{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T07:00:03Z","timestamp":1779001203837,"version":"3.51.4"},"reference-count":30,"publisher":"BMJ","issue":"22","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[2014,6,11]]},"published-print":{"date-parts":[[2014,11,15]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Prealbumin is one of the best indicators of nutritional status. We previously showed that prealbumin predicted in-hospital mortality in heart failure (HF) patients. We evaluated if a low discharge prealbumin after admission with acute HF would predict morbidity and mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a prospective observational study. Patients admitted with a primary diagnosis of HF were studied. Follow-up was up to 6\u2005months. Endpoints analysed were: all-cause and HF-death; all-cause and worsening HF hospitalisation. Patients with discharge prealbumin \u226415.0\u2005mg\/dL and those with prealbumin &gt;15\u2005mg\/dL were compared. A Cox-regression analysis was used to evaluate the prognostic impact of low prealbumin.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We studied 514 patients. Mean age was 78\u2005years and 45.7% were male. During follow-up, 101 patients died (78 for HF) and 209 patients were hospital readmitted (140 for worsening HF). Median prealbumin was 20.1 (15.3\u201325.3) mg\/dL. Patients with lower prealbumin were more often women, older aged and with non-ischaemic HF; they had lower albumin, haemoglobin and total cholesterol; and higher glomerular filtration rate, C-reactive protein, B-type natriuretic peptide and length of hospital stay. Lower prealbumin associated with less \u03b2-blocker and statin use. Patients with discharge prealbumin \u226415\u2005mg\/dL had a multivariate adjusted HR of 6-month all-cause and HF death of 1.67 (1.00 to 2.80) and 2.12 (1.19 to 3.79) respectively and of all-cause and HF readmission of 1.47 (1.01 to 2.14) and 1.58 (1.01 to 2.47).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Patients with discharge prealbumin \u226415\u2005mg\/dL have an higher risk of 6\u2005months morbidity and mortality. The unbalance between protein\u2013energy demands and its availability predicts ominous HF outcome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heartjnl-2014-305747","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T05:46:54Z","timestamp":1404280014000},"page":"1780-1785","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":63,"title":["Low prealbumin is strongly associated with adverse outcome in heart failure"],"prefix":"10.1136","volume":"100","author":[{"given":"Patr\u00edcia","family":"Louren\u00e7o","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Medicina Interna, Centro Hospitalar S\u00e3o Jo\u00e3o, Faculdade de Medicina da Universidade do Porto, Unidade I&D Cardiovascular do Porto, Porto, Portugal"}]},{"given":"S\u00e9rgio","family":"Silva","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Medicina Interna, Centro Hospitalar S\u00e3o Jo\u00e3o, Faculdade de Medicina da Universidade do Porto, Unidade I&D Cardiovascular do Porto, Porto, Portugal"}]},{"given":"Fernando","family":"Fri\u00f5es","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Medicina Interna, Centro Hospitalar S\u00e3o Jo\u00e3o, Faculdade de Medicina da Universidade do Porto, Unidade I&D Cardiovascular do Porto, Porto, Portugal"}]},{"given":"Margarida","family":"Alvelos","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Medicina Interna, Centro Hospitalar S\u00e3o Jo\u00e3o, Faculdade de Medicina da Universidade do Porto, Unidade I&D Cardiovascular do Porto, Porto, Portugal"}]},{"given":"Marta","family":"Amorim","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Medicina Interna, Centro Hospitalar S\u00e3o Jo\u00e3o, Faculdade de Medicina da Universidade do Porto, Unidade I&D Cardiovascular do Porto, Porto, Portugal"}]},{"given":"Marta","family":"Couto","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Medicina Interna, Centro Hospitalar S\u00e3o Jo\u00e3o, Faculdade de Medicina da Universidade do Porto, Unidade I&D Cardiovascular do Porto, Porto, Portugal"}]},{"given":"Paulo","family":"Torres-Ramalho","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Medicina Interna, Centro Hospitalar S\u00e3o Jo\u00e3o, Faculdade de Medicina da Universidade do Porto, Unidade I&D Cardiovascular do Porto, Porto, Portugal"}]},{"given":"Jo\u00e3o Tiago","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Patologia Cl\u00ednica, Centro Hospitalar S\u00e3o Jo\u00e3o, Faculdade de Medicina da Universidade do Porto, Porto, Portugal"},{"name":"Departamento de Bioqu\u00edmica, Faculdade de Medicina da Universidade do Porto, Porto, Portugal"}]},{"given":"Jos\u00e9 Paulo","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Medicina Interna, Centro Hospitalar S\u00e3o Jo\u00e3o, Faculdade de Medicina da Universidade do 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