{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:41:36Z","timestamp":1768552896732,"version":"3.49.0"},"reference-count":10,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"unspecified","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["101016216"],"award-info":[{"award-number":["101016216"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2021,10,8]]},"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>unCoVer\u2014Unravelling data for rapid evidence-based response to COVID-19\u2014is a Horizon 2020-funded network of 29 partners from 18 countries capable of collecting and using real-world data (RWD) derived from the response and provision of care to patients with COVID-19 by health systems across Europe and elsewhere. unCoVer aims to exploit the full potential of this information to rapidly address clinical and epidemiological research questions arising from the evolving pandemic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>From the onset of the COVID-19 pandemic, partners are gathering RWD from electronic health records currently including information from over 22 000 hospitalised patients with COVID-19, and national surveillance and screening data, and registries with over 1 900 000 COVID-19 cases across Europe, with continuous updates. These heterogeneous datasets will be described, harmonised and integrated into a multi-user data repository operated through Opal-DataSHIELD, an interoperable open-source server application. Federated data analyses, without sharing or disclosing any individual-level data, will be performed with the objective to reveal patients\u2019 baseline characteristics, biomarkers, determinants of COVID-19 prognosis, safety and effectiveness of treatments, and potential strategies against COVID-19, as well as epidemiological patterns. These analyses will complement evidence from efficacy\/safety clinical trials, where vulnerable, more complex\/heterogeneous populations and those most at risk of severe COVID-19 are often excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>After strict ethical considerations, databases will be available through a federated data analysis platform that allows processing of available COVID-19 RWD without disclosing identification information to analysts and limiting output to data aggregates. Dissemination of unCoVer\u2019s activities will be related to the access and use of dissimilar RWD, as well as the results generated by the pooled analyses. Dissemination will include training and educational activities, scientific publications and conference communications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-055630","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T11:50:56Z","timestamp":1637236256000},"page":"e055630","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Unravelling data for rapid evidence-based response to COVID-19: a summary of the unCoVer protocol"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0096-6238","authenticated-orcid":false,"given":"Jos\u00e9 L.","family":"Pe\u00f1alvo","sequence":"first","affiliation":[{"name":"Unit of Non-Communicable Diseases, Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4957-4235","authenticated-orcid":false,"given":"Elly","family":"Mertens","sequence":"additional","affiliation":[{"name":"Unit of Non-Communicable Diseases, Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium"}]},{"given":"Enisa","family":"Ademovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina"}]},{"given":"Seval","family":"Akgun","sequence":"additional","affiliation":[{"name":"Public Health Department, Baskent University Faculty of Medicine, Ankara, Turkey"}]},{"given":"Ana L\u00facia","family":"Baltazar","sequence":"additional","affiliation":[{"name":"Scientific-Pedagogical Unit of Dietetics and Nutrition, Coimbra Health School, Polytechnic Institute of Coimbra, Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0108-6822","authenticated-orcid":false,"given":"Dora","family":"Buonfrate","sequence":"additional","affiliation":[{"name":"Department of Infectious Tropical Diseases and Microbiology, IRCCS Ospedale Sacro Cuore Don Calabria, Negrar, Italy"}]},{"given":"Miran","family":"\u010coklo","sequence":"additional","affiliation":[{"name":"Centre for Applied Bioanthropology, Institut za antropologiju, Zagreb, Croatia"}]},{"given":"Brecht","family":"Devleesschauwer","sequence":"additional","affiliation":[{"name":"Epidemiology and Public Health, Sciensano, Brussels, Belgium"},{"name":"Department of Veterinary Public Health and Food Safety, Ghent University Faculty of Veterinary Medicine, Merelbeke, Belgium"}]},{"given":"Paula Andrea","family":"Diaz Valencia","sequence":"additional","affiliation":[{"name":"Epidemiology Group, National College of Public Health, University of Antioquia, Medellin, Colombia"}]},{"given":"Jo\u00e3o C.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Centro de Biotecnologia e Qu\u00edmica Fina (CBQF), Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Porto, Portugal"}]},{"given":"Enrique Javier","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Center for Biomedical Technology, Universidad Polit\u00e9cnica de Madrid, Madrid, Spain"},{"name":"Biomedical Engineering and Telemedicine Centre, Universidad Polit\u00e9cnica de Madrid, Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain"}]},{"given":"Paul","family":"Hynds","sequence":"additional","affiliation":[{"name":"Environmental Sustainability and Health Institute, Technological University Dublin, Dublin, Ireland"}]},{"given":"Zubair","family":"Kabir","sequence":"additional","affiliation":[{"name":"School of Public Health, University College Cork, Cork, Ireland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1803-4167","authenticated-orcid":false,"given":"J\u00f6rn","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Nursing and Health Sciences, University of South-Eastern Norway, Kongsberg, Norway"}]},{"given":"Polychronis","family":"Kostoulas","sequence":"additional","affiliation":[{"name":"Faculty of Public Health, University of Thessaly, Volos, Greece"}]},{"given":"Luc\u00eda","family":"Llanos Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, Instituto de Investigacion Sanitaria de la Fundacion Jimenez Diaz, Madrid, Spain"}]},{"given":"Lucia Maria","family":"Lotrean","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania"}]},{"given":"Marek","family":"Majdan","sequence":"additional","affiliation":[{"name":"Institute for Global Health and Epidemiology, Trnava University in Trnava, Trnava, Slovakia"}]},{"given":"Ernestina","family":"Menasalvas","sequence":"additional","affiliation":[{"name":"Biomedical Engineering and Telemedicine Centre, Universidad Polit\u00e9cnica de Madrid, Madrid, Spain"}]},{"given":"Paul","family":"Nguewa","sequence":"additional","affiliation":[{"name":"Instituto de Salud Tropical (ISTUN), Department of Microbiology and Parasitology, Navarra Institute for Health Research (IdiSNA), Universidad de Navarra, Pamplona, Spain"}]},{"given":"In-Hwan","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Kyung Hee University, Seoul, Korea (the Republic of)"}]},{"given":"Georgie","family":"O\u2019Sullivan","sequence":"additional","affiliation":[{"name":"School of Public Health, University College Cork, Cork, Ireland"}]},{"given":"David M.","family":"Pereira","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Laborat\u00f3rio de Farmacognosia, Departamento de Qu\u00edmica, Faculdade de 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