{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T06:13:23Z","timestamp":1776492803108,"version":"3.51.2"},"reference-count":42,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"unspecified","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Foundation for Science and Technology-FCT (Portuguese Ministry of Science, Technology and Higher Education) PhD Studentship","award":["2022.14189.BD"],"award-info":[{"award-number":["2022.14189.BD"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,11,27]]},"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Pre-eclampsia is a pregnancy-related complication estimated to affect up to 8% of pregnancies worldwide. It is associated with an increased risk of postpartum sustained hypertension, coronary artery disease, cerebrovascular disease, peripheral arterial disease and cardiovascular-related mortality. Nevertheless, these associations have seldom been addressed in younger women from sub-Saharan Africa (SSA). Hence, this study aims to assess the association between pre-eclampsia and cardiovascular impairment within the first year after delivery, among younger women in SSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This is a prospective cohort study conducted at Hospital Nacional Sim\u00e3o Mendes in Bissau, Guinea-Bissau. A total of 230 pregnant women aged below 25 years (115 diagnosed with pre-eclampsia and 115 normotensive age-matched pregnancies), will be enrolled after their 20th gestational week. Exclusion criteria include diabetes, hypertension or other serious maternal diseases present before pregnancy. Participants will be assessed at baseline (pre-labour period), 4 and 12 months after delivery; evaluations started in March 2023 and are expected to end in December 2026. At each follow-up assessment, the women will have their blood pressure measured with a digital sphygmomanometer and a 24-hour ambulatory blood pressure monitor. Cardiac and renal function will be assessed using echocardiography and laboratory testing, respectively. Primary outcomes include the mean differences in cardiovascular and renal parameters between women who had pre-eclampsia and those who had normotensive pregnancies. Age, parity, age at first pregnancy, family history of cardiovascular diseases, smoking habits, gestational diabetes diagnosed before pre-eclampsia, body mass index and labour complications will be considered a priori as potential confounders of the association between pre-eclampsia and postpartum cardiovascular impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This study was approved by the Comit\u00e9 Nacional de \u00c9tica em Pesquisa na Sa\u00fade, Guinea-Bissau (008\/CNES\/INASA\/2023), and participants provide written informed consent. Results will be disseminated among the scientific community and the public.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-091882","type":"journal-article","created":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T05:53:40Z","timestamp":1734760420000},"page":"e091882","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Pre-eclampsia as a predictor of early-onset cardiovascular impairment among young women (PREECARDIA study): protocol for a prospective cohort study"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1452-1128","authenticated-orcid":false,"given":"Ruben","family":"Tur\u00e9","sequence":"first","affiliation":[{"name":"EPIunit and Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR), Universidade do Porto Instituto de Saude Publica, Porto, Portugal"},{"name":"Hospital Nacional Sim\u00e3o Mendes, Bissau, Guinea-Bissau"}]},{"given":"Albertino","family":"Damasceno","sequence":"additional","affiliation":[{"name":"EPIunit and Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR), Universidade do Porto Instituto de Saude Publica, Porto, Portugal"},{"name":"University of Eduardo Mondlane Faculty of Medicine, Maputo, Mozambique"}]},{"given":"Amabelia","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Bandim Health Project, Bissau, Guinea-Bissau"},{"name":"Minist\u00e9rio de Sa\u00fade P\u00fablica, Bissau, Guinea-Bissau"}]},{"given":"Eunice","family":"Barai","sequence":"additional","affiliation":[{"name":"Hospital Nacional Sim\u00e3o Mendes, Bissau, Guinea-Bissau"}]},{"given":"Almame","family":"Ciss\u00e9","sequence":"additional","affiliation":[{"name":"Hospital Nacional Sim\u00e3o Mendes, Bissau, Guinea-Bissau"}]},{"given":"Gabriel","family":"Sanca","sequence":"additional","affiliation":[{"name":"Cooperativa M\u00e9dico Sanit\u00e1ria Madrugada de Bissau, Bissau, Guinea-Bissau"}]},{"given":"Tida","family":"Iafa","sequence":"additional","affiliation":[{"name":"Hospital Nacional Sim\u00e3o Mendes, Bissau, Guinea-Bissau"}]},{"given":"Waldir","family":"Jalo","sequence":"additional","affiliation":[{"name":"Hospital Nacional Sim\u00e3o Mendes, Bissau, Guinea-Bissau"}]},{"given":"Bubacar","family":"Embalo","sequence":"additional","affiliation":[{"name":"Hospital Nacional Sim\u00e3o Mendes, Bissau, Guinea-Bissau"}]},{"given":"Marcos","family":"Dju","sequence":"additional","affiliation":[{"name":"Hospital Nacional Sim\u00e3o Mendes, Bissau, Guinea-Bissau"}]},{"given":"Vasco","family":"Iala","sequence":"additional","affiliation":[{"name":"Hospital Militar, Bissau, Guinea-Bissau"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1870-1430","authenticated-orcid":false,"given":"Nuno","family":"Lunet","sequence":"additional","affiliation":[{"name":"EPIunit and Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR), Universidade do Porto Instituto de Saude Publica, Porto, Portugal"},{"name":"Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal"}]}],"member":"239","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"2025121515292438000_14.12.e091882.1","unstructured":"World Health Organization . 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