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We identified 13 802 hospital stays by older adults who returned home involving 8878 separate patients over 64 years old.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcome measures<\/jats:title><jats:p>Sociodemographic characteristics, medical conditions and drug regimen data associated with risk of readmission within 30 days of discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall 30-day hospital readmission rate was 7.8%. Adjusted multivariate analyses revealed increased risk of hospital readmission for patients with longer hospital length of stay (OR=1.014 per additional day; 95%\u2009CI 1.006 to 1.021), impaired mobility (OR=1.218; 95%\u2009CI 1.039 to 1.427), multimorbidity (OR=1.419 per additional International Classification of Diseases, 10th Revision condition; 95%\u2009CI 1.282 to 1.572), tumorous disease (OR=2.538; 95%\u2009CI 2.089 to 3.082), polypharmacy (OR=1.043 per additional drug prescribed; 95%\u2009CI 1.028 to 1.058), and certain specific drugs, including antiemetics and antinauseants (OR=3.216 per additional drug unit taken; 95%\u2009CI 1.842 to 5.617), antihypertensives (OR=1.771; 95%\u2009CI 1.287 to 2.438), drugs for functional gastrointestinal disorders (OR=1.424; 95%\u2009CI 1.166 to 1.739), systemic hormonal preparations (OR=1.207; 95%\u2009CI 1.052 to 1.385) and vitamins (OR=1.201; 95%\u2009CI 1.049 to 1.374), as well as concurrent use of beta-blocking agents and drugs for acid-related disorders (OR=1.367; 95%\u2009CI 1.046 to 1.788).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Thirty-day hospital readmission risk was associated with longer hospital length of stay, health disorders, polypharmacy and drug regimens. The drug regimen patterns increasing the risk of hospital readmission were very heterogeneous. 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