{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:41:07Z","timestamp":1772109667923,"version":"3.50.1"},"reference-count":24,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[2017,8,5]]},"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To assess the prevalence of short corrected QT (QTc) intervals and its impact on short QT syndrome (SQTS) diagnosis using different QT correction formulae.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Observational study. The prevalence of short QTc intervals was estimated using four different QT correction formulae in 14\u2009662 young adults from the \u2018Sudden Cardiac Death Screening of Risk FactOrS\u2019 (SCD-SOS) cohort. Then, using data from this cohort and the pooled-cohort analysed by Gollob <jats:italic>et al<\/jats:italic>, comprising 61 patients with SQTS, we assessed the impact of the different QTc correction formulae on SQTS probability and diagnosis based on the Expert Consensus recommendations (QTc \u2264330 ms or QTc 330\u2013360 ms+1\u2009additional risk feature).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The prevalence of individuals with a QTc \u2264330\u2009and \u2264320\u2009ms in the SCD-SOS cohort was extremely low (\u22640.07%\u2009and\u22640.02%, respectively), and these were more frequently identified by the Framingham correction. The different QTc correction formulae led to a shift in SQTS probability in 5%\u201310% of individuals in both the SCD-SOS and Gollob cohort). Intermediate probability individuals were rare (&lt;0.1%), and no high-SQTS probability individuals were identified in the SCD-SOS cohort. Based on Consensus criteria, instead of 12 (0.08%) individuals being diagnosed with SQTS using the <jats:italic>Bazett<\/jats:italic> equation, a different number of individuals would meet diagnostic criteria with the other formulae: 11 (0.08%) using <jats:italic>Fridericia<\/jats:italic>, 9 (0.06%) with <jats:italic>Hodges<\/jats:italic> and 16 (0.11%) using the <jats:italic>Framingham<\/jats:italic> equation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Prevalence of SQTS in the apparently healthy adult population is low. Applying different QTc correction formulae leads to significant reclassification of SQTS probability and their impact on predicting outcomes should be assessed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heartjnl-2017-311673","type":"journal-article","created":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T20:55:24Z","timestamp":1506545724000},"page":"502-508","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Impact of QTc formulae in the prevalence of short corrected QT interval and impact on probability and diagnosis of short QT syndrome"],"prefix":"10.1136","volume":"104","clinical-trial-number":[{"clinical-trial-number":"nct01845909","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Rui","family":"Provid\u00eancia","sequence":"first","affiliation":[{"name":"Barts Heart Centre, Barts Health NHS Trust, London, UK"},{"name":"Farr Institute of Health Informatics, University College of London, London, UK"}]},{"given":"Nabeela","family":"Karim","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, Barts Health NHS Trust, London, UK"}]},{"given":"Neil","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, Barts Health NHS Trust, London, UK"}]},{"given":"Shohreh","family":"Honarbakhsh","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, Barts Health NHS Trust, London, UK"}]},{"given":"Maria Jo\u00e3o","family":"Vidigal Ferreira","sequence":"additional","affiliation":[{"name":"Centro Hospitalar e Universitario de Coimbra, Coimbra, Portugal"},{"name":"Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal"}]},{"given":"Lino","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Centro Hospitalar e Universitario de Coimbra, Coimbra, Portugal"},{"name":"Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal"}]},{"given":"Eloi","family":"Marijon","sequence":"additional","affiliation":[{"name":"Paris Cardiovascular Research Center (PARCC), INSERM Unit 970, Paris, France"},{"name":"AP-HP, Service de Cardiologie, H\u00f4pital Europ\u00e9en Georges Pompidou, Paris, France"}]},{"given":"Pier D","family":"Lambiase","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, Barts Health NHS Trust, London, UK"},{"name":"Institute of Cardiovascular Science, University College of London, London, UK"}]}],"member":"239","published-online":{"date-parts":[[2017,9,27]]},"reference":[{"key":"2025092014283692000_104.6.502.1","doi-asserted-by":"publisher","DOI":"10.1159\/000047299"},{"key":"2025092014283692000_104.6.502.2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2015-094827"},{"key":"2025092014283692000_104.6.502.3","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2012-092067"},{"key":"2025092014283692000_104.6.502.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.05.014"},{"key":"2025092014283692000_104.6.502.5","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp473"},{"key":"2025092014283692000_104.6.502.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.12.014"},{"key":"2025092014283692000_104.6.502.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.09.048"},{"key":"2025092014283692000_104.6.502.8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2002.01211.x"},{"key":"2025092014283692000_104.6.502.9","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90562-D"},{"key":"2025092014283692000_104.6.502.10","first-page":"694","article-title":"Bazett\u2019s 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