{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:44:21Z","timestamp":1772163861246,"version":"3.50.1"},"reference-count":25,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[2017,7,21]]},"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Coronary angiography is regularly performed in patients with worsening signs and\/or symptoms of heart failure (HF). However, little is known on the determinants, findings and associated clinical outcomes of coronary angiography performed in patients with worsening HF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The BIOSTAT-CHF (a systems BIOlogy Study to TAilored Treatment in Chronic Heart Failure) programme enrolled 2516 patients with worsening symptoms and\/or signs of HF, either hospitalised or in the outpatient setting. All patients were included in the present analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 2516 patients included, 315 (12.5%) underwent coronary angiography within the 30 days after the onset of worsening symptoms and\/or signs of HF. Subjects who underwent angiography were more often observed as inpatients, had more often an overt acute coronary syndrome, had higher troponin I levels, were younger and had better renal function (all p\u22640.01). Patients who underwent coronary angiography had a lower risk of the primary outcome of death and\/or HF hospitalisation (adjusted HR=0.71, 95% CI 0.57 to 0.89, p=0.003) and death (adjusted HR=0.59, 95% CI 0.43 to 0.80, p=0.001). Among the patients who underwent coronary angiography, those with a coronary stenosis (39%) had a worse prognosis than those without stenosis (adjusted HR for the primary outcome=1.71, 95% CI 1.10 to 2.64, p=0.016).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Coronary angiography was performed in &lt;13% of patients with symptoms and\/or signs of worsening HF. These patients were remarkably different from those who did not undergo coronary angiography and had a lower risk of subsequent events. The presence of coronary stenosis on coronary angiography was associated with a worse prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/heartjnl-2017-311750","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T20:40:25Z","timestamp":1502397625000},"page":"606-613","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Coronary angiography in worsening heart failure: determinants, findings and prognostic implications"],"prefix":"10.1136","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2304-6138","authenticated-orcid":false,"given":"Jo\u00e3o Pedro","family":"Ferreira","sequence":"first","affiliation":[{"name":"INSERM, Centre d\u2019Investigations Cliniques Plurith\u00e9matique 1433, Universit\u00e9 de Lorraine, CHRU de Nancy and F-CRIN INI-CRCT, Nancy, France"},{"name":"Cardiovascular Research and Development Unit, Department of Physiology and Cardiothoracic Surgery, University of Porto, Porto, Portugal"}]},{"given":"Patrick","family":"Rossignol","sequence":"additional","affiliation":[{"name":"INSERM, Centre d\u2019Investigations Cliniques Plurith\u00e9matique 1433, Universit\u00e9 de Lorraine, CHRU de Nancy and F-CRIN INI-CRCT, Nancy, France"}]},{"given":"Biniyam","family":"Demissei","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Groningen, University Medical Center Groningen, Hanzeplein, Groningen, The Netherlands"}]},{"given":"Abhinav","family":"Sharma","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA"},{"name":"Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada"}]},{"given":"Nicolas","family":"Girerd","sequence":"additional","affiliation":[{"name":"INSERM, Centre d\u2019Investigations Cliniques Plurith\u00e9matique 1433, Universit\u00e9 de Lorraine, CHRU de Nancy and F-CRIN INI-CRCT, Nancy, France"}]},{"given":"Stefan D","family":"Anker","sequence":"additional","affiliation":[{"name":"Department of Innovative Clinical Trials, University Medical Centre G\u00f6ttingen (UMG), Robert-Koch-Stra\u00dfe, G\u00f6ttingen, Germany"}]},{"given":"John G","family":"Cleland","sequence":"additional","affiliation":[{"name":"Robertson Centre for Biostatistics and Glasgow Clinical Trials Unit, Glasgow, UK"}]},{"given":"Kenneth","family":"Dickstein","sequence":"additional","affiliation":[{"name":"University of Bergen, Bergen, Norway"},{"name":"Stavanger University Hospital, Stavanger, Norway"}]},{"given":"Gerasimos","family":"Filippatos","sequence":"additional","affiliation":[{"name":"Heart Failure Unit, Department of Cardiology, National and Kapodistrian University of Athens, School of Medicine, Athens University Hospital Attikon, Rimini, Athens, Greece"}]},{"given":"Hans L","family":"Hillege","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Groningen, University Medical Center Groningen, Hanzeplein, Groningen, The Netherlands"}]},{"given":"Chim C","family":"Lang","sequence":"additional","affiliation":[{"name":"Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK"}]},{"given":"Marco","family":"Metra","sequence":"additional","affiliation":[{"name":"University of Brescia, Brescia, Italy"}]},{"given":"Leong L","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, United Kingdom and Cardiovascular Theme, NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK"}]},{"given":"Piotr","family":"Ponikowski","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Department of Heart Diseases, Centre for Heart Diseases, 4th Military Hospital, Wroclaw Medical University, Wroclaw, Poland"}]},{"given":"Nilesh 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