{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T16:02:28Z","timestamp":1771603348971,"version":"3.50.1"},"reference-count":19,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[2013,10,3]]},"published-print":{"date-parts":[[2014,1,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To analyse the main characteristics, associated conditions and outcome of right aortic arch (RAA) detected in fetal life, and to assess if further investigation is required in cases of isolated RAA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Retrospective observational study of all fetuses diagnosed with a RAA between 2004 and 2012 at a tertiary centre for fetal cardiology.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A RAA was identified in 98 fetuses: 27 had normal intracardiac anatomy and 71 were associated with other congenital heart disease (CHD); conotruncal anomalies being the most common. An aberrant left subclavian artery was diagnosed in 18.4% of cases, a double aortic arch in 6.1%, and 12.2% had a vascular ring confirmed after birth. Overall, an extracardiac anomaly was present in 31.6% of the patients and a chromosomal anomaly in 15.3%, with half of the latter cases being 22q11.2 microdeletion. Extracardiac and chromosomal anomalies were more commonly associated with RAA with structural CHD (39.4% and 19.7%, respectively), compared to cases of RAA with normal intracardiac anatomy (11.1% and 3.7%, respectively) (p&lt;0.05). First year mortality was 10.3%, with all deaths being in cases with associated structural CHD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Detailed fetal extracardiac examination should be undertaken in all cases of RAA. Isolated RAA has a good prognosis, and in the majority of the patients it is an asymptomatic vascular variant with a relatively low risk for chromosomal anomaly. The prognosis of RAA with CHD depends on the complexity of the CHD and\/or the associated extracardiac anomalies. In these cases, there is a higher risk for chromosomal anomaly, particularly 22q11.2 microdeletion.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heartjnl-2013-304860","type":"journal-article","created":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T22:37:52Z","timestamp":1383691072000},"page":"54-59","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":61,"title":["Right aortic arch diagnosed antenatally: associations and outcome in 98 fetuses"],"prefix":"10.1136","volume":"100","author":[{"given":"Joana O","family":"Miranda","sequence":"first","affiliation":[{"name":"Fetal Cardiology Unit, Evelina London Children's Hospital, London, UK"},{"name":"Paediatric Cardiology Department, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Nicky","family":"Callaghan","sequence":"additional","affiliation":[{"name":"Fetal Cardiology Unit, Evelina London Children's Hospital, London, UK"}]},{"given":"Owen","family":"Miller","sequence":"additional","affiliation":[{"name":"Fetal Cardiology Unit, Evelina London Children's Hospital, London, UK"}]},{"given":"John","family":"Simpson","sequence":"additional","affiliation":[{"name":"Fetal Cardiology Unit, Evelina London Children's Hospital, London, UK"}]},{"given":"Gurleen","family":"Sharland","sequence":"additional","affiliation":[{"name":"Fetal Cardiology Unit, Evelina London Children's Hospital, London, UK"}]}],"member":"239","published-online":{"date-parts":[[2013,11,5]]},"reference":[{"key":"2025092101075662000_100.1.54.1","doi-asserted-by":"crossref","unstructured":"Yoo SJ Bradley T Jaeggi E . Fetal cardiology: embryology, genetics, physiology, echocardiographic evaluation, diagnosis and perinatal management of cardiac diseases. Aortic arch anomalies. In: Yagel S Silverman NH Gembruch U , eds. Aortic arch anomalies. 2nd edn. New York: Informa Healthcare USA, Inc, 2009:329\u201342.","DOI":"10.3109\/9781439807989.022"},{"key":"2025092101075662000_100.1.54.2","unstructured":"Sharland G . Fetal cardiology simplified: a practical manual. In: Sharland G , eds. UK: TFM Publishing Ltd, 2013:256\u201360."},{"key":"2025092101075662000_100.1.54.3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00850.x"},{"key":"2025092101075662000_100.1.54.4","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3883"},{"key":"2025092101075662000_100.1.54.5","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3841"},{"key":"2025092101075662000_100.1.54.6","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2327"},{"key":"2025092101075662000_100.1.54.7","unstructured":"Weinberg PM . Moss and adams\u2019 heart disease in infants, children, and adolescents: including the fetus and young adults. In: Allen HD Driscoll DJ Shaddy RE Feltes TF , eds. Aortic arch anomalies. 7th edn. Philadelphia: Lippincott Williams & Wilkins, 2008:731\u201360."},{"key":"2025092101075662000_100.1.54.8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s002460010231","article-title":"Patterns of right aortic arch and mirror-image branching of the brachiocephalic vessels without associated anomalies","volume":"22","author":"McElhinney","year":"2001","journal-title":"Pediatr Cardiol"},{"key":"2025092101075662000_100.1.54.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(05)80534-3"},{"key":"2025092101075662000_100.1.54.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01286-4"},{"key":"2025092101075662000_100.1.54.11","doi-asserted-by":"publisher","DOI":"10.1007\/s002469900414"},{"key":"2025092101075662000_100.1.54.12","first-page":"642","article-title":"Laterality of the aortic arch and anomalies of the subclavian artery\u2014reliable indicators for 22q11.2 deletion syndromes?","volume":"163","author":"Rauch","year":"2004","journal-title":"Eur J Pediatr"},{"key":"2025092101075662000_100.1.54.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.01.333"},{"key":"2025092101075662000_100.1.54.14","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2677"},{"key":"2025092101075662000_100.1.54.15","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00801.x"},{"key":"2025092101075662000_100.1.54.16","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.6.e472"},{"key":"2025092101075662000_100.1.54.17","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-003-0441-3"},{"key":"2025092101075662000_100.1.54.18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00864.x"},{"key":"2025092101075662000_100.1.54.19","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/s00431-007-0645-2","article-title":"Chromosome 22q11.2 microdeletion in children with conotruncal heart defects: frequency, associated cardiovascular anomalies, and outcome following cardiac surgery","volume":"67","author":"Ziolkowska","year":"2008","journal-title":"Eur J Pediatr"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/heartjnl-2013-304860","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T08:08:08Z","timestamp":1758442088000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/heartjnl-2013-304860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,5]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,12,6]]},"published-print":{"date-parts":[[2014,1,1]]}},"alternative-id":["10.1136\/heartjnl-2013-304860"],"URL":"https:\/\/doi.org\/10.1136\/heartjnl-2013-304860","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,5]]}}}