{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:11:23Z","timestamp":1766268683521,"version":"build-2065373602"},"reference-count":45,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"unspecified","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Operational Program Social Inclusion and Employment","award":["(POISE-03-4639-FSE-000793)"],"award-info":[{"award-number":["(POISE-03-4639-FSE-000793)"]}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04750\/2020 and LA\/P\/0064\/2020"],"award-info":[{"award-number":["UIDB\/04750\/2020 and LA\/P\/0064\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","award":["(POISE-03-4639-FSE-000793)"],"award-info":[{"award-number":["(POISE-03-4639-FSE-000793)"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Portugal Inova\u00e7\u00e3o Social","award":["(POISE-03-4639-FSE-000793)"],"award-info":[{"award-number":["(POISE-03-4639-FSE-000793)"]}]},{"name":"Portugal 2020","award":["(POISE-03-4639-FSE-000793)"],"award-info":[{"award-number":["(POISE-03-4639-FSE-000793)"]}]},{"name":"Portuguese Stroke Society"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,3,30]]},"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Transient ischaemic attack (TIA) and minor stroke are frequently assumed as temporary or non-disabling events. However, evidence suggests that these patients can experience relevant impairment and functional disability. Therefore, the present study aims to evaluate the feasibility and effectiveness of a 3-month multidomain intervention programme, composed of five non-pharmacological strategies, aimed at accelerating return to pre-event level of functionality in patients with TIA or minor stroke.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>Patients diagnosed with a TIA or a minor stroke are being recruited at the emergency or neurology departments of the Hospital Pedro Hispano, located in Matosinhos, Portugal (n=70). Those who accept to participate will be randomly allocated to two groups (1:1): (a) Intervention\u2014receives a 3\u2009months combined approach, initiating early post-event, composed of cognitive training, physical exercise, nutrition, psychoeducation and assessment\/correction of hearing loss; (b) Control\u2014participants will not be subject to any intervention. Both groups will receive the usual standard of care provided to these diseases. Recruitment began in May 2022 and is expected to continue until March 2023. Socio-demographic characteristics, lifestyles, health status, cognitive function, symptoms of anxiety and depression and quality of life will be assessed; as well as anthropometry, blood pressure and physical condition. Time to complete or partial recovery of instrumental activities of daily living will be assessed using an adapted version of the Frenchay Activities Index. All participants will be evaluated before the intervention and after 3 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Ethics and dissemination<\/jats:title>\n                  <jats:p>This study was approved by the Ethics Committee of the Local Health Unit of Matosinhos (Ref. 75\/CES\/JAS). Written informed consent will be required from all the participants; data protection and confidentiality will be also ensured. The findings of this project are expected to be submitted for publication in scientific articles, and the main results will be presented at relevant scientific meetings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>\n                     <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT05369637\">NCT05369637<\/jats:ext-link>.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-069593","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T13:31:05Z","timestamp":1682688665000},"page":"e069593","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Study protocol for a pilot randomised controlled trial evaluating the feasibility and effectiveness of non-pharmacological interventions to recover functionality after a transient ischaemic attack or a minor stroke: the \u2018Back to Normal\u2019 trial"],"prefix":"10.1136","volume":"13","clinical-trial-number":[{"clinical-trial-number":"nct05369637","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct05383443","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6784-4871","authenticated-orcid":false,"given":"Micaela","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"EPIUnit, Instituto de Sa\u00fade P\u00fablica da Universidade do Porto, Porto, Portugal"},{"name":"Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR), Porto, Portugal"}]},{"given":"Maria Jo\u00e3o","family":"Lima","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Neurologia, Unidade Local de Sa\u00fade de Matosinhos EPE, Matosinhos, Portugal"}]},{"given":"\u00c2ngelo","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Neurologia, Unidade Local de Sa\u00fade de Matosinhos EPE, Matosinhos, Portugal"}]},{"given":"Cristina","family":"Duque","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Neurologia, Unidade Local de Sa\u00fade de Matosinhos EPE, Matosinhos, Portugal"}]},{"given":"Ana Rute","family":"Costa","sequence":"additional","affiliation":[{"name":"EPIUnit, Instituto de Sa\u00fade P\u00fablica da Universidade do Porto, Porto, Portugal"},{"name":"Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR), Porto, Portugal"},{"name":"Departamento de Ci\u00eancias da Sa\u00fade P\u00fablica e Forenses e Educa\u00e7\u00e3o M\u00e9dica, Faculdade de Medicina da Universidade do Porto, Porto, Portugal"}]},{"given":"Vitor Tedim","family":"Cruz","sequence":"additional","affiliation":[{"name":"EPIUnit, Instituto de Sa\u00fade 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