{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T01:45:43Z","timestamp":1769737543232,"version":"3.49.0"},"reference-count":34,"publisher":"BMJ","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2011,7,30]]},"published-print":{"date-parts":[[2011,12,15]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Chronic right ventricular (RV) pacing is associated with deleterious effects on cardiac function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>In an observational multicentre study in children with isolated atrioventricular (AV) block receiving chronic ventricular pacing, the importance of the ventricular pacing site on left ventricular (LV) function was investigated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Demographics, maternal autoantibody status and echocardiographic measurements on LV end-diastolic and end-systolic dimensions and volumes at age &lt;18\u2005years were retrospectively collected from patients undergoing chronic ventricular pacing (&gt;1\u2005year) for isolated AV block. LV fractional shortening (LVFS) and, if possible LV ejection fraction (LVEF) were calculated. Linear regression analyses were adjusted for patient characteristics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>From 27 centres, 297 children were included, in whom pacing was applied at the RV epicardium (RVepi, n=147), RV endocardium (RVendo, n=113) or LV epicardium (LVepi, n=37). LVFS was significantly affected by pacing site (p=0.001), and not by maternal autoantibody status (p=0.266). LVFS in LVepi (39\u00b15%) was significantly higher than in RVendo (33\u00b17%, p&lt;0.001) and RVepi (35\u00b18%, p=0.001; no significant difference between RV-paced groups, p=0.275). Subnormal LVFS (LVFS&lt;28%) was seen in 16\/113 (14%) RVendo-paced and 21\/147 (14%) RVepi-paced children, while LVFS was normal (LVFS\u226528%) in all LVepi-paced children (p=0.049). These results are supported by the findings for LVEF (n=122): LVEF was &lt;50% in 17\/69 (25%) RVendo- and in 10\/35 (29%) RVepi-paced patients, while LVEF was \u226550% in 17\/18 (94%) LVepi-paced patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In children with isolated AV block, permanent ventricular pacing site is an important determinant of LV function, with LVFS being significantly higher with LV pacing than with RV pacing.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heartjnl-2011-300197","type":"journal-article","created":{"date-parts":[[2011,9,15]],"date-time":"2011-09-15T03:40:49Z","timestamp":1316058049000},"page":"2051-2055","source":"Crossref","is-referenced-by-count":63,"title":["Impact of the permanent ventricular pacing site on left ventricular function in children: a retrospective multicentre survey"],"prefix":"10.1136","volume":"97","author":[{"given":"Irene E","family":"van Geldorp","sequence":"first","affiliation":[]},{"given":"Tammo","family":"Delhaas","sequence":"additional","affiliation":[]},{"given":"Roman A","family":"Gebauer","sequence":"additional","affiliation":[]},{"given":"Patrick","family":"Frias","sequence":"additional","affiliation":[]},{"given":"Maren","family":"Tomaske","sequence":"additional","affiliation":[]},{"given":"Mark K","family":"Friedberg","sequence":"additional","affiliation":[]},{"given":"Svjetlana","family":"Tisma-Dupanovic","sequence":"additional","affiliation":[]},{"given":"Jan","family":"Elders","sequence":"additional","affiliation":[]},{"given":"Andreas","family":"Fr\u00fch","sequence":"additional","affiliation":[]},{"given":"Fulvio","family":"Gabbarini","sequence":"additional","affiliation":[]},{"given":"Petr","family":"Kubu\u0161","sequence":"additional","affiliation":[]},{"given":"Viera","family":"Illikova","sequence":"additional","affiliation":[]},{"given":"Sabrina","family":"Tsao","sequence":"additional","affiliation":[]},{"given":"Andreas 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