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By enrolling women with and without pre-eclampsia (PE), alongside their partners and infants, the study aims to identify the genetic and molecular determinants of PE. This update summarises the final dataset, reviews key findings since the 2016 cohort profile, and outlines current research directions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>FINNPEC is a multicentre, cross-sectional case\u2013control cohort collected across five Finnish university hospitals. The final cohort comprises 2810 women (1654 PE cases and 1156 controls), with comprehensive biological samples and clinical data collected from their children and the children\u2019s fathers.<\/jats:p>\n                    <jats:p>A longitudinal subgroup\u2014the FINNCARE study\u2014enrolled 192 families with prior PE and 92 control families between 2019 and 2022. This subgroup underwent cardiovascular risk profiling and participated in a randomised controlled trial evaluating a 12-month lifestyle intervention to mitigate cardiovascular disease (CVD) risk 8\u201312 years postpartum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings to date<\/jats:title>\n                    <jats:p>Research within FINNPEC has provided novel insights into maternal and fetal genetic susceptibility, revealing a shared genetic architecture between PE, blood pressure regulation and CVD. Studies have also advanced our understanding of the role of angiogenic imbalance, metabolic alterations and non-traditional risk factors in the pathogenesis of PE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future plans<\/jats:title>\n                    <jats:p>The current aim is to understand the complex, long-term association of PE and CVD within families. Ongoing studies focus on (1) risk stratification using registry data to classify CVD risk in women with prior PE; (2) assessing how genetic susceptibility to PE and CVD predicts pregnancy outcomes and later-life cardiovascular health; and (3) exploring how paternal and fetal genetics influence maternal PE risk and subsequent CVD morbidity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2026-122347","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:03:03Z","timestamp":1790694183000},"page":"e122347","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Cohort profile update: the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC)"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1202-0936","authenticated-orcid":false,"given":"Tiina J","family":"J\u00e4\u00e4skel\u00e4inen","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition, University of Helsinki, Helsinki, Finland"},{"name":"Department of Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4979-998X","authenticated-orcid":false,"given":"Anni","family":"Kivel\u00e4","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4397-8415","authenticated-orcid":false,"given":"A. Inkeri","family":"Lokki","sequence":"additional","affiliation":[{"name":"Heart and Lung Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"},{"name":"Department of Bacteriology and Immunology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tea","family":"Kaartokallio","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eija","family":"Kortelainen","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"},{"name":"Department of Obstetrics and Gynaecology, Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4757-6563","authenticated-orcid":false,"given":"Jaakko","family":"Tyrmi","sequence":"additional","affiliation":[{"name":"Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, University of Tampere, Tampere, Pirkanmaa, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7530-6918","authenticated-orcid":false,"given":"Jaakko","family":"Leinonen","sequence":"additional","affiliation":[{"name":"Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, University of Tampere, Tampere, Pirkanmaa, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eero","family":"Kajantie","sequence":"additional","affiliation":[{"name":"Population Health Unit, Finnish Institute for Health and Welfare, Helsinki and Oulu, Finland"},{"name":"PEDEGO Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland"},{"name":"Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"},{"name":"Department of Clinical and Molecular Medicine, Norwegian University of Health and Technology, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1974-0271","authenticated-orcid":false,"given":"Juha","family":"Kere","sequence":"additional","affiliation":[{"name":"Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden"},{"name":"Stem Cells and Metabolism Research Program (STEMM), University of Helsinki, Helsinki, Finland"},{"name":"Folkh\u00e4lsan Research Center, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1135-7625","authenticated-orcid":false,"given":"Katja","family":"Kivinen","sequence":"additional","affiliation":[{"name":"Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland"},{"name":"Faculty of Pharmacy, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0383-1972","authenticated-orcid":false,"given":"Anneli","family":"Pouta","sequence":"additional","affiliation":[{"name":"Department of Safety, National Institute for Health and Welfare, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5949-0874","authenticated-orcid":false,"given":"Seppo","family":"Heinonen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3212-7826","authenticated-orcid":false,"given":"Hannele","family":"Laivuori","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"},{"name":"Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, University of Tampere, Tampere, Pirkanmaa, Finland"},{"name":"Department of Obstetrics and Gynecology, Tampere University Hospital, The Wellbeing Services County of Pirkanmaa, Tampere, Finland"},{"name":"Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"2026092908002370000_16.9.e122347.1","doi-asserted-by":"crossref","unstructured":"Chappell LC , Cluver CA , Kingdom J , et al . 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