{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:18:41Z","timestamp":1771658321862,"version":"3.50.1"},"reference-count":28,"publisher":"BMJ","issue":"3","funder":[{"DOI":"10.13039\/501100003100","name":"F\u00e9d\u00e9ration Fran\u00e7aise de Cardiologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003100","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ligue Contre la Cardiomyopathie"},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[2019,7,1]]},"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>N-terminal probrain natriuretic peptide (NT-proBNP) predicts mortality and the development of heart failure in hypertrophic cardiomyopathy (HCM). Mid-regional proatrial natriuretic peptide (MR-proANP) is a stable by-product of production of atrial natriuretic peptide. We sought to compare the prognostic value of MR-proANP and NT-proBNP in HCM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We prospectively enrolled a cohort of patients with HCM from different European centres and followed them. All patients had clinical, ECG and echocardiographic evaluation and measurement of MR-proANP and NT-proBNP at inclusion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 357 patients enrolled, the median age was 52 (IQR: 36\u201365) years. MR-proANP and NT-proBNP were both independently associated with age, weight, New York Heart Association (NYHA) class, left ventricular ejection fraction (LVEF), wall thickness and left atrial dimension. During a median follow-up of 23 months, 32 patients had a primary end point defined as death (n=6), heart transplantation (n=8), left ventricular assist device implantation (n=1) or heart failure hospitalisation (n=17). Both NT-proBNP and MR-proANP (p&lt;10<jats:sup>\u20134<\/jats:sup>) were strongly associated with the primary endpoint, and the areas under the receiver operating characteristic (ROC) curves for both peptides were not significantly different. However, in a multiple stepwise regression analysis, the best model for predicting outcome was NYHA 1\u20132 vs 3\u20134 (HR=0.35, 95% CI 0.16 to 0.77, p&lt;0.01), LVEF (HR=0.96, 95% CI 0.94 to 0.98, p=0.0005) and MR-proANP (HR=3.77, 95% CI 2.01 to 7.08, p&lt;0.0001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>MR-proANP emerges as a valuable biomarker for the prediction of death and heart failure related events in patients with HCM.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heartjnl-2019-314826","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T17:15:27Z","timestamp":1564161327000},"page":"196-202","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Mid-regional proatrial natriuretic peptide for predicting prognosis in hypertrophic cardiomyopathy"],"prefix":"10.1136","volume":"106","author":[{"given":"C\u00e9line","family":"B\u00e9gu\u00e9","sequence":"first","affiliation":[{"name":"D\u00e9partement de Cardiologie, Hopital Piti\u00e9-Salp\u00eatri\u00e8re, APHP, Paris, France"}]},{"given":"Stellan","family":"M\u00f6rner","sequence":"additional","affiliation":[{"name":"Heart Centre and Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden"}]},{"given":"Dulce","family":"Brito","sequence":"additional","affiliation":[{"name":"Hospital de Santa Maria, Lisbon School of Medicine, Lisbon, Portugal"}]},{"given":"Christian","family":"Hengstenberg","sequence":"additional","affiliation":[{"name":"Cardiology, Medical University of Vienna, Vienna, Austria"}]},{"given":"John G F","family":"Cleland","sequence":"additional","affiliation":[{"name":"Robertson Institute of Biostatistics and Clinical Trials Unit, University of Glasgow, UK"},{"name":"Royal Brompton and Harefield Hospitals, Imperial College, London, UK"}]},{"given":"Eloisa","family":"Arbustini","sequence":"additional","affiliation":[{"name":"Centre for Inherited Cardiovascular Diseases, IRCCS Foundation, University Hospital Policlinico San Matteo, Pavia, Italy"}]},{"given":"Enrique","family":"Galve","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Hospital Universitario Valle Hebr\u00f3n, Barcelona, Spain"}]},{"given":"Thomas","family":"Wichter","sequence":"additional","affiliation":[{"name":"Niels-Stensen-Kliniken, Marienhospital, Heart Center Osnabr\u00fcck\u2013Bad Rothenfelde, Osnabr\u00fcck, Germany"}]},{"given":"Anette","family":"Richter","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin Kardiologie, Universit\u00e4tskilinikum Gie\u00dfen and Marburg, Marburg, Germany"}]},{"given":"Jean-Louis","family":"Golmard","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Information, Sorbonne University, AP-HP, Hopital Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}]},{"given":"Maguy","family":"Bernard","sequence":"additional","affiliation":[{"name":"Biochemistry, Hopital Piti\u00e9-Salp\u00eatri\u00e8re, AP\/HP, Paris, France"}]},{"given":"Olivier","family":"Dubourg","sequence":"additional","affiliation":[{"name":"Cardiology, Ambroise Par\u00e9 Hospital, Versailles-Saint Quentin University, Boulogne, France"}]},{"given":"Michel","family":"Komajda","sequence":"additional","affiliation":[{"name":"Cardiology, Hopital Saint Joseph, Paris, France"}]},{"given":"Philippe","family":"Charron","sequence":"additional","affiliation":[{"name":"Cardiology and Genetics, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, IHU-ICAN, UMR-S 1166, AP-HP, Sorbonne Universit\u00e9, Paris, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3439-8104","authenticated-orcid":false,"given":"Richard","family":"Isnard","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Cardiologie, Sorbonne Universit\u00e9, AP-HP, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Institute of Cardiometabolism and Nutrition (ICAN), ACTION Study Group, INSERM UMRS 1166, Paris 75013, France"}]}],"member":"239","published-online":{"date-parts":[[2019,7,26]]},"reference":[{"key":"2025092004540589000_106.3.196.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.01.023"},{"key":"2025092004540589000_106.3.196.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60397-3"},{"key":"2025092004540589000_106.3.196.3","first-page":"2733","article-title":"ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: The Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC)","volume":"2014","author":"Elliott","year":"2014","journal-title":"Eur Heart 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