{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T19:43:13Z","timestamp":1765741393431,"version":"3.48.0"},"reference-count":18,"publisher":"BMJ","issue":"7","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"unspecified","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,5,30]]},"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Dermoscopy has a proved validity in the diagnosis of cutaneous melanoma, which is one of the most aggressive forms of skin cancer. Although some studies have demonstrated a relationship between specific dermoscopic and pathologic melanoma features, there is no solid evidence allowing reliable conclusions. This study will evaluate the evidence regarding this association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>Observational studies eligible for our systematic review will enrol adults with histological cutaneous non-volar melanoma diagnosis and with dermoscopy image analysis. We will search the following databases: PubMed, Embase, Web of Science, MEDLINE and Cochrane Library. We will not impose any language or date restrictions. Outcomes of interest include the association of at least one of the melanoma dermoscopy features (irregular pigmentation, blue-white veil, atypical network, multicomponent pattern, atypical dots and\/or globules, regression, peripheral tan structureless area, negative network, shiny white structures, atypical vessels and streaks\/pseudopods), with melanoma Breslow index or other histopathology characteristics (melanoma subtype, mitotic index and presence of ulceration). Two reviewers will independently screen and search results, extract data from eligible studies and assess risk of bias. The evidence derived by this study will elucidate the possible link between melanoma dermoscopy and histopathology. If we could predict melanoma thickness based on dermoscopy, we would be able to anticipate melanoma treatment with impact on survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Ethical approval is not required because this is a literature-based study. It will be published in scientific Pubmed indexed open access journals to ensure its accessibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD42024564919.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-090781","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T16:30:52Z","timestamp":1752510652000},"page":"e090781","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Cutaneous non-volar melanoma dermoscopy and histopathology correlation: a systematic review protocol"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5034-3613","authenticated-orcid":false,"given":"Rita","family":"Bouceiro Mendes","sequence":"first","affiliation":[{"name":"Dermatology, Leiria Region Local Health Unit, Leiria, Portugal"},{"name":"Health Sciences, Universidade da Beira Interior, Covilha, Portugal"}]},{"given":"Martinha","family":"Henrique","sequence":"additional","affiliation":[{"name":"Dermatology, Leiria Region Local Health Unit, Leiria, Portugal"}]},{"given":"Pedro","family":"Augusto-Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Health Sciences, Universidade da Beira Interior, Covilha, Portugal"}]},{"given":"Giuseppe","family":"Argenziano","sequence":"additional","affiliation":[{"name":"Dermatology, University of Campania Luigi Vanvitelli School of Medicine and Surgery, Naples, Italy"}]}],"member":"239","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"2025121411415843000_15.7.e090781.1","first-page":"1071","article-title":"Cutaneous melanoma: From pathogenesis to therapy (Review)","volume":"52","author":"Leonardi","year":"2018","journal-title":"Int J Oncol"},{"key":"2025121411415843000_15.7.e090781.2","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukaryotGeneExpr.2020028454"},{"key":"2025121411415843000_15.7.e090781.3","doi-asserted-by":"crossref","DOI":"10.3390\/cells10092320","article-title":"Molecular Markers and Targets in Melanoma","volume":"10","author":"Teixido","year":"2021","journal-title":"Cells"},{"key":"2025121411415843000_15.7.e090781.4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222212456"},{"key":"2025121411415843000_15.7.e090781.5","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1001\/jamadermatol.2021.2845","article-title":"Assessment of Diagnostic Accuracy of Dermoscopic Structures and Patterns Used in Melanoma Detection: A Systematic Review and Meta-analysis","volume":"157","author":"Williams","year":"2021","journal-title":"JAMA Dermatol"},{"key":"2025121411415843000_15.7.e090781.6","doi-asserted-by":"crossref","DOI":"10.3390\/genes12081288","article-title":"Dermoscopic Criteria, Histopathological Correlates and Genetic Findings of Thin Melanoma on Non-Volar Skin","volume":"12","author":"Massone","year":"2021","journal-title":"Genes (Basel)"},{"key":"2025121411415843000_15.7.e090781.7","first-page":"412","article-title":"Differentiating malignant melanoma from other lesions using dermoscopy","volume":"65","author":"Gniadecki","year":"2019","journal-title":"Can Fam Physician"},{"key":"2025121411415843000_15.7.e090781.8","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.281"},{"key":"2025121411415843000_15.7.e090781.9","first-page":"380","article-title":"Dermoscopy: A Review of the Structures That Facilitate Melanoma Detection","volume":"119","author":"Marghoob","year":"2019","journal-title":"J Am Osteopath Assoc"},{"key":"2025121411415843000_15.7.e090781.10","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/1346-8138.13629","article-title":"Dermoscopy pathology correlation in melanoma","volume":"44","author":"Russo","year":"2017","journal-title":"J Dermatol"},{"key":"2025121411415843000_15.7.e090781.11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174871","article-title":"Dermoscopic characteristics of melanoma according to the criteria \u201culceration\u201d and \u201cmitotic rate\u201d of the AJCC 2009 staging system for melanoma","volume":"12","author":"Deinlein","year":"2017","journal-title":"PLoS ONE"},{"key":"2025121411415843000_15.7.e090781.12","first-page":"470","article-title":"Dermoscopy and its role in diagnosing melanocytic lesions: a guide for pathologists","volume":"36","author":"Crotty","year":"2004","journal-title":"Pathology (Phila)"},{"key":"2025121411415843000_15.7.e090781.13","doi-asserted-by":"crossref","DOI":"10.5826\/dpc.1102a40","article-title":"Dermoscopic Features as Predictors of BRAF Mutational Status and Sentinel Lymph Node Positivity in Primary Cutaneous Melanoma","volume":"11","author":"Filipovi\u0107","year":"2021","journal-title":"Dermatol Pract Concept"},{"key":"2025121411415843000_15.7.e090781.14","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"2025121411415843000_15.7.e090781.15","doi-asserted-by":"publisher","DOI":"10.7326\/M18-1376"},{"key":"2025121411415843000_15.7.e090781.16","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000571"},{"key":"2025121411415843000_15.7.e090781.17","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00403-021-02226-x","article-title":"Dermoscopy of early melanomas: variation according to the anatomic site","volume":"314","author":"Tognetti","year":"2022","journal-title":"Arch Dermatol Res"},{"key":"2025121411415843000_15.7.e090781.18","unstructured":"Sch\u00fcnemann H , Bro\u017cek J , Guyatt G , et al ., eds. GRADE Handbook.2013. Available: https:\/\/gdt.gradepro.org\/app\/handbook\/handbook.html"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2024-090781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T19:42:04Z","timestamp":1765741324000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2024-090781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":18,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7,8]]},"published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1136\/bmjopen-2024-090781"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2024-090781","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"type":"print","value":"2044-6055"},{"type":"electronic","value":"2044-6055"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}