"given":"Daniela","family":"Alves","sequence":"first","affiliation":[]},{"given":"Isabel","family":"Craveiro","sequence":"additional","affiliation":[]},{"given":"Nekane","family":"Basabe","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9710-1945","authenticated-orcid":false,"given":"Luzia","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]}],"member":"239","published-online":{"date-parts":[[2021,7,9]]},"reference":[{"key":"2021070908504153000_11.7.e048818.1","unstructured":"Instituto Cam\u00f5es . 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