{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T20:33:04Z","timestamp":1775680384478,"version":"3.50.1"},"reference-count":58,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Gut"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Artificial intelligence (AI) may reduce underdiagnosed or overlooked upper GI (UGI) neoplastic and preneoplastic conditions, due to subtle appearance and low disease prevalence. Only disease-specific AI performances have been reported, generating uncertainty on its clinical value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>We searched PubMed, Embase and Scopus until July 2020, for studies on the diagnostic performance of AI in detection and characterisation of UGI lesions. Primary outcomes were pooled diagnostic accuracy, sensitivity and specificity of AI. Secondary outcomes were pooled positive (PPV) and negative (NPV) predictive values. We calculated pooled proportion rates (%), designed summary receiving operating characteristic curves with respective area under the curves (AUCs) and performed metaregression and sensitivity analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 19 studies on detection of oesophageal squamous cell neoplasia (ESCN) or Barrett's esophagus-related neoplasia (BERN) or gastric adenocarcinoma (GCA) were included with 218, 445, 453 patients and 7976, 2340, 13\u2009562 images, respectively. AI-sensitivity\/specificity\/PPV\/NPV\/positive likelihood ratio\/negative likelihood ratio for UGI neoplasia detection were 90% (CI 85% to 94%)\/89% (CI 85% to 92%)\/87% (CI 83% to 91%)\/91% (CI 87% to 94%)\/8.2 (CI 5.7 to 11.7)\/0.111 (CI 0.071 to 0.175), respectively, with an overall AUC of 0.95 (CI 0.93 to 0.97). No difference in AI performance across ESCN, BERN and GCA was found, AUC being 0.94 (CI 0.52 to 0.99), 0.96 (CI 0.95 to 0.98), 0.93 (CI 0.83 to 0.99), respectively. Overall, study quality was low, with high risk of selection bias. No significant publication bias was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found a high overall AI accuracy for the diagnosis of any neoplastic lesion of the UGI tract that was independent of the underlying condition. This may be expected to substantially reduce the miss rate of precancerous lesions and early cancer when implemented in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1136\/gutjnl-2020-321922","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T21:21:08Z","timestamp":1604092868000},"page":"1458-1468","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":59,"title":["Standalone performance of artificial intelligence for upper GI neoplasia: a meta-analysis"],"prefix":"10.1136","volume":"70","author":[{"given":"Julia","family":"Arribas","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1797-3864","authenticated-orcid":false,"given":"Giulio","family":"Antonelli","sequence":"additional","affiliation":[]},{"given":"Leonardo","family":"Frazzoni","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8618-2447","authenticated-orcid":false,"given":"Lorenzo","family":"Fuccio","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7765-035X","authenticated-orcid":false,"given":"Alanna","family":"Ebigbo","sequence":"additional","affiliation":[]},{"given":"Fons","family":"van der Sommen","sequence":"additional","affiliation":[]},{"given":"Noha","family":"Ghatwary","sequence":"additional","affiliation":[]},{"given":"Christoph","family":"Palm","sequence":"additional","affiliation":[]},{"given":"Miguel","family":"Coimbra","sequence":"additional","affiliation":[]},{"given":"Francesco","family":"Renna","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7548-6955","authenticated-orcid":false,"given":"J J G H M","family":"Bergman","sequence":"additional","affiliation":[]},{"given":"Prateek","family":"Sharma","sequence":"additional","affiliation":[]},{"given":"Helmut","family":"Messmann","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7167-1459","authenticated-orcid":false,"given":"Cesare","family":"Hassan","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0121-6850","authenticated-orcid":false,"given":"Mario J","family":"Dinis-Ribeiro","sequence":"additional","affiliation":[]}],"member":"239","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"key":"2022012403100967000_70.8.1458.1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.02.068"},{"key":"2022012403100967000_70.8.1458.2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1053\/j.gastro.2018.04.026","article-title":"Endoscopic screening in Asian countries is associated with reduced gastric cancer mortality: a meta-analysis and systematic review","volume":"155","author":"Zhang","year":"2018","journal-title":"Gastroenterology"},{"key":"2022012403100967000_70.8.1458.3","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1055\/a-1104-5245","article-title":"Role of gastrointestinal endoscopy in the screening of digestive tract cancers in Europe: European Society of gastrointestinal endoscopy (ESGE) position statement","volume":"52","author":"S\u0103ftoiu","year":"2020","journal-title":"Endoscopy"},{"key":"2022012403100967000_70.8.1458.4","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1177\/2050640617722902","article-title":"Endoscopic screening for gastric cancer: a cost-utility analysis for countries with an intermediate gastric cancer risk","volume":"6","author":"Areia","year":"2018","journal-title":"United European Gastroenterol J"},{"key":"2022012403100967000_70.8.1458.5","doi-asserted-by":"crossref","first-page":"E46","DOI":"10.1055\/s-0034-1365524","article-title":"How commonly is upper gastrointestinal cancer missed at endoscopy? 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